1. Home
  2. Targets
Target Filters...

Development Level

Tbio 2,755 | 11,445
Tdark 806 | 6,588
Tchem 382 | 1,598
Tclin 161 | 613

Collection

RFA-RM-18-021 54 | 328
Ion Channel: IDG Consortium (T... 26 | 99
Kinase: IDG Consortium (Target... 20 | 125
GPCR: IDG Consortium (Targets) 8 | 126
Kinase: IDG Consortium (Comple... 6 | 37
GPCR: IDG Consortium (Complete... 3 | 25

IMPC Phenotype

preweaning lethality, complete... 260 | 979
preweaning lethality, incomple... 149 | 499
abnormal behavior 96 | 298
embryonic lethality prior to t... 78 | 278
decreased total body fat amoun... 66 | 207
embryonic lethality prior to o... 64 | 239
abnormal embryo size 59 | 220
increased lean body mass 54 | 172
decreased vertical activity 53 | 208
decreased body weight 51 | 161
hyperactivity 51 | 148
abnormal bone structure 49 | 187
enlarged heart 49 | 210
hypoactivity 47 | 132
increased bone mineral content 43 | 108
decreased bone mineral content 42 | 151
decreased lean body mass 42 | 135
decreased grip strength 38 | 116
increased startle reflex 38 | 112
increased total body fat amoun... 38 | 134
increased circulating alkaline... 35 | 122
abnormal heart morphology 34 | 162
decreased bone mineral density 34 | 126
male infertility 34 | 123
decreased circulating glucose ... 32 | 126
decreased circulating choleste... 30 | 93
decreased circulating serum al... 30 | 82
decreased startle reflex 28 | 75
cataract 26 | 92
decreased prepulse inhibition 26 | 82
increased mean corpuscular vol... 26 | 92
prenatal lethality prior to he... 26 | 87
abnormal seminal vesicle morph... 25 | 114
embryonic growth retardation 25 | 106
increased mean corpuscular hem... 25 | 96
increased or absent threshold ... 25 | 101
abnormal behavioral response t... 24 | 66
decreased body length 24 | 101
decreased circulating insulin ... 24 | 76
short tibia 24 | 97
decreased circulating HDL chol... 23 | 68
abnormal lens morphology 22 | 81
decreased circulating triglyce... 22 | 79
increased heart weight 22 | 62
decreased fasted circulating g... 20 | 65
decreased mean corpuscular vol... 20 | 79
abnormal gait 19 | 69
abnormal sleep behavior 19 | 70
decreased hemoglobin content 19 | 68
decreased lymphocyte cell numb... 19 | 83
increased bone mineral density 19 | 72
increased fasted circulating g... 19 | 76
abnormal retina morphology 18 | 71
decreased leukocyte cell numbe... 18 | 73
improved glucose tolerance 18 | 79
increased circulating HDL chol... 18 | 80
increased leukocyte cell numbe... 18 | 47
increased monocyte cell number 18 | 63
abnormal coat-hair pigmentatio... 17 | 64
abnormal eye morphology 17 | 68
abnormal kidney morphology 17 | 65
abnormal spleen morphology 17 | 55
thrombocytopenia 17 | 56
decreased caudal vertebrae num... 16 | 53
increased circulating sodium l... 16 | 71
increased hemoglobin content 16 | 45
small superior vagus ganglion 16 | 74
decreased circulating total pr... 15 | 49
decreased mean corpuscular hem... 15 | 50
impaired glucose tolerance 15 | 75
increased blood urea nitrogen ... 15 | 48
increased circulating chloride... 15 | 41
increased circulating triglyce... 15 | 42
tremors 15 | 39
decreased blood urea nitrogen ... 14 | 51
edema 14 | 59
female infertility 14 | 60
increased circulating creatini... 14 | 38
increased mean corpuscular hem... 14 | 36
decreased circulating LDL chol... 13 | 38
increased circulating calcium ... 13 | 34
limb grasping 13 | 41
abnormal neural tube closure 12 | 46
abnormal skin morphology 12 | 50
increased circulating choleste... 12 | 66
small testis 12 | 58
abnormal coat appearance 11 | 31
abnormal craniofacial morpholo... 11 | 33
abnormal cranium morphology 11 | 36
abnormal embryo turning 11 | 31
abnormal epididymis morphology 11 | 42
cardiovascular system phenotyp... 11 | 36
decreased circulating alanine ... 11 | 47
enlarged lymph nodes 11 | 37
enlarged spleen 11 | 41
increased grip strength 11 | 41
increased hematocrit 11 | 46
increased mean platelet volume 11 | 45
increased neutrophil cell numb... 11 | 46
prolonged ST segment 11 | 36

Disease

group 3 medulloblastoma 4,104 | 4,104
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 4,053 | 18,159
Nervous System 4,029 | 16,725
Digestive Tract 4,005 | 17,369
Skin and soft tissues 4,005 | 17,230
Female tissues 4,001 | 17,400
Male tissues 3,987 | 17,142
Liver and Pancreas 3,946 | 16,750
Blood and immune system 3,945 | 16,909
Urinary Tract 3,942 | 16,678
Respiratory system 3,897 | 16,393
Cardiovascular System 3,733 | 15,192

Target Family

Non-IDG 2,372 | 12,091
Enzyme 854 | 4,145
Transcription Factor 340 | 1,400
Kinase 168 | 634
Transporter 99 | 473
Ion Channel 92 | 344
Epigenetic 87 | 242
GPCR 62 | 408
Nuclear Receptor 14 | 48
TF/Epigenetic 13 | 38
oGPCR 3 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability