Development Level

Tbio 233 | 10,625
Tdark 39 | 7,003
Tchem 37 | 1,890
Tclin 4 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 21 | 633
embryonic lethality prior to t... 8 | 187
decreased total body fat amoun... 7 | 186
preweaning lethality, incomple... 7 | 260
decreased lean body mass 6 | 195
embryonic lethality prior to o... 6 | 148
increased or absent threshold ... 6 | 128
abnormal retina morphology 5 | 100
decreased bone mineral content 5 | 157
decreased circulating glucose ... 5 | 121
increased lean body mass 5 | 107
abnormal bone structure 4 | 131
decreased circulating HDL chol... 4 | 77
decreased circulating insulin ... 4 | 75
increased bone mineral content 4 | 92
increased mean corpuscular hem... 4 | 93
abnormal behavior 3 | 226
abnormal embryo size 3 | 112
abnormal femur morphology 3 | 14
abnormal sleep behavior 3 | 63
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
decreased circulating choleste... 3 | 85
decreased circulating triglyce... 3 | 83
decreased hemoglobin content 3 | 53
decreased startle reflex 3 | 48
increased circulating alkaline... 3 | 119
increased circulating sodium l... 3 | 71
increased mean corpuscular hem... 3 | 25
limb grasping 3 | 35
shortened RR interval 3 | 19
tremors 3 | 34
abnormal coat/ hair morphology 2 | 18
abnormal coat/hair pigmentatio... 2 | 54
abnormal embryo turning 2 | 15
abnormal gait 2 | 51
abnormal lens morphology 2 | 73
abnormal spleen morphology 2 | 36
abnormal tail morphology 2 | 17
decreased CD4-positive, CD25-p... 2 | 24
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased cervical vertebrae n... 2 | 12
decreased circulating alanine ... 2 | 53
decreased circulating glycerol... 2 | 19
decreased circulating serum al... 2 | 79
decreased erythrocyte cell num... 2 | 43
decreased grip strength 2 | 123
decreased heart rate 2 | 10
decreased heart weight 2 | 44
decreased leukocyte cell numbe... 2 | 54
decreased mean corpuscular vol... 2 | 50
decreased respiratory quotient 2 | 12
decreased vertical activity 2 | 22
enlarged lymph nodes 2 | 27
female infertility 2 | 34
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
increased bone mineral density 2 | 52
increased circulating chloride... 2 | 43
increased exploration in new e... 2 | 56
increased heart rate 2 | 17
increased hemoglobin content 2 | 45
increased kidney weight 2 | 4
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
increased startle reflex 2 | 38
shortened ST segment 2 | 9
thrombocytopenia 2 | 46
thrombocytosis 2 | 23
abnormal behavioral response t... 1 | 52
abnormal cranium morphology 1 | 32
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal retinal inner nuclear... 1 | 5
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 21
convulsive seizures 1 | 11
decreased circulating magnesiu... 1 | 11
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased mean corpuscular hem... 1 | 34
decreased pulmonary respirator... 1 | 4
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
vertebral fusion 1 | 23

Disease

hereditary spastic paraplegia 313 | 313
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 313 | 17,995
Cardiovascular System 313 | 17,958
Digestive Tract 313 | 18,473
Endocrine System 313 | 18,512
Female tissues 313 | 18,647
Liver and Pancreas 313 | 18,136
Male tissues 313 | 17,969
Nervous System 313 | 18,561
Respiratory system 313 | 17,484
Skin and soft tissues 313 | 18,115
Urinary Tract 313 | 18,444

Target Family

Non-IDG 185 | 11,971
Enzyme 95 | 4,146
Transcription Factor 10 | 1,400
Kinase 7 | 634
Transporter 7 | 473
Ion Channel 4 | 341
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38
Epigenetic 1 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Beta-1,4 N-acetylgalactosaminyltransferase 1 B4GALNT1 Tbio Enzyme -1.85387 67.6 146
Transmembrane 6 superfamily member 1 TM6SF1 Tdark Non-IDG -0.16400 2.15 54
Serine/arginine repetitive matrix protein 2 SRRM2 Tbio Non-IDG -1.90106 71.6 51
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.04569 136.6 321
Acylphosphatase-2 ACYP2 Tbio Enzyme -1.25910 20.1 46
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A ANKRD28 Tbio Enzyme -0.56847 4.64 67
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169