1. Home
  2. Targets
Target Filters...

Development Level

Tbio 192 | 11,445
Tdark 53 | 6,588
Tchem 29 | 1,598
Tclin 12 | 613

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 8 | 499
abnormal behavior 5 | 298
increased circulating HDL chol... 5 | 80
abnormal embryo size 4 | 220
abnormal seminal vesicle morph... 4 | 114
decreased circulating serum al... 4 | 82
decreased mean corpuscular vol... 4 | 79
decreased vertical activity 4 | 208
enlarged heart 4 | 210
increased circulating choleste... 4 | 66
abnormal coat-hair pigmentatio... 3 | 64
abnormal heart morphology 3 | 162
abnormal kidney morphology 3 | 65
decreased body weight 3 | 161
decreased circulating creatini... 3 | 39
decreased total body fat amoun... 3 | 207
increased fasted circulating g... 3 | 76
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
abnormal lens morphology 2 | 81
anophthalmia 2 | 33
cataract 2 | 92
decreased circulating choleste... 2 | 93
decreased circulating free fat... 2 | 31
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased fasted circulating g... 2 | 65
decreased lymphocyte cell numb... 2 | 83
decreased neutrophil cell numb... 2 | 42
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
female infertility 2 | 60
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating creatini... 2 | 38
increased circulating triglyce... 2 | 42
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 36
syndactyly 2 | 23
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal pancreas morphology 1 | 13
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal vitreous body morphol... 1 | 10
abnormal whole-body plethysmog... 1 | 4
absent lymph nodes 1 | 3
brachydactyly 1 | 19
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating phosphat... 1 | 27
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
shortened RR interval 1 | 17
small testis 1 | 58
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

inflammatory breast cancer 286 | 286
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 277 | 18,159
Female tissues 277 | 17,400
Skin and soft tissues 277 | 17,230
Digestive Tract 275 | 17,369
Male tissues 271 | 17,142
Urinary Tract 271 | 16,678
Blood and immune system 270 | 16,909
Liver and Pancreas 270 | 16,750
Respiratory system 267 | 16,393
Nervous System 263 | 16,725
Cardiovascular System 248 | 15,192

Target Family

Non-IDG 177 | 12,091
Enzyme 67 | 4,145
Transcription Factor 15 | 1,400
Kinase 8 | 634
GPCR 6 | 408
Transporter 6 | 473
Epigenetic 3 | 242
Ion Channel 3 | 344
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Androgen-induced gene 1 protein AIG1 Tbio Non-IDG -0.92777 6.52 111
Integrin alpha-7 ITGA7 Tbio Non-IDG -1.63563 42.4 193
Sorting nexin-10 SNX10 Tbio Non-IDG -1.13183 16.8 72
1-aminocyclopropane-1-carboxylate synthase-like protein 1 ACCS Tbio Enzyme -2.31602 195.2 154
Melanocyte-stimulating hormone receptor MC1R Tclin GPCR -2.90014 829.2 194
Transient receptor potential cation channel subfamily V member 2 TRPV2 Tchem Ion Channel -2.28525 197.9 203
Torsin-4A TOR4A Tdark Non-IDG 0.77 0.09 17
Cholesterol 25-hydroxylase CH25H Tbio Enzyme -1.54426 38.2 54