Development Level

Tbio 226 | 10,625
Tdark 57 | 7,003
Tchem 48 | 1,890
Tclin 16 | 602

Collection

Eligible Ion Channel Proteins 6 | 117
Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 2 | 145

IMPC Term

preweaning lethality, complete... 17 | 633
embryonic lethality prior to t... 8 | 187
preweaning lethality, incomple... 8 | 260
decreased grip strength 7 | 123
abnormal behavior 6 | 226
decreased bone mineral content 5 | 157
decreased bone mineral density 4 | 126
decreased lean body mass 4 | 195
embryonic lethality prior to o... 4 | 148
enlarged heart 4 | 111
hyperactivity 4 | 108
increased body weight 4 | 42
decreased body length 3 | 108
decreased caudal vertebrae num... 3 | 49
decreased circulating alanine ... 3 | 53
decreased circulating serum al... 3 | 79
decreased total body fat amoun... 3 | 186
impaired glucose tolerance 3 | 52
increased bone mineral content 3 | 92
increased or absent threshold ... 3 | 128
short tibia 3 | 82
abnormal embryo size 2 | 112
abnormal facial morphology 2 | 9
abnormal heart morphology 2 | 51
abnormal neural tube closure 2 | 37
abnormal seminal vesicle morph... 2 | 47
abnormal spleen morphology 2 | 36
abnormal tibia morphology 2 | 14
cleft palate 2 | 6
decreased body weight 2 | 174
decreased circulating choleste... 2 | 85
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
decreased rib number 2 | 59
enlarged lymph nodes 2 | 27
increased circulating alkaline... 2 | 119
increased circulating calcium ... 2 | 32
increased circulating triglyce... 2 | 24
increased lean body mass 2 | 107
increased respiratory quotient 2 | 12
increased sacral vertebrae num... 2 | 62
long tibia 2 | 13
prenatal lethality prior to he... 2 | 64
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal craniofacial morpholo... 1 | 12
abnormal forebrain morphology 1 | 4
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal locomotor activation 1 | 26
abnormal lymph node morphology 1 | 3
abnormal pericardium morpholog... 1 | 11
abnormal sacral vertebrae morp... 1 | 5
abnormal tail morphology 1 | 17
abnormal vertebral arch morpho... 1 | 9
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
craniofacial phenotype 1 | 9
cyanosis 1 | 6
decreased CD4-positive, CD25-p... 1 | 24
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C low monocyte nu... 1 | 23
decreased NK cell number 1 | 16
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased kidney weight 1 | 7
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
hemorrhage 1 | 12
hypoactivity 1 | 89
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating choleste... 1 | 53
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
oligodactyly 1 | 14
polydactyly 1 | 22
small adrenal glands 1 | 15
small heart 1 | 8
straub tail 1 | 26
thrombocytopenia 1 | 46
vertebral transformation 1 | 12

Disease

glioblastoma multiforme 347 | 347
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 344 | 18,473
Endocrine System 344 | 18,512
Female tissues 344 | 18,647
Liver and Pancreas 344 | 18,136
Nervous System 344 | 18,561
Skin and soft tissues 344 | 18,115
Cardiovascular System 343 | 17,958
Male tissues 343 | 17,969
Urinary Tract 343 | 18,444
Blood and immune system 342 | 17,995
Respiratory system 342 | 17,484

Target Family

Non-IDG 192 | 11,969
Enzyme 76 | 4,146
Transcription Factor 29 | 1,400
GPCR 14 | 408
Kinase 14 | 634
Transporter 11 | 473
Ion Channel 8 | 341
Epigenetic 2 | 242
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Solute carrier family 35 member F5 SLC35F5 Tdark Transporter -0.16961 0.61 58
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 Tbio Enzyme -2.08075 121.5 75
RNA-binding protein 28 RBM28 Tbio Non-IDG -1.85274 73.2 99
Midnolin MIDN Tbio Non-IDG -1.13224 13.1 83
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 AGAP3 Tdark Enzyme -0.27300 2.02 126
Serine/threonine-protein kinase Nek6 NEK6 Tchem Kinase -1.52648 33.8 170
Oncostatin-M-specific receptor subunit beta OSMR Tbio Non-IDG -2.24105 170.5 217
Reticulon-4 receptor-like 2 RTN4RL2 Tbio Non-IDG -1.11442 14.6 64
N-terminal EF-hand calcium-binding protein 1 NECAB1 Tdark Non-IDG -0.31876 3.60 97
Dachshund homolog 2 DACH2 Tbio Non-IDG -0.93745 8.59 121