Development Level

Tbio 1,444 | 10,625
Tdark 393 | 7,003
Tchem 343 | 1,890
Tclin 119 | 602

Collection

Eligible non-olfactory GPCR Proteins 17 | 143
Eligible Ion Channel Proteins 11 | 117
Eligible Kinase Proteins 7 | 134

IMPC Term

preweaning lethality, complete... 56 | 633
preweaning lethality, incomple... 46 | 260
decreased lean body mass 28 | 195
abnormal behavior 26 | 226
decreased total body fat amoun... 25 | 186
enlarged heart 24 | 111
decreased body weight 22 | 174
increased or absent threshold ... 21 | 128
abnormal bone structure 18 | 131
decreased bone mineral content 18 | 157
embryonic lethality prior to t... 17 | 187
abnormal lens morphology 16 | 73
decreased body length 16 | 108
decreased circulating insulin ... 15 | 75
hypoactivity 15 | 89
decreased bone mineral density 14 | 126
decreased circulating serum al... 14 | 79
decreased grip strength 14 | 123
increased lean body mass 14 | 107
abnormal embryo size 13 | 112
abnormal retina morphology 13 | 100
abnormal seminal vesicle morph... 13 | 47
decreased circulating glucose ... 13 | 121
increased bone mineral content 13 | 92
decreased circulating triglyce... 12 | 83
decreased prepulse inhibition 12 | 52
increased circulating alkaline... 12 | 119
decreased circulating HDL chol... 11 | 77
decreased circulating choleste... 11 | 85
decreased mean corpuscular vol... 11 | 50
hyperactivity 11 | 108
increased grip strength 11 | 83
increased mean corpuscular hem... 11 | 93
increased mean corpuscular vol... 11 | 91
abnormal heart morphology 10 | 51
abnormal sleep behavior 10 | 63
embryonic lethality prior to o... 10 | 148
increased blood urea nitrogen ... 10 | 44
increased fasted circulating g... 10 | 68
small testis 10 | 37
abnormal coat/hair pigmentatio... 9 | 54
decreased hemoglobin content 9 | 53
impaired glucose tolerance 9 | 52
increased circulating sodium l... 9 | 71
increased sacral vertebrae num... 9 | 62
male infertility 9 | 62
short tibia 9 | 82
abnormal bone mineralization 8 | 55
abnormal skin morphology 8 | 23
abnormal testis morphology 8 | 30
cataract 8 | 26
decreased caudal vertebrae num... 8 | 49
decreased circulating alkaline... 8 | 41
decreased fasted circulating g... 8 | 49
decreased leukocyte cell numbe... 8 | 54
decreased lumbar vertebrae num... 8 | 62
increased body weight 8 | 42
thrombocytopenia 8 | 46
abnormal behavioral response t... 7 | 52
abnormal epididymis morphology 7 | 31
abnormal spleen morphology 7 | 36
decreased mean corpuscular hem... 7 | 34
decreased rib number 7 | 59
decreased startle reflex 7 | 48
improved glucose tolerance 7 | 56
increased bone mineral density 7 | 52
increased circulating HDL chol... 7 | 63
increased circulating calcium ... 7 | 32
increased circulating potassiu... 7 | 31
increased exploration in new e... 7 | 56
small superior vagus ganglion 7 | 20
abnormal kidney morphology 6 | 30
abnormal retinal pigmentation 6 | 61
cardiovascular system phenotyp... 6 | 35
decreased blood urea nitrogen ... 6 | 31
decreased circulating potassiu... 6 | 17
decreased threshold for audito... 6 | 32
female infertility 6 | 34
increased circulating triglyce... 6 | 24
increased heart weight 6 | 37
increased hemoglobin content 6 | 45
increased vertical activity 6 | 18
limb grasping 6 | 35
abnormal coat appearance 5 | 25
abnormal locomotor activation 5 | 26
corneal opacity 5 | 25
decreased NK T cell number 5 | 28
decreased circulating free fat... 5 | 39
decreased circulating fructosa... 5 | 31
decreased circulating glycerol... 5 | 19
decreased circulating total pr... 5 | 41
decreased eosinophil cell numb... 5 | 41
decreased heart weight 5 | 44
decreased hematocrit 5 | 25
enlarged epididymis 5 | 27
enlarged spleen 5 | 26
increased circulating choleste... 5 | 53
increased circulating serum al... 5 | 25
increased hematocrit 5 | 36
increased total body fat amoun... 5 | 57

Disease

interstitial cystitis 2,299 | 2,299
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Liver and Pancreas 2,277 | 18,136
Digestive Tract 2,276 | 18,473
Female tissues 2,276 | 18,647
Nervous System 2,275 | 18,561
Endocrine System 2,273 | 18,512
Male tissues 2,273 | 17,969
Urinary Tract 2,273 | 18,444
Cardiovascular System 2,269 | 17,958
Blood and immune system 2,266 | 17,995
Respiratory system 2,260 | 17,484
Skin and soft tissues 2,259 | 18,115

Target Family

Non-IDG 1,362 | 11,971
Enzyme 493 | 4,146
Transcription Factor 155 | 1,400
Kinase 87 | 634
GPCR 75 | 406
Transporter 59 | 473
Ion Channel 41 | 341
Nuclear Receptor 13 | 48
Epigenetic 8 | 242
TF/Epigenetic 4 | 38
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788