Development Level

Tbio 275 | 10,625
Tdark 91 | 7,003
Tchem 51 | 1,890
Tclin 19 | 602

Collection

Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 18 | 633
preweaning lethality, incomple... 10 | 260
decreased lean body mass 6 | 195
decreased circulating triglyce... 5 | 83
decreased total body fat amoun... 5 | 186
thrombocytopenia 5 | 46
decreased body weight 4 | 174
decreased leukocyte cell numbe... 4 | 54
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
abnormal behavior 3 | 226
abnormal bone structure 3 | 131
abnormal epididymis morphology 3 | 31
decreased CD4-positive, CD25-p... 3 | 24
decreased NK T cell number 3 | 28
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating LDL chol... 3 | 37
decreased circulating glucose ... 3 | 121
decreased circulating insulin ... 3 | 75
decreased erythrocyte cell num... 3 | 43
decreased hemoglobin content 3 | 53
decreased rib number 3 | 59
embryonic lethality prior to t... 3 | 187
enlarged epididymis 3 | 27
impaired glucose tolerance 3 | 52
increased body weight 3 | 42
increased circulating alkaline... 3 | 119
increased fasted circulating g... 3 | 68
increased heart weight 3 | 37
increased lean body mass 3 | 107
abnormal coat/hair pigmentatio... 2 | 54
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
abnormal retinal blood vessel ... 2 | 18
abnormal retinal vasculature m... 2 | 15
abnormal rib morphology 2 | 28
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
corneal opacity 2 | 25
decreased CD8-positive, alpha-... 2 | 26
decreased Ly6C-positive mature... 2 | 4
decreased circulating choleste... 2 | 85
decreased granulocyte number 2 | 8
decreased heart rate 2 | 10
decreased hematocrit 2 | 25
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
female infertility 2 | 34
improved glucose tolerance 2 | 56
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating calcium ... 2 | 32
increased circulating choleste... 2 | 53
increased circulating total pr... 2 | 20
increased monocyte cell number 2 | 27
increased rib number 2 | 41
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
male infertility 2 | 62
narrow eye opening 2 | 15
short tibia 2 | 82
vertebral fusion 2 | 23
abnormal behavioral response t... 1 | 52
abnormal cranium morphology 1 | 32
abnormal locomotor activation 1 | 26
abnormal skin morphology 1 | 23
abnormal snout morphology 1 | 18
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
absent teeth 1 | 4
decreased IgG1 level 1 | 4
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased gamma-delta T cell n... 1 | 18
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
hydrometra 1 | 13
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating glycerol... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating triglyce... 1 | 24
increased mean corpuscular hem... 1 | 25
increased startle reflex 1 | 38
limb grasping 1 | 35
long tibia 1 | 13
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
prolonged RR interval 1 | 2

Disease

gastric cancer 436 | 436
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 431 | 17,995
Liver and Pancreas 431 | 18,136
Male tissues 430 | 17,969
Cardiovascular System 429 | 17,958
Digestive Tract 429 | 18,473
Endocrine System 429 | 18,512
Female tissues 429 | 18,647
Nervous System 429 | 18,561
Urinary Tract 429 | 18,444
Respiratory system 428 | 17,484
Skin and soft tissues 425 | 18,115

Target Family

Non-IDG 240 | 11,969
Enzyme 110 | 4,146
Transcription Factor 43 | 1,400
Kinase 12 | 634
Transporter 10 | 473
Epigenetic 7 | 242
GPCR 4 | 408
Ion Channel 4 | 341
Nuclear Receptor 4 | 48
TF/Epigenetic 2 | 38

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