Targets

Target Filters...

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Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Androgen receptor	AR	Tclin	Nuclear Receptor	-3.82874	7137.7	1609
Cyclic AMP-responsive element-binding protein 1	CREB1	Tbio	Transcription Factor	-3.62610	3982.3	1574
Mitogen-activated protein kinase 14	MAPK14	Tchem	Kinase	-3.36007	2240.8	1574
Breast cancer type 1 susceptibility protein	BRCA1	Tchem	Non-IDG	-3.76784	6081.3	1542
Mothers against decapentaplegic homolog 3	SMAD3	Tbio	Transcription Factor	-3.19667	1403.6	1526
Forkhead box protein O1	FOXO1	Tbio	Transcription Factor	-3.05358	1143.3	1478
Eukaryotic translation initiation factor 4E-binding protein 1	EIF4EBP1	Tbio	Non-IDG	-2.83637	578.9	1455
Proliferation marker protein Ki-67	MKI67	Tbio	Non-IDG	-2.50106	270.3	1434
Platelet-derived growth factor receptor alpha	PDGFRA	Tclin	Kinase	-2.95012	809.9	1423
Chromogranin-A	CHGA	Tbio	Non-IDG	-3.36997	2235.2	1399

	Tbio	2,813 \| 11,651
	Tdark	806 \| 6,593
	Tchem	325 \| 1,388
	Tclin	160 \| 612

	RFA-RM-18-021	54 \| 328
	Ion Channel: IDG Consortium (T...	26 \| 99
	Kinase: IDG Consortium (Target...	20 \| 125
	GPCR: IDG Consortium (Targets)	8 \| 126
	Kinase: IDG Consortium (Comple...	6 \| 37
	GPCR: IDG Consortium (Complete...	3 \| 25

	preweaning lethality, complete...	260 \| 979
	preweaning lethality, incomple...	149 \| 499
	abnormal behavior	96 \| 298
	embryonic lethality prior to t...	78 \| 278
	decreased total body fat amoun...	66 \| 207
	embryonic lethality prior to o...	64 \| 239
	abnormal embryo size	59 \| 220
	increased lean body mass	54 \| 172
	decreased vertical activity	53 \| 208
	decreased body weight	51 \| 161
	hyperactivity	51 \| 148
	abnormal bone structure	49 \| 187
	enlarged heart	49 \| 210
	hypoactivity	47 \| 132
	increased bone mineral content	43 \| 108
	decreased bone mineral content	42 \| 151
	decreased lean body mass	42 \| 135
	decreased grip strength	38 \| 116
	increased startle reflex	38 \| 112
	increased total body fat amoun...	38 \| 134
	increased circulating alkaline...	35 \| 122
	abnormal heart morphology	34 \| 162
	decreased bone mineral density	34 \| 126
	male infertility	34 \| 123
	decreased circulating glucose ...	32 \| 126
	decreased circulating choleste...	30 \| 93
	decreased circulating serum al...	30 \| 82
	decreased startle reflex	28 \| 75
	cataract	26 \| 92
	decreased prepulse inhibition	26 \| 82
	increased mean corpuscular vol...	26 \| 92
	prenatal lethality prior to he...	26 \| 87
	abnormal seminal vesicle morph...	25 \| 114
	embryonic growth retardation	25 \| 106
	increased mean corpuscular hem...	25 \| 96
	increased or absent threshold ...	25 \| 101
	abnormal behavioral response t...	24 \| 66
	decreased body length	24 \| 101
	decreased circulating insulin ...	24 \| 76
	short tibia	24 \| 97
	decreased circulating HDL chol...	23 \| 68
	abnormal lens morphology	22 \| 81
	decreased circulating triglyce...	22 \| 79
	increased heart weight	22 \| 62
	decreased fasted circulating g...	20 \| 65
	decreased mean corpuscular vol...	20 \| 79
	abnormal gait	19 \| 69
	abnormal sleep behavior	19 \| 70
	decreased hemoglobin content	19 \| 68
	decreased lymphocyte cell numb...	19 \| 83
	increased bone mineral density	19 \| 72
	increased fasted circulating g...	19 \| 76
	abnormal retina morphology	18 \| 71
	decreased leukocyte cell numbe...	18 \| 73
	improved glucose tolerance	18 \| 79
	increased circulating HDL chol...	18 \| 80
	increased leukocyte cell numbe...	18 \| 47
	increased monocyte cell number	18 \| 63
	abnormal coat-hair pigmentatio...	17 \| 64
	abnormal eye morphology	17 \| 68
	abnormal kidney morphology	17 \| 65
	abnormal spleen morphology	17 \| 55
	thrombocytopenia	17 \| 56
	decreased caudal vertebrae num...	16 \| 53
	increased circulating sodium l...	16 \| 71
	increased hemoglobin content	16 \| 45
	small superior vagus ganglion	16 \| 74
	decreased circulating total pr...	15 \| 49
	decreased mean corpuscular hem...	15 \| 50
	impaired glucose tolerance	15 \| 75
	increased blood urea nitrogen ...	15 \| 48
	increased circulating chloride...	15 \| 41
	increased circulating triglyce...	15 \| 42
	tremors	15 \| 39
	decreased blood urea nitrogen ...	14 \| 51
	edema	14 \| 59
	female infertility	14 \| 60
	increased circulating creatini...	14 \| 38
	increased mean corpuscular hem...	14 \| 36
	decreased circulating LDL chol...	13 \| 38
	increased circulating calcium ...	13 \| 34
	limb grasping	13 \| 41
	abnormal neural tube closure	12 \| 46
	abnormal skin morphology	12 \| 50
	increased circulating choleste...	12 \| 66
	small testis	12 \| 58
	abnormal coat appearance	11 \| 31
	abnormal craniofacial morpholo...	11 \| 33
	abnormal cranium morphology	11 \| 36
	abnormal embryo turning	11 \| 31
	abnormal epididymis morphology	11 \| 42
	cardiovascular system phenotyp...	11 \| 36
	decreased circulating alanine ...	11 \| 47
	enlarged lymph nodes	11 \| 37
	enlarged spleen	11 \| 41
	increased grip strength	11 \| 41
	increased hematocrit	11 \| 46
	increased mean platelet volume	11 \| 45
	increased neutrophil cell numb...	11 \| 46
	prolonged ST segment	11 \| 36

	group 3 medulloblastoma	4,104 \| 4,104
	Carcinoma	11,493 \| 11,493
	ovarian cancer	8,520 \| 8,520
	osteosarcoma	7,950 \| 7,950
	psoriasis	6,694 \| 6,694
	medulloblastoma, large-cell	6,241 \| 6,241
	glioblastoma	5,792 \| 5,792
	atypical teratoid / rhabdoid tumor	5,112 \| 5,112
	lung cancer	4,740 \| 4,740
	ependymoma	4,679 \| 4,679
	adult high grade glioma	3,801 \| 3,801
	Breast cancer	3,578 \| 3,578
	intraductal papillary-mucinous neoplasm (IPMN)	3,291 \| 3,291
	malignant mesothelioma	3,232 \| 3,232
	Astrocytoma, Pilocytic	3,081 \| 3,081
	primitive neuroectodermal tumor	3,035 \| 3,035
	intraductal papillary-mucinous carcinoma (IPMC)	2,989 \| 2,989
	intraductal papillary-mucinous adenoma (IPMA)	2,955 \| 2,955
	invasive ductal carcinoma	2,951 \| 2,951
	non-small cell lung cancer	2,890 \| 2,890
	oligodendroglioma	2,850 \| 2,850
	lung carcinoma	2,843 \| 2,843
	lung adenocarcinoma	2,716 \| 2,716
	Kidney cancer	2,613 \| 2,613
	astrocytic glioma	2,597 \| 2,597
	Cancer	2,499 \| 2,499
	pancreatic cancer	2,398 \| 2,398
	interstitial cystitis	2,312 \| 2,312
	subependymal giant cell astrocytoma	2,287 \| 2,287
	tuberculosis	2,010 \| 2,010
	pituitary cancer	1,972 \| 1,972
	pancreatic ductal adenocarcinoma liver metastasis	1,962 \| 1,962
	Pick disease	1,894 \| 1,894
	group 4 medulloblastoma	1,855 \| 1,855
	ulcerative colitis	1,819 \| 1,819
	ductal carcinoma in situ	1,745 \| 1,745
	diabetes mellitus	1,728 \| 1,728
	cystic fibrosis	1,696 \| 1,696
	breast carcinoma	1,638 \| 1,638
	colon cancer	1,478 \| 1,478
	Autosomal recessive predisposition	1,442 \| 1,442
	adrenocortical carcinoma	1,428 \| 1,428
	Multiple myeloma	1,332 \| 1,332
	Rheumatoid arthritis	1,191 \| 1,191
	juvenile dermatomyositis	1,187 \| 1,187
	Schizophrenia	1,160 \| 1,160
	acute quadriplegic myopathy	1,158 \| 1,158
	astrocytoma	1,146 \| 1,146
	primary pancreatic ductal adenocarcinoma	1,109 \| 1,109
	spina bifida	1,074 \| 1,074
	pediatric high grade glioma	1,064 \| 1,064
	nasopharyngeal carcinoma	1,058 \| 1,058
	cutaneous lupus erythematosus	1,057 \| 1,057
	Intellectual disability	1,016 \| 1,016
	dermatomyositis	966 \| 966
	Atopic dermatitis	952 \| 952
	active Crohn's disease	922 \| 922
	non primary Sjogren syndrome sicca	891 \| 891
	gastric carcinoma	807 \| 807
	Epilepsy	792 \| 792
	acute myeloid leukemia	783 \| 783
	Liver Cirrhosis, Experimental	769 \| 769
	Waldenstrons macroglobulinemia	765 \| 765
	active ulcerative colitis	764 \| 764
	esophageal adenocarcinoma	737 \| 737
	primary Sjogren syndrome	735 \| 735
	medulloblastoma	720 \| 720
	Melanoma	711 \| 711
	Obesity	678 \| 678
	progressive supranuclear palsy	676 \| 676
	Bipolar Disorder	666 \| 666
	aldosterone-producing adenoma	665 \| 665
	Alzheimer's disease	658 \| 658
	Dull intelligence	645 \| 645
	Low intelligence	645 \| 645
	Mental Retardation	645 \| 645
	Mental deficiency	645 \| 645
	Poor school performance	645 \| 645
	Cognitive delay	608 \| 608
	Global developmental delay	608 \| 608
	Mental and motor retardation	608 \| 608
	Liver cancer	604 \| 604
	Duchenne muscular dystrophy	601 \| 601
	Seizures	596 \| 596
	Muscle hypotonia	571 \| 571
	pancreatic carcinoma	562 \| 562
	fibroadenoma	559 \| 559
	hepatocellular carcinoma	547 \| 547
	Endometriosis	540 \| 540
	Multiple Sclerosis	540 \| 540
	Short stature	531 \| 531
	chronic rhinosinusitis	512 \| 512
	autosomal dominant Emery-Dreifuss muscular dystrophy	510 \| 510
	Down syndrome	499 \| 499
	Prostatic Neoplasms	495 \| 495
	mucosa-associated lymphoid tissue lymphoma	484 \| 484
	Skin cancer	469 \| 469
	posterior fossa group A ependymoma	468 \| 468
	sonic hedgehog group medulloblastoma	467 \| 467
	gastric cancer	459 \| 459

	Endocrine System	4,053 \| 18,159
	Nervous System	4,029 \| 16,725
	Digestive Tract	4,005 \| 17,369
	Skin and soft tissues	4,005 \| 17,230
	Female tissues	4,001 \| 17,400
	Male tissues	3,987 \| 17,142
	Liver and Pancreas	3,946 \| 16,750
	Blood and immune system	3,945 \| 16,909
	Urinary Tract	3,942 \| 16,678
	Respiratory system	3,897 \| 16,393
	Cardiovascular System	3,733 \| 15,192

Development Level

Collection

IMPC Phenotype

Disease

Tissue

Target Family

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Data Source

	Non-IDG	2,372 \| 12,091
	Enzyme	854 \| 4,145
	Transcription Factor	340 \| 1,400
	Kinase	168 \| 634
	Transporter	99 \| 473
	Ion Channel	92 \| 344
	Epigenetic	87 \| 242
	GPCR	62 \| 408
	Nuclear Receptor	14 \| 48
	TF/Epigenetic	13 \| 38
	oGPCR	3 \| 421