Development Level

Tbio 366 | 11,178
Tdark 79 | 6,569
Tchem 60 | 1,885
Tclin 33 | 612

Collection

Ion Channel: IDG Consortium (T... 4 | 99
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 2 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 21 | 979
abnormal behavior 14 | 298
decreased vertical activity 13 | 208
hyperactivity 10 | 148
preweaning lethality, incomple... 9 | 499
embryonic lethality prior to t... 8 | 278
abnormal bone structure 7 | 187
abnormal heart morphology 7 | 162
decreased body weight 7 | 161
decreased total body fat amoun... 7 | 207
enlarged heart 7 | 210
hypoactivity 7 | 132
increased lean body mass 6 | 172
increased mean corpuscular vol... 6 | 92
increased total body fat amoun... 6 | 134
abnormal embryo size 5 | 220
abnormal gait 5 | 69
abnormal lens morphology 5 | 81
decreased circulating choleste... 5 | 93
decreased circulating serum al... 5 | 82
decreased fasted circulating g... 5 | 65
decreased prepulse inhibition 5 | 82
decreased startle reflex 5 | 75
increased fasted circulating g... 5 | 76
increased neutrophil cell numb... 5 | 46
abnormal sleep behavior 4 | 70
decreased bone mineral content 4 | 151
decreased bone mineral density 4 | 126
decreased circulating amylase ... 4 | 28
decreased circulating glucose ... 4 | 126
decreased circulating triglyce... 4 | 79
decreased grip strength 4 | 116
decreased mean corpuscular vol... 4 | 79
increased bone mineral content 4 | 108
increased heart weight 4 | 62
increased or absent threshold ... 4 | 101
small superior vagus ganglion 4 | 74
abnormal behavioral response t... 3 | 66
abnormal coat-hair pigmentatio... 3 | 64
abnormal cranium morphology 3 | 36
abnormal eye morphology 3 | 68
abnormal kidney morphology 3 | 65
abnormal retina morphology 3 | 71
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
abnormal spleen morphology 3 | 55
cardiovascular system phenotyp... 3 | 36
decreased CD4-positive, alpha ... 3 | 7
decreased T cell number 3 | 15
decreased circulating insulin ... 3 | 76
decreased circulating total pr... 3 | 49
decreased lymphocyte cell numb... 3 | 83
decreased neutrophil cell numb... 3 | 42
embryonic lethality prior to o... 3 | 239
female infertility 3 | 60
hydrometra 3 | 53
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased circulating HDL chol... 3 | 80
increased circulating choleste... 3 | 66
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 96
limb grasping 3 | 41
male infertility 3 | 123
prenatal lethality prior to he... 3 | 87
abnormal bone mineralization 2 | 38
abnormal ear morphology 2 | 9
abnormal head morphology 2 | 10
abnormal limb bud morphology 2 | 17
abnormal neural tube closure 2 | 46
abnormal snout morphology 2 | 23
abnormal startle reflex 2 | 15
abnormal whole-body plethysmog... 2 | 4
corneal opacity 2 | 32
decreased IgG1 level 2 | 8
decreased circulating alanine ... 2 | 47
decreased circulating alkaline... 2 | 46
decreased circulating fructosa... 2 | 30
decreased hemoglobin content 2 | 68
decreased red blood cell distr... 2 | 41
edema 2 | 59
enlarged uterus 2 | 11
increased blood urea nitrogen ... 2 | 48
increased blood uric acid leve... 2 | 5
increased circulating alkaline... 2 | 122
increased circulating amylase ... 2 | 25
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating phosphat... 2 | 26
increased circulating serum al... 2 | 22
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 32
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
microphthalmia 2 | 26
pallor 2 | 34
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
short tibia 2 | 97

Disease

fibroadenoma 538 | 538
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Endocrine System 535 | 18,159
Female tissues 535 | 17,400
Digestive Tract 534 | 17,369
Male tissues 534 | 17,142
Skin and soft tissues 534 | 17,230
Blood and immune system 532 | 16,909
Liver and Pancreas 531 | 16,750
Urinary Tract 531 | 16,678
Respiratory system 528 | 16,393
Nervous System 526 | 16,725
Cardiovascular System 509 | 15,192

Target Family

Non-IDG 325 | 12,091
Enzyme 116 | 4,145
Transcription Factor 32 | 1,400
Kinase 25 | 634
GPCR 14 | 408
Transporter 14 | 473
Ion Channel 9 | 344
Nuclear Receptor 3 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Kazal-type serine protease inhibitor domain-containing protein 1 KAZALD1 Tdark Enzyme -0.50068 4.33 42
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148
Prominin-2 PROM2 Tbio Non-IDG -1.12562 11.0 199
Cysteine and glycine-rich protein 2 CSRP2 Tbio Non-IDG -0.96898 10.3 178
Leucine-rich repeat LGI family member 4 LGI4 Tbio Non-IDG -0.95884 8.52 114
Pirin PIR Tchem Non-IDG -2.72312 503.8 154
GTP-binding protein Di-Ras1 DIRAS1 Tbio Enzyme -0.70186 0.00000 175
Serine/threonine-protein kinase MARK1 MARK1 Tchem Kinase -1.77236 56.1 318
Zinc finger E-box-binding homeobox 2 ZEB2 Tbio Transcription Factor -2.49656 262.6 474
Beta-2 adrenergic receptor ADRB2 Tclin GPCR -3.22695 1680.9 829