1. Home
  2. Targets
Target Filters...

Development Level

Tbio 1,208 | 11,445
Tdark 408 | 6,588
Tchem 182 | 1,598
Tclin 57 | 613

Collection

RFA-RM-18-021 36 | 328
Kinase: IDG Consortium (Target... 23 | 125
Kinase: IDG Consortium (Comple... 10 | 37
GPCR: IDG Consortium (Targets) 7 | 126
Ion Channel: IDG Consortium (T... 6 | 99
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 98 | 979
preweaning lethality, incomple... 68 | 499
decreased total body fat amoun... 34 | 207
embryonic lethality prior to t... 33 | 278
abnormal behavior 31 | 298
abnormal embryo size 26 | 220
abnormal heart morphology 26 | 162
increased lean body mass 24 | 172
abnormal bone structure 23 | 187
enlarged heart 23 | 210
decreased bone mineral content 22 | 151
decreased lean body mass 22 | 135
embryonic lethality prior to o... 20 | 239
increased bone mineral content 20 | 108
decreased body length 18 | 101
increased or absent threshold ... 18 | 101
increased total body fat amoun... 18 | 134
decreased lymphocyte cell numb... 17 | 83
decreased vertical activity 16 | 208
hyperactivity 16 | 148
increased circulating choleste... 16 | 66
decreased bone mineral density 15 | 126
embryonic growth retardation 15 | 106
increased circulating HDL chol... 15 | 80
increased startle reflex 15 | 112
abnormal gait 14 | 69
decreased body weight 14 | 161
decreased grip strength 14 | 116
increased bone mineral density 14 | 72
hypoactivity 13 | 132
increased circulating alkaline... 13 | 122
short tibia 13 | 97
abnormal seminal vesicle morph... 11 | 114
cataract 11 | 92
decreased circulating choleste... 11 | 93
decreased circulating glucose ... 11 | 126
decreased prepulse inhibition 11 | 82
increased monocyte cell number 11 | 63
male infertility 11 | 123
small superior vagus ganglion 11 | 74
abnormal coat-hair pigmentatio... 10 | 64
abnormal lens morphology 10 | 81
decreased circulating serum al... 10 | 82
decreased fasted circulating g... 10 | 65
decreased leukocyte cell numbe... 10 | 73
increased mean corpuscular vol... 10 | 92
increased neutrophil cell numb... 10 | 46
abnormal cranium morphology 9 | 36
abnormal sleep behavior 9 | 70
decreased circulating HDL chol... 9 | 68
decreased erythrocyte cell num... 9 | 62
decreased mean corpuscular vol... 9 | 79
decreased startle reflex 9 | 75
impaired glucose tolerance 9 | 75
small testis 9 | 58
abnormal eye morphology 8 | 68
abnormal retina morphology 8 | 71
abnormal skin morphology 8 | 50
abnormal testis morphology 8 | 43
decreased circulating triglyce... 8 | 79
edema 8 | 59
hydrometra 8 | 53
improved glucose tolerance 8 | 79
increased blood urea nitrogen ... 8 | 48
increased circulating sodium l... 8 | 71
increased lymphocyte cell numb... 8 | 32
increased mean corpuscular hem... 8 | 96
abnormal retinal blood vessel ... 7 | 26
abnormal snout morphology 7 | 23
decreased blood urea nitrogen ... 7 | 51
decreased circulating alkaline... 7 | 46
decreased circulating creatini... 7 | 39
decreased hematocrit 7 | 46
decreased mean corpuscular hem... 7 | 50
decreased neutrophil cell numb... 7 | 42
enlarged spleen 7 | 41
female infertility 7 | 60
increased circulating triglyce... 7 | 42
increased mean corpuscular hem... 7 | 36
increased mean platelet volume 7 | 45
increased red blood cell distr... 7 | 34
abnormal tooth morphology 6 | 24
decreased circulating calcium ... 6 | 36
decreased circulating total pr... 6 | 49
decreased mean corpuscular hem... 6 | 31
decreased red blood cell distr... 6 | 41
enlarged lymph nodes 6 | 37
impaired pupillary reflex 6 | 26
increased circulating phosphat... 6 | 26
increased fasted circulating g... 6 | 76
increased heart weight 6 | 62
increased hematocrit 6 | 46
limb grasping 6 | 41
thrombocytopenia 6 | 56
abnormal bone mineralization 5 | 38
abnormal kidney morphology 5 | 65
abnormal locomotor behavior 5 | 24
decreased circulating LDL chol... 5 | 38
decreased circulating free fat... 5 | 31
prenatal lethality prior to he... 5 | 87

Disease

group 4 medulloblastoma 1,855 | 1,855
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 1,832 | 18,159
Nervous System 1,826 | 16,725
Female tissues 1,815 | 17,400
Digestive Tract 1,811 | 17,369
Skin and soft tissues 1,809 | 17,230
Male tissues 1,808 | 17,142
Liver and Pancreas 1,795 | 16,750
Urinary Tract 1,791 | 16,678
Blood and immune system 1,788 | 16,909
Respiratory system 1,777 | 16,393
Cardiovascular System 1,718 | 15,192

Target Family

Non-IDG 1,025 | 12,091
Enzyme 432 | 4,145
Transcription Factor 183 | 1,400
Kinase 88 | 634
Transporter 40 | 473
Ion Channel 28 | 344
GPCR 26 | 408
Epigenetic 21 | 242
Nuclear Receptor 9 | 48
TF/Epigenetic 2 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Zinc finger protein 160 ZNF160 Tdark Transcription Factor -0.67261 4.33 63
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 Tclin Enzyme -1.42734 26.2 214
Cadherin-18 CDH18 Tdark Non-IDG -0.64897 4.11 125
LIM domain only protein 7 LMO7 Tbio Non-IDG -1.24771 19.7 80
Protocadherin beta-14 PCDHB14 Tdark Non-IDG 0.78 0.14 90
Glutamate-rich protein 1 ERICH1 Tdark Non-IDG 0.35 0.38 18
Protocadherin beta-13 PCDHB13 Tdark Non-IDG 0.00000 101