Development Level

Tbio 538 | 10,625
Tdark 132 | 7,003
Tchem 126 | 1,890
Tclin 36 | 602

Collection

GPCR: IDG Consortium (Targets) 4 | 127
Ion Channel: IDG Consortium (Targets) 4 | 102
GPCR: IDG Consortium (Complete/Control) 3 | 26
Kinase: IDG Consortium (Targets) 3 | 125
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 22 | 633
preweaning lethality, incomple... 15 | 260
abnormal behavior 13 | 226
decreased body weight 12 | 174
decreased total body fat amoun... 11 | 186
decreased lean body mass 9 | 195
decreased grip strength 8 | 123
hypoactivity 8 | 89
abnormal embryo size 7 | 112
decreased body length 7 | 108
decreased bone mineral content 7 | 157
enlarged heart 7 | 111
increased bone mineral content 7 | 92
increased bone mineral density 7 | 52
increased fasted circulating g... 7 | 68
increased mean corpuscular vol... 7 | 91
abnormal bone structure 6 | 131
decreased bone mineral density 6 | 126
decreased circulating glucose ... 6 | 121
decreased circulating insulin ... 6 | 75
increased lean body mass 6 | 107
short tibia 6 | 82
abnormal coat-hair pigmentatio... 5 | 54
abnormal gait 5 | 51
abnormal retina morphology 5 | 100
decreased circulating serum al... 5 | 79
embryonic lethality prior to t... 5 | 187
increased circulating alkaline... 5 | 119
increased exploration in new e... 5 | 56
increased sacral vertebrae num... 5 | 62
abnormal bone mineralization 4 | 55
abnormal femur morphology 4 | 14
abnormal lens morphology 4 | 73
decreased circulating chloride... 4 | 32
decreased lumbar vertebrae num... 4 | 62
decreased threshold for audito... 4 | 32
female infertility 4 | 34
impaired glucose tolerance 4 | 52
increased circulating chloride... 4 | 43
increased mean corpuscular hem... 4 | 93
increased or absent threshold ... 4 | 128
thrombocytopenia 4 | 46
abnormal QRS complex 3 | 25
abnormal facial morphology 3 | 9
abnormal heart morphology 3 | 51
abnormal humerus morphology 3 | 11
abnormal limb morphology 3 | 7
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
abnormal sleep behavior 3 | 63
abnormal tail morphology 3 | 17
abnormal tibia morphology 3 | 14
abnormal tooth morphology 3 | 24
decreased caudal vertebrae num... 3 | 49
decreased circulating HDL chol... 3 | 77
decreased circulating alanine ... 3 | 53
decreased circulating choleste... 3 | 85
decreased circulating glycerol... 3 | 19
decreased circulating potassiu... 3 | 17
decreased heart weight 3 | 44
decreased prepulse inhibition 3 | 52
decreased rib number 3 | 59
embryonic lethality prior to o... 3 | 148
improved glucose tolerance 3 | 56
increased B cell number 3 | 23
increased body weight 3 | 42
increased circulating HDL chol... 3 | 63
increased circulating fructosa... 3 | 11
increased circulating glucose ... 3 | 16
increased circulating sodium l... 3 | 71
increased circulating total pr... 3 | 20
increased circulating triglyce... 3 | 24
increased grip strength 3 | 83
increased hematocrit 3 | 36
increased mature B cell number 3 | 12
increased mean corpuscular hem... 3 | 25
polydactyly 3 | 22
tremors 3 | 34
abnormal behavioral response t... 2 | 52
abnormal body wall morphology 2 | 7
abnormal coat appearance 2 | 25
abnormal head morphology 2 | 10
abnormal optic disc morphology 2 | 10
abnormal spleen morphology 2 | 36
abnormal vertebrae morphology 2 | 14
convulsive seizures 2 | 11
decreased T cell number 2 | 31
decreased circulating iron lev... 2 | 25
decreased mean corpuscular vol... 2 | 50
embryonic growth retardation 2 | 28
enlarged spleen 2 | 26
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 32
increased circulating choleste... 2 | 53
increased circulating potassiu... 2 | 31
increased circulating serum al... 2 | 25
increased hemoglobin content 2 | 45
increased respiratory quotient 2 | 12
increased total body fat amoun... 2 | 57
vertebral fusion 2 | 23

Disease

gastric carcinoma 832 | 832
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 824 | 18,472
Liver and Pancreas 824 | 18,135
Nervous System 824 | 18,560
Endocrine System 823 | 18,511
Female tissues 823 | 18,646
Urinary Tract 822 | 18,443
Cardiovascular System 821 | 17,957
Blood and immune system 820 | 17,994
Male tissues 820 | 17,968
Respiratory system 820 | 17,483
Skin and soft tissues 820 | 18,114

Target Family

Non-IDG 489 | 11,969
Enzyme 205 | 4,146
Transcription Factor 47 | 1,400
Kinase 27 | 634
GPCR 20 | 408
Transporter 20 | 473
Ion Channel 16 | 341
Epigenetic 6 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Protein fosB FOSB Tbio Transcription Factor -2.64139 409.7 306
Angiopoietin-related protein 2 ANGPTL2 Tbio Non-IDG -1.74019 67.9 132
ERBB receptor feedback inhibitor 1 ERRFI1 Tbio Non-IDG -1.84249 72.2 131
Protein quaking QKI Tbio Non-IDG -1.81649 63.7 254
Transmembrane emp24 domain-containing protein 6 TMED6 Tdark Non-IDG -0.21085 1.53 63
A-kinase anchor protein 12 AKAP12 Tbio Enzyme -1.97288 119.1 151
Extracellular tyrosine-protein kinase PKDCC PKDCC Tbio Kinase -1.14420 14.3 48