Development Level

Tbio 3,506 | 10,625
Tdark 1,167 | 7,003
Tchem 670 | 1,890
Tclin 229 | 602

Collection

Eligible Kinase Proteins 36 | 134
Eligible Ion Channel Proteins 33 | 117
Eligible non-olfactory GPCR Proteins 20 | 143

IMPC Term

preweaning lethality, complete... 188 | 633
preweaning lethality, incomple... 107 | 260
abnormal behavior 91 | 226
decreased lean body mass 89 | 195
decreased total body fat amoun... 82 | 186
decreased bone mineral content 73 | 157
embryonic lethality prior to t... 66 | 187
decreased body weight 65 | 174
abnormal bone structure 56 | 131
increased circulating alkaline... 56 | 119
decreased body length 52 | 108
hyperactivity 52 | 108
increased or absent threshold ... 52 | 128
decreased bone mineral density 50 | 126
embryonic lethality prior to o... 46 | 148
increased lean body mass 46 | 107
decreased grip strength 45 | 123
decreased circulating glucose ... 42 | 121
abnormal retina morphology 41 | 100
short tibia 41 | 82
enlarged heart 40 | 111
increased bone mineral content 40 | 92
decreased circulating choleste... 38 | 85
abnormal embryo size 37 | 112
hypoactivity 37 | 89
increased mean corpuscular vol... 36 | 91
decreased circulating HDL chol... 35 | 77
increased fasted circulating g... 32 | 68
abnormal lens morphology 31 | 73
decreased circulating triglyce... 30 | 83
increased mean corpuscular hem... 30 | 93
decreased prepulse inhibition 29 | 52
increased grip strength 28 | 83
abnormal sleep behavior 27 | 63
increased circulating HDL chol... 27 | 63
decreased circulating serum al... 26 | 79
improved glucose tolerance 26 | 56
abnormal gait 25 | 51
increased total body fat amoun... 25 | 57
male infertility 25 | 62
decreased circulating insulin ... 24 | 75
decreased fasted circulating g... 24 | 49
decreased startle reflex 24 | 48
increased circulating sodium l... 23 | 71
abnormal coat/hair pigmentatio... 22 | 54
increased circulating choleste... 22 | 53
abnormal bone mineralization 21 | 55
decreased heart weight 21 | 44
increased bone mineral density 21 | 52
increased sacral vertebrae num... 21 | 62
thrombocytopenia 21 | 46
decreased leukocyte cell numbe... 20 | 54
decreased mean corpuscular vol... 20 | 50
increased blood urea nitrogen ... 20 | 44
increased circulating chloride... 20 | 43
limb grasping 20 | 35
abnormal retinal pigmentation 19 | 61
decreased hemoglobin content 19 | 53
decreased rib number 19 | 59
abnormal heart morphology 18 | 51
cardiovascular system phenotyp... 18 | 35
decreased circulating alanine ... 18 | 53
decreased lumbar vertebrae num... 17 | 62
increased exploration in new e... 17 | 56
increased hemoglobin content 17 | 45
increased startle reflex 17 | 38
abnormal neural tube closure 16 | 37
cataract 16 | 26
decreased caudal vertebrae num... 16 | 49
impaired glucose tolerance 16 | 52
tremors 16 | 34
abnormal epididymis morphology 15 | 31
abnormal eye morphology 15 | 38
decreased circulating LDL chol... 15 | 37
decreased circulating alkaline... 15 | 41
decreased eosinophil cell numb... 15 | 41
decreased erythrocyte cell num... 15 | 43
increased body weight 15 | 42
increased heart weight 15 | 37
abnormal cranium morphology 14 | 32
decreased circulating amylase ... 14 | 24
decreased circulating calcium ... 14 | 33
increased circulating calcium ... 14 | 32
increased circulating phosphat... 14 | 24
increased circulating potassiu... 14 | 31
abnormal hindbrain development 13 | 24
abnormal kidney morphology 13 | 30
abnormal tooth morphology 13 | 24
decreased circulating creatini... 13 | 31
decreased mean corpuscular hem... 13 | 34
decreased threshold for audito... 13 | 32
increased circulating iron lev... 13 | 25
increased erythrocyte cell num... 13 | 26
increased hematocrit 13 | 36
increased mean corpuscular hem... 13 | 25
decreased NK T cell number 12 | 28
female infertility 12 | 34
increased rib number 12 | 41
prenatal lethality prior to he... 12 | 64
small testis 12 | 37

Disease

glioblastoma 5,572 | 5,572
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 5,525 | 18,561
Female tissues 5,519 | 18,647
Digestive Tract 5,517 | 18,473
Liver and Pancreas 5,513 | 18,136
Urinary Tract 5,508 | 18,444
Endocrine System 5,505 | 18,512
Cardiovascular System 5,502 | 17,958
Blood and immune system 5,499 | 17,995
Male tissues 5,498 | 17,969
Skin and soft tissues 5,470 | 18,115
Respiratory system 5,463 | 17,484

Target Family

Non-IDG 3,276 | 11,971
Enzyme 1,199 | 4,146
Transcription Factor 366 | 1,400
Kinase 238 | 634
Transporter 160 | 473
Ion Channel 124 | 341
GPCR 92 | 406
Epigenetic 88 | 242
Nuclear Receptor 14 | 48
TF/Epigenetic 13 | 38
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89