Development Level

Tbio 141 | 10,625
Tchem 57 | 1,890
Tdark 25 | 7,003
Tclin 14 | 602

Collection

Eligible non-olfactory GPCR Proteins 2 | 145
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 5 | 633
decreased circulating glucose ... 4 | 121
decreased circulating insulin ... 4 | 75
decreased grip strength 4 | 123
decreased lean body mass 4 | 195
increased circulating sodium l... 4 | 71
abnormal behavior 3 | 226
abnormal coping response 3 | 12
abnormal lens morphology 3 | 73
abnormal sleep behavior 3 | 63
decreased bone mineral content 3 | 157
enlarged heart 3 | 111
increased circulating alkaline... 3 | 119
increased mean corpuscular hem... 3 | 93
increased mean corpuscular hem... 3 | 25
abnormal heart morphology 2 | 51
cataract 2 | 26
decreased circulating glycerol... 2 | 19
decreased heart weight 2 | 44
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased total body fat amoun... 2 | 186
embryonic lethality prior to t... 2 | 187
hyperactivity 2 | 108
increased bone mineral content 2 | 92
increased erythrocyte cell num... 2 | 26
increased hemoglobin content 2 | 45
preweaning lethality, incomple... 2 | 260
short tibia 2 | 82
thrombocytopenia 2 | 46
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal optic disc morphology 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal skin morphology 1 | 23
abnormal tail morphology 1 | 17
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 7
cardiovascular system phenotyp... 1 | 35
cleft palate 1 | 6
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating bilirubi... 1 | 14
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased follicular B cell nu... 1 | 4
decreased heart rate variabili... 1 | 11
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mean platelet volume 1 | 12
decreased prepulse inhibition 1 | 52
dilated heart left ventricle 1 | 10
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
herniated abdominal wall 1 | 4
improved glucose tolerance 1 | 56
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating potassiu... 1 | 31
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased prepulse inhibition 1 | 21
increased red blood cell distr... 1 | 21
increased respiratory quotient 1 | 12
increased spleen weight 1 | 3
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
premature death 1 | 5
shortened PQ interval 1 | 6
straub tail 1 | 26
tremors 1 | 34

Disease

head and neck cancer and chronic obstructive pulmonary disease 237 | 237
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 234 | 18,473
Nervous System 234 | 18,561
Endocrine System 233 | 18,512
Female tissues 233 | 18,647
Male tissues 233 | 17,969
Respiratory system 233 | 17,484
Liver and Pancreas 232 | 18,136
Urinary Tract 232 | 18,444
Blood and immune system 231 | 17,995
Cardiovascular System 231 | 17,958
Skin and soft tissues 231 | 18,115

Target Family

Non-IDG 134 | 11,969
Enzyme 66 | 4,146
GPCR 12 | 408
Transcription Factor 9 | 1,400
Transporter 6 | 473
Kinase 5 | 634
Ion Channel 3 | 341
Epigenetic 1 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lebercilin LCA5 Tbio Non-IDG -1.21162 16.7 65
GTPase IMAP family member 4 GIMAP4 Tbio Enzyme -0.97980 10.2 121
Scavenger receptor cysteine-rich type 1 protein M130 CD163 Tbio Non-IDG -2.86758 701.8 663
Guanine deaminase GDA Tbio Enzyme -1.44695 29.5 157
Interleukin-21 receptor IL21R Tbio Non-IDG -1.89974 76.0 285
Leucine zipper protein 1 LUZP1 Tdark Non-IDG -0.56441 4.08 75
Regulating synaptic membrane exocytosis protein 1 RIMS1 Tbio Non-IDG -1.94710 81.5 12
SLAM family member 5 CD84 Tbio Non-IDG -1.41596 28.1 393
Carboxypeptidase M CPM Tchem Enzyme -2.12717 127.7 168
Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 Tchem Enzyme -1.84829 67.3 189