Development Level

Tbio 1,218 | 10,625
Tdark 391 | 7,003
Tchem 202 | 1,890
Tclin 64 | 602

Collection

Eligible Kinase Proteins 20 | 134
Eligible Ion Channel Proteins 11 | 117
Eligible non-olfactory GPCR Proteins 6 | 143

IMPC Term

preweaning lethality, complete... 69 | 633
preweaning lethality, incomple... 45 | 260
decreased total body fat amoun... 34 | 186
abnormal behavior 31 | 226
decreased lean body mass 27 | 195
decreased bone mineral content 21 | 157
decreased body weight 20 | 174
abnormal bone structure 19 | 131
decreased bone mineral density 17 | 126
decreased grip strength 17 | 123
decreased body length 16 | 108
embryonic lethality prior to t... 16 | 187
hyperactivity 16 | 108
increased lean body mass 16 | 107
increased or absent threshold ... 16 | 128
increased bone mineral content 15 | 92
abnormal embryo size 13 | 112
abnormal retina morphology 13 | 100
decreased circulating HDL chol... 13 | 77
decreased circulating choleste... 12 | 85
increased circulating alkaline... 12 | 119
abnormal gait 11 | 51
abnormal lens morphology 11 | 73
increased circulating sodium l... 11 | 71
increased mean corpuscular vol... 11 | 91
decreased circulating glucose ... 10 | 121
decreased rib number 10 | 59
increased bone mineral density 10 | 52
increased total body fat amoun... 10 | 57
short tibia 10 | 82
abnormal sleep behavior 9 | 63
enlarged heart 9 | 111
hypoactivity 9 | 89
impaired glucose tolerance 9 | 52
increased blood urea nitrogen ... 9 | 44
increased circulating choleste... 9 | 53
increased mean corpuscular hem... 9 | 93
abnormal heart morphology 8 | 51
abnormal retinal blood vessel ... 8 | 18
abnormal retinal pigmentation 8 | 61
decreased blood urea nitrogen ... 8 | 31
decreased circulating serum al... 8 | 79
decreased circulating triglyce... 8 | 83
decreased erythrocyte cell num... 8 | 43
increased circulating HDL chol... 8 | 63
male infertility 8 | 62
prenatal lethality prior to he... 8 | 64
small testis 8 | 37
abnormal bone mineralization 7 | 55
abnormal seminal vesicle morph... 7 | 47
abnormal testis morphology 7 | 30
abnormal tooth morphology 7 | 24
decreased fasted circulating g... 7 | 49
decreased hemoglobin content 7 | 53
decreased mean corpuscular vol... 7 | 50
increased circulating calcium ... 7 | 32
abnormal coat appearance 6 | 25
abnormal coat/hair pigmentatio... 6 | 54
abnormal retinal vasculature m... 6 | 15
decreased circulating LDL chol... 6 | 37
decreased circulating creatini... 6 | 31
decreased hematocrit 6 | 25
decreased leukocyte cell numbe... 6 | 54
decreased mean corpuscular hem... 6 | 19
decreased monocyte cell number 6 | 28
decreased startle reflex 6 | 48
enlarged lymph nodes 6 | 27
immune system phenotype 6 | 17
increased body weight 6 | 42
increased circulating triglyce... 6 | 24
increased exploration in new e... 6 | 56
increased grip strength 6 | 83
increased hematocrit 6 | 36
increased hemoglobin content 6 | 45
increased red blood cell distr... 6 | 21
thrombocytopenia 6 | 46
abnormal cornea morphology 5 | 24
abnormal cranium morphology 5 | 32
abnormal neural tube closure 5 | 37
abnormal skin morphology 5 | 23
corneal opacity 5 | 25
decreased circulating free fat... 5 | 39
decreased eosinophil cell numb... 5 | 41
decreased lumbar vertebrae num... 5 | 62
decreased mean corpuscular hem... 5 | 34
embryonic lethality prior to o... 5 | 148
improved glucose tolerance 5 | 56
increased circulating chloride... 5 | 43
increased circulating phosphat... 5 | 24
increased fasted circulating g... 5 | 68
increased mean platelet volume 5 | 19
increased neutrophil cell numb... 5 | 15
increased rib number 5 | 41
limb grasping 5 | 35
straub tail 5 | 26
abnormal epididymis morphology 4 | 31
decreased circulating fructosa... 4 | 31
decreased circulating insulin ... 4 | 75
decreased prepulse inhibition 4 | 52
increased prepulse inhibition 4 | 21

Disease

group 4 medulloblastoma 1,875 | 1,875
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 1,859 | 18,647
Digestive Tract 1,858 | 18,473
Nervous System 1,856 | 18,561
Blood and immune system 1,853 | 17,995
Liver and Pancreas 1,853 | 18,136
Urinary Tract 1,853 | 18,444
Male tissues 1,852 | 17,969
Endocrine System 1,851 | 18,512
Cardiovascular System 1,849 | 17,958
Skin and soft tissues 1,836 | 18,115
Respiratory system 1,832 | 17,484

Target Family

Non-IDG 1,006 | 11,971
Enzyme 418 | 4,146
Transcription Factor 228 | 1,400
Kinase 77 | 634
Transporter 47 | 473
Ion Channel 33 | 341
GPCR 26 | 406
Epigenetic 23 | 242
Nuclear Receptor 13 | 48
TF/Epigenetic 3 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Protein THEMIS2 THEMIS2 Tbio Non-IDG -1.15987 17.5 42
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
Kinesin-like protein KIF1C KIF1C Tbio Non-IDG -1.21884 20.0 95
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307