Development Level

Tbio 3,958 | 11,651
Tdark 1,052 | 6,593
Tchem 541 | 1,388
Tclin 241 | 612

Collection

RFA-RM-18-021 90 | 328
Kinase: IDG Consortium (Target... 39 | 125
Ion Channel: IDG Consortium (T... 32 | 99
GPCR: IDG Consortium (Targets) 20 | 126
Kinase: IDG Consortium (Comple... 14 | 37
GPCR: IDG Consortium (Complete... 6 | 25

IMPC Phenotype

preweaning lethality, complete... 299 | 979
preweaning lethality, incomple... 211 | 499
abnormal behavior 127 | 298
decreased total body fat amoun... 101 | 207
embryonic lethality prior to t... 94 | 278
abnormal bone structure 85 | 187
abnormal embryo size 80 | 220
increased lean body mass 78 | 172
embryonic lethality prior to o... 71 | 239
decreased bone mineral content 69 | 151
decreased vertical activity 69 | 208
hyperactivity 69 | 148
enlarged heart 66 | 210
decreased body weight 60 | 161
increased circulating alkaline... 59 | 122
hypoactivity 58 | 132
decreased lean body mass 56 | 135
increased bone mineral content 56 | 108
decreased grip strength 53 | 116
increased total body fat amoun... 53 | 134
decreased body length 50 | 101
decreased bone mineral density 49 | 126
decreased circulating glucose ... 46 | 126
abnormal heart morphology 43 | 162
increased startle reflex 43 | 112
male infertility 40 | 123
short tibia 40 | 97
cataract 39 | 92
decreased lymphocyte cell numb... 39 | 83
decreased prepulse inhibition 38 | 82
abnormal lens morphology 37 | 81
increased mean corpuscular vol... 37 | 92
decreased circulating choleste... 36 | 93
improved glucose tolerance 36 | 79
abnormal gait 35 | 69
decreased mean corpuscular vol... 35 | 79
embryonic growth retardation 35 | 106
increased fasted circulating g... 35 | 76
increased or absent threshold ... 34 | 101
abnormal seminal vesicle morph... 33 | 114
increased circulating HDL chol... 33 | 80
decreased fasted circulating g... 32 | 65
decreased startle reflex 32 | 75
increased bone mineral density 32 | 72
increased circulating choleste... 32 | 66
increased mean corpuscular hem... 30 | 96
abnormal sleep behavior 28 | 70
decreased circulating HDL chol... 27 | 68
decreased circulating triglyce... 27 | 79
impaired glucose tolerance 27 | 75
abnormal kidney morphology 26 | 65
decreased circulating serum al... 26 | 82
decreased hemoglobin content 26 | 68
decreased leukocyte cell numbe... 26 | 73
increased heart weight 26 | 62
increased monocyte cell number 26 | 63
abnormal eye morphology 25 | 68
abnormal behavioral response t... 24 | 66
increased circulating sodium l... 24 | 71
limb grasping 24 | 41
small testis 24 | 58
abnormal retina morphology 23 | 71
decreased circulating insulin ... 23 | 76
abnormal coat-hair pigmentatio... 22 | 64
decreased erythrocyte cell num... 21 | 62
increased circulating chloride... 21 | 41
increased neutrophil cell numb... 21 | 46
small superior vagus ganglion 21 | 74
thrombocytopenia 21 | 56
abnormal epididymis morphology 20 | 42
decreased mean corpuscular hem... 20 | 50
edema 20 | 59
female infertility 20 | 60
increased circulating triglyce... 20 | 42
increased hematocrit 20 | 46
prenatal lethality prior to he... 20 | 87
abnormal spleen morphology 19 | 55
decreased circulating alanine ... 19 | 47
decreased hematocrit 19 | 46
increased blood urea nitrogen ... 19 | 48
increased leukocyte cell numbe... 19 | 47
increased mean platelet volume 19 | 45
decreased blood urea nitrogen ... 18 | 51
decreased caudal vertebrae num... 18 | 53
decreased neutrophil cell numb... 18 | 42
increased mean corpuscular hem... 18 | 36
tremors 18 | 39
abnormal cranium morphology 17 | 36
cardiovascular system phenotyp... 17 | 36
decreased circulating alkaline... 17 | 46
increased erythrocyte cell num... 17 | 39
abnormal skin morphology 16 | 50
decreased circulating calcium ... 16 | 36
decreased mean corpuscular hem... 16 | 31
enlarged lymph nodes 16 | 37
enlarged spleen 16 | 41
increased circulating calcium ... 16 | 34
increased hemoglobin content 16 | 45
prolonged QT interval 15 | 38
prolonged ST segment 15 | 36

Disease

glioblastoma 5,792 | 5,792
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 5,723 | 18,159
Nervous System 5,693 | 16,725
Female tissues 5,670 | 17,400
Digestive Tract 5,666 | 17,369
Skin and soft tissues 5,652 | 17,230
Male tissues 5,640 | 17,142
Liver and Pancreas 5,585 | 16,750
Urinary Tract 5,577 | 16,678
Blood and immune system 5,562 | 16,909
Respiratory system 5,520 | 16,393
Cardiovascular System 5,298 | 15,192

Target Family

Non-IDG 3,396 | 12,091
Enzyme 1,243 | 4,145
Transcription Factor 383 | 1,400
Kinase 251 | 634
Transporter 170 | 473
Ion Channel 130 | 344
GPCR 99 | 408
Epigenetic 90 | 242
Nuclear Receptor 15 | 48
TF/Epigenetic 13 | 38
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418