Development Level

Tbio 134 | 10,625
Tdark 110 | 7,003
Tchem 28 | 1,890
Tclin 14 | 602

Collection

Eligible Ion Channel Proteins 2 | 117
Eligible Kinase Proteins 2 | 134
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 7 | 633
decreased body weight 3 | 174
decreased lean body mass 3 | 195
decreased lumbar vertebrae num... 3 | 62
decreased prepulse inhibition 3 | 52
decreased startle reflex 3 | 48
hyperactivity 3 | 108
limb grasping 3 | 35
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
absent startle reflex 2 | 15
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
improved glucose tolerance 2 | 56
increased blood urea nitrogen ... 2 | 44
increased circulating HDL chol... 2 | 63
increased sacral vertebrae num... 2 | 62
mydriasis 2 | 9
abnormal QRS complex 1 | 25
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal craniofacial morpholo... 1 | 12
abnormal ear morphology 1 | 5
abnormal epididymis morphology 1 | 31
abnormal eye anterior chamber ... 1 | 3
abnormal eye morphology 1 | 38
abnormal forebrain morphology 1 | 4
abnormal heart left ventricle ... 1 | 20
abnormal locomotor activation 1 | 26
abnormal male genitalia morpho... 1 | 1
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
cyanosis 1 | 6
cystolithiasis 1 | 1
decreased CD4-positive, CD25-p... 1 | 24
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased hematocrit 1 | 25
decreased neutrophil cell numb... 1 | 37
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
embryonic lethality prior to t... 1 | 187
hemorrhage 1 | 12
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired pupillary reflex 1 | 14
impaired righting response 1 | 19
increased CD4-positive, CD25-p... 1 | 18
increased Ly6C high monocyte n... 1 | 12
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased caudal vertebrae num... 1 | 8
increased circulating amylase ... 1 | 13
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased heart weight 1 | 37
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
irregularly shaped pupil 1 | 7
oligodactyly 1 | 14
polycystic kidney 1 | 9
polydactyly 1 | 22
preweaning lethality, incomple... 1 | 260
straub tail 1 | 26

Disease

facioscapulohumeral dystrophy 286 | 286
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Endocrine System 263 | 18,512
Digestive Tract 259 | 18,473
Skin and soft tissues 259 | 18,115
Female tissues 258 | 18,647
Nervous System 258 | 18,561
Urinary Tract 257 | 18,444
Liver and Pancreas 251 | 18,136
Cardiovascular System 246 | 17,958
Male tissues 246 | 17,969
Blood and immune system 243 | 17,995
Respiratory system 231 | 17,484

Target Family

Non-IDG 162 | 11,971
Enzyme 50 | 4,146
Transcription Factor 34 | 1,400
Transporter 14 | 473
Kinase 10 | 634
GPCR 7 | 406
Ion Channel 5 | 341
Epigenetic 2 | 242
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interferon lambda receptor 1 IFNLR1 Tchem Non-IDG -1.48464 33.1 128
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
Zinc finger protein 705D ZNF705D Tdark Transcription Factor 0.00000 3
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104
Tripartite motif-containing protein 48 TRIM48 Tdark Non-IDG 0.00000 64
Ret finger protein-like 4B RFPL4B Tdark Non-IDG 0.00000 76
Polypeptide N-acetylgalactosaminyltransferase 18 GALNT18 Tdark Enzyme -0.28065 3.03 33
G-protein coupled receptor 4 GPR4 Tchem GPCR -1.57104 43.8 104
Protein FAM9B FAM9B Tdark Non-IDG -0.01424 0.64 22
E3 ubiquitin-protein ligase TRIM71 TRIM71 Tbio Enzyme -1.30174 21.0 114