Development Level

Tbio 1,604 | 11,651
Tdark 339 | 6,593
Tchem 247 | 1,388
Tclin 122 | 612

Collection

RFA-RM-18-021 35 | 328
GPCR: IDG Consortium (Targets) 17 | 126
Ion Channel: IDG Consortium (T... 10 | 99
GPCR: IDG Consortium (Complete... 7 | 25
Kinase: IDG Consortium (Comple... 7 | 37
Kinase: IDG Consortium (Target... 7 | 125

IMPC Phenotype

preweaning lethality, incomple... 80 | 499
preweaning lethality, complete... 72 | 979
enlarged heart 40 | 210
abnormal behavior 33 | 298
decreased vertical activity 33 | 208
abnormal embryo size 31 | 220
decreased total body fat amoun... 31 | 207
abnormal heart morphology 27 | 162
embryonic lethality prior to t... 26 | 278
cataract 24 | 92
abnormal seminal vesicle morph... 23 | 114
increased lean body mass 23 | 172
hypoactivity 22 | 132
abnormal bone structure 21 | 187
increased or absent threshold ... 21 | 101
abnormal lens morphology 20 | 81
decreased body weight 20 | 161
decreased lymphocyte cell numb... 20 | 83
abnormal skin morphology 17 | 50
decreased bone mineral content 17 | 151
embryonic lethality prior to o... 17 | 239
increased monocyte cell number 17 | 63
hyperactivity 16 | 148
increased bone mineral content 16 | 108
increased startle reflex 16 | 112
small superior vagus ganglion 16 | 74
abnormal kidney morphology 15 | 65
decreased mean corpuscular vol... 15 | 79
decreased prepulse inhibition 15 | 82
decreased startle reflex 15 | 75
decreased circulating serum al... 14 | 82
decreased grip strength 14 | 116
decreased leukocyte cell numbe... 14 | 73
increased total body fat amoun... 14 | 134
abnormal sleep behavior 13 | 70
impaired glucose tolerance 13 | 75
increased fasted circulating g... 13 | 76
decreased circulating glucose ... 12 | 126
decreased circulating insulin ... 12 | 76
hydrometra 12 | 53
increased mean corpuscular hem... 12 | 96
short tibia 12 | 97
decreased bone mineral density 11 | 126
decreased hemoglobin content 11 | 68
decreased lean body mass 11 | 135
increased circulating triglyce... 11 | 42
increased neutrophil cell numb... 11 | 46
abnormal coat-hair pigmentatio... 10 | 64
abnormal eye morphology 10 | 68
abnormal retina morphology 10 | 71
decreased body length 10 | 101
decreased circulating choleste... 10 | 93
decreased circulating triglyce... 10 | 79
decreased fasted circulating g... 10 | 65
improved glucose tolerance 10 | 79
increased circulating alkaline... 10 | 122
increased mean corpuscular vol... 10 | 92
male infertility 10 | 123
thrombocytopenia 10 | 56
abnormal epididymis morphology 9 | 42
abnormal gait 9 | 69
abnormal spleen morphology 9 | 55
decreased blood urea nitrogen ... 9 | 51
decreased erythrocyte cell num... 9 | 62
decreased mean corpuscular hem... 9 | 50
increased blood urea nitrogen ... 9 | 48
increased circulating HDL chol... 9 | 80
increased erythrocyte cell num... 9 | 39
increased heart weight 9 | 62
limb grasping 9 | 41
small testis 9 | 58
abnormal behavioral response t... 8 | 66
abnormal testis morphology 8 | 43
decreased circulating total pr... 8 | 49
decreased hematocrit 8 | 46
embryonic growth retardation 8 | 106
impaired righting response 8 | 26
increased bone mineral density 8 | 72
prenatal lethality prior to he... 8 | 87
abnormal coat appearance 7 | 31
decreased circulating HDL chol... 7 | 68
decreased circulating alkaline... 7 | 46
decreased threshold for audito... 7 | 26
increased body weight 7 | 25
increased circulating choleste... 7 | 66
increased vertical activity 7 | 24
absent startle reflex 6 | 24
decreased circulating bilirubi... 6 | 19
decreased circulating potassiu... 6 | 20
decreased red blood cell distr... 6 | 41
enlarged lymph nodes 6 | 37
female infertility 6 | 60
increased body length 6 | 32
increased circulating calcium ... 6 | 34
increased circulating potassiu... 6 | 29
increased circulating sodium l... 6 | 71
increased mean platelet volume 6 | 45
corneal opacity 5 | 32
decreased circulating aspartat... 5 | 34
increased prepulse inhibition 5 | 32

Disease

interstitial cystitis 2,312 | 2,312
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 2,268 | 17,369
Endocrine System 2,262 | 18,159
Female tissues 2,262 | 17,400
Urinary Tract 2,262 | 16,678
Male tissues 2,260 | 17,142
Skin and soft tissues 2,258 | 17,230
Blood and immune system 2,242 | 16,909
Liver and Pancreas 2,240 | 16,750
Respiratory system 2,234 | 16,393
Nervous System 2,197 | 16,725
Cardiovascular System 2,103 | 15,192

Target Family

Non-IDG 1,371 | 12,091
Enzyme 494 | 4,145
Transcription Factor 155 | 1,400
Kinase 88 | 634
GPCR 75 | 408
Transporter 59 | 473
Ion Channel 42 | 344
Nuclear Receptor 13 | 48
Epigenetic 9 | 242
TF/Epigenetic 4 | 38
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
IQ and AAA domain-containing protein 1 IQCA1 Tbio Non-IDG -0.80618 5.26 77
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667