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Development Level

Tbio 1,148 | 11,178
Tdark 404 | 6,569
Tchem 197 | 1,885
Tclin 57 | 612

Collection

Kinase: IDG Consortium (Target... 22 | 125
Kinase: IDG Consortium (Comple... 10 | 37
GPCR: IDG Consortium (Targets) 7 | 126
Ion Channel: IDG Consortium (T... 6 | 99
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 98 | 979
preweaning lethality, incomple... 65 | 499
decreased total body fat amoun... 34 | 207
embryonic lethality prior to t... 33 | 278
abnormal behavior 30 | 298
abnormal embryo size 26 | 220
abnormal heart morphology 25 | 162
increased lean body mass 24 | 172
abnormal bone structure 23 | 187
enlarged heart 21 | 210
decreased bone mineral content 20 | 151
decreased lean body mass 20 | 135
embryonic lethality prior to o... 20 | 239
increased bone mineral content 20 | 108
increased or absent threshold ... 18 | 101
decreased body length 17 | 101
increased total body fat amoun... 17 | 134
decreased lymphocyte cell numb... 16 | 83
decreased vertical activity 16 | 208
hyperactivity 16 | 148
decreased bone mineral density 15 | 126
embryonic growth retardation 15 | 106
increased startle reflex 15 | 112
abnormal gait 14 | 69
decreased body weight 14 | 161
decreased grip strength 14 | 116
increased bone mineral density 14 | 72
increased circulating choleste... 14 | 66
increased circulating HDL chol... 13 | 80
hypoactivity 12 | 132
increased circulating alkaline... 12 | 122
short tibia 12 | 97
abnormal seminal vesicle morph... 11 | 114
cataract 11 | 92
decreased circulating glucose ... 11 | 126
increased monocyte cell number 11 | 63
male infertility 11 | 123
small superior vagus ganglion 11 | 74
abnormal lens morphology 10 | 81
decreased circulating choleste... 10 | 93
decreased circulating serum al... 10 | 82
decreased fasted circulating g... 10 | 65
decreased prepulse inhibition 10 | 82
increased mean corpuscular vol... 10 | 92
increased neutrophil cell numb... 10 | 46
abnormal coat-hair pigmentatio... 9 | 64
abnormal cranium morphology 9 | 36
abnormal sleep behavior 9 | 70
decreased erythrocyte cell num... 9 | 62
decreased leukocyte cell numbe... 9 | 73
decreased mean corpuscular vol... 9 | 79
decreased startle reflex 9 | 75
impaired glucose tolerance 9 | 75
small testis 9 | 58
abnormal eye morphology 8 | 68
abnormal testis morphology 8 | 43
decreased circulating HDL chol... 8 | 68
decreased circulating triglyce... 8 | 79
edema 8 | 59
hydrometra 8 | 53
improved glucose tolerance 8 | 79
increased blood urea nitrogen ... 8 | 48
increased circulating sodium l... 8 | 71
increased mean corpuscular hem... 8 | 96
abnormal retina morphology 7 | 71
abnormal skin morphology 7 | 50
decreased circulating alkaline... 7 | 46
decreased circulating creatini... 7 | 39
decreased hematocrit 7 | 46
decreased mean corpuscular hem... 7 | 50
enlarged spleen 7 | 41
female infertility 7 | 60
increased circulating triglyce... 7 | 42
increased lymphocyte cell numb... 7 | 32
increased mean corpuscular hem... 7 | 36
increased red blood cell distr... 7 | 34
abnormal retinal blood vessel ... 6 | 26
abnormal snout morphology 6 | 23
abnormal tooth morphology 6 | 24
decreased blood urea nitrogen ... 6 | 51
decreased circulating calcium ... 6 | 36
decreased circulating total pr... 6 | 49
decreased mean corpuscular hem... 6 | 31
decreased neutrophil cell numb... 6 | 42
decreased red blood cell distr... 6 | 41
enlarged lymph nodes 6 | 37
impaired pupillary reflex 6 | 26
increased circulating phosphat... 6 | 26
increased fasted circulating g... 6 | 76
increased heart weight 6 | 62
increased mean platelet volume 6 | 45
limb grasping 6 | 41
thrombocytopenia 6 | 56
abnormal bone mineralization 5 | 38
abnormal locomotor behavior 5 | 24
decreased circulating LDL chol... 5 | 38
decreased circulating free fat... 5 | 31
decreased circulating insulin ... 5 | 76
increased prepulse inhibition 5 | 32
prenatal lethality prior to he... 5 | 87

Disease

group 4 medulloblastoma 1,806 | 1,806
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Endocrine System 1,784 | 18,159
Nervous System 1,778 | 16,725
Female tissues 1,769 | 17,400
Digestive Tract 1,765 | 17,369
Male tissues 1,763 | 17,142
Skin and soft tissues 1,761 | 17,230
Liver and Pancreas 1,750 | 16,750
Urinary Tract 1,746 | 16,678
Blood and immune system 1,744 | 16,909
Respiratory system 1,734 | 16,393
Cardiovascular System 1,673 | 15,192

Target Family

Non-IDG 1,018 | 12,091
Enzyme 402 | 4,145
Transcription Factor 172 | 1,400
Kinase 87 | 634
Transporter 40 | 473
Ion Channel 28 | 344
GPCR 26 | 408
Epigenetic 21 | 242
Nuclear Receptor 9 | 48
TF/Epigenetic 2 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
LIM homeobox transcription factor 1-alpha LMX1A Tbio Transcription Factor -1.82498 66.0 175
MyoD family inhibitor domain-containing protein MDFIC Tbio Non-IDG -2.90969 749.0 122
E3 ubiquitin-protein ligase MARCH6 MARCH6 Tbio Enzyme -1.67925 45.8 121
Zinc finger protein 675 ZNF675 Tbio Transcription Factor -1.55023 35.1 74
Serine/threonine-protein kinase D1 PRKD1 Tchem Kinase -2.88440 775.2 667
Neuronatin NNAT Tbio Non-IDG -1.98217 101.3 38
S-adenosylmethionine synthase isoform type-2 MAT2A Tbio Enzyme -1.91969 84.1 242
Tumor necrosis factor receptor superfamily member 1B TNFRSF1B Tchem Non-IDG -3.67481 4484.7 712
BAH and coiled-coil domain-containing protein 1 BAHCC1 Tbio Non-IDG 0.00000 0