Development Level

Tbio 330 | 10,625
Tdark 109 | 7,003
Tchem 74 | 1,890
Tclin 19 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 25 | 633
embryonic lethality prior to t... 12 | 187
embryonic lethality prior to o... 8 | 148
preweaning lethality, incomple... 8 | 260
decreased lean body mass 6 | 195
abnormal embryo size 5 | 112
decreased CD8-positive, alpha-... 5 | 26
enlarged heart 5 | 111
abnormal behavior 4 | 226
abnormal bone structure 4 | 131
abnormal heart morphology 4 | 51
abnormal retina morphology 4 | 100
decreased NK T cell number 4 | 28
decreased body weight 4 | 174
decreased bone mineral content 4 | 157
decreased circulating glucose ... 4 | 121
decreased hemoglobin content 4 | 53
decreased leukocyte cell numbe... 4 | 54
decreased prepulse inhibition 4 | 52
decreased total body fat amoun... 4 | 186
improved glucose tolerance 4 | 56
increased bone mineral content 4 | 92
increased circulating calcium ... 4 | 32
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
thrombocytopenia 4 | 46
abnormal lens morphology 3 | 73
abnormal sleep behavior 3 | 63
decreased CD4-positive, CD25-p... 3 | 24
decreased T cell number 3 | 31
decreased alpha-beta T cell nu... 3 | 12
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased heart weight 3 | 44
decreased mean corpuscular hem... 3 | 34
increased body length 3 | 20
increased circulating HDL chol... 3 | 63
increased circulating alkaline... 3 | 119
increased grip strength 3 | 83
increased heart weight 3 | 37
increased lean body mass 3 | 107
increased startle reflex 3 | 38
abnormal coat/hair pigmentatio... 2 | 54
abnormal eye morphology 2 | 38
abnormal lung morphology 2 | 15
abnormal neural tube closure 2 | 37
abnormal neural tube morpholog... 2 | 8
abnormal retinal blood vessel ... 2 | 18
abnormal retinal vasculature m... 2 | 15
abnormal skin morphology 2 | 23
abnormal spleen morphology 2 | 36
cataract 2 | 26
decreased body length 2 | 108
decreased circulating alanine ... 2 | 53
decreased circulating amylase ... 2 | 24
decreased circulating total pr... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
female infertility 2 | 34
hydrops fetalis 2 | 22
impaired glucose tolerance 2 | 52
increased blood urea nitrogen ... 2 | 44
increased body weight 2 | 42
increased circulating aspartat... 2 | 17
increased circulating choleste... 2 | 53
increased circulating glucose ... 2 | 16
increased circulating total pr... 2 | 20
increased effector memory T-he... 2 | 5
increased fasted circulating g... 2 | 68
increased monocyte cell number 2 | 27
increased prepulse inhibition 2 | 21
increased sacral vertebrae num... 2 | 62
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
abnormal coping response 1 | 12
abnormal embryo turning 1 | 15
abnormal locomotor activation 1 | 26
abnormal retinal pigmentation 1 | 61
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased blood urea nitrogen ... 1 | 31
decreased circulating chloride... 1 | 32
decreased effector memory CD8-... 1 | 24
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
embryonic growth retardation 1 | 28
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased CD5-positive Ly6C-po... 1 | 4
increased NK cell number 1 | 19
increased circulating alanine ... 1 | 11
increased circulating creatini... 1 | 29
increased circulating triglyce... 1 | 24
increased lactate dehydrogenas... 1 | 3
increased rib number 1 | 41
limb grasping 1 | 35

Disease

hepatocellular carcinoma 532 | 532
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 527 | 17,995
Digestive Tract 527 | 18,473
Endocrine System 527 | 18,512
Liver and Pancreas 527 | 18,136
Cardiovascular System 526 | 17,958
Female tissues 526 | 18,647
Nervous System 526 | 18,561
Skin and soft tissues 525 | 18,115
Urinary Tract 525 | 18,444
Male tissues 524 | 17,969
Respiratory system 523 | 17,484

Target Family

Non-IDG 301 | 11,971
Enzyme 135 | 4,146
Transcription Factor 46 | 1,400
GPCR 14 | 406
Kinase 12 | 634
Transporter 10 | 473
Epigenetic 6 | 242
Ion Channel 4 | 341
Nuclear Receptor 2 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
NHL repeat-containing protein 2 NHLRC2 Tdark Non-IDG 0.78 1.17 50
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
ER degradation-enhancing alpha-mannosidase-like protein 3 EDEM3 Tbio Enzyme -0.45279 2.45 72
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.65303 525.6 142
Ferritin heavy chain FTH1 Tbio Non-IDG -2.95630 924.5 435
Protein artemis DCLRE1C Tbio Non-IDG -1.63807 45.4 225
Toll-like receptor 7 TLR7 Tclin Non-IDG -2.92878 974.2 670