Development Level

Tbio 512 | 10,625
Tchem 124 | 1,890
Tdark 69 | 7,003
Tclin 32 | 602

Collection

Eligible non-olfactory GPCR Proteins 7 | 143
Eligible Ion Channel Proteins 4 | 117
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 26 | 633
decreased lean body mass 18 | 195
decreased total body fat amoun... 16 | 186
decreased bone mineral content 15 | 157
preweaning lethality, incomple... 14 | 260
decreased circulating glucose ... 13 | 121
decreased body weight 12 | 174
abnormal behavior 11 | 226
increased bone mineral content 11 | 92
decreased body length 10 | 108
decreased bone mineral density 9 | 126
decreased circulating HDL chol... 9 | 77
increased circulating alkaline... 9 | 119
increased lean body mass 9 | 107
abnormal bone structure 8 | 131
increased mean corpuscular vol... 8 | 91
abnormal lens morphology 7 | 73
decreased circulating choleste... 7 | 85
decreased circulating serum al... 7 | 79
decreased rib number 7 | 59
improved glucose tolerance 7 | 56
abnormal gait 6 | 51
decreased circulating insulin ... 6 | 75
decreased circulating triglyce... 6 | 83
decreased hemoglobin content 6 | 53
decreased mean corpuscular vol... 6 | 50
embryonic lethality prior to t... 6 | 187
hyperactivity 6 | 108
increased circulating sodium l... 6 | 71
increased or absent threshold ... 6 | 128
short tibia 6 | 82
abnormal coat/hair pigmentatio... 5 | 54
cataract 5 | 26
decreased circulating fructosa... 5 | 31
decreased heart weight 5 | 44
decreased lumbar vertebrae num... 5 | 62
decreased prepulse inhibition 5 | 52
increased circulating total pr... 5 | 20
increased grip strength 5 | 83
increased red blood cell distr... 5 | 21
limb grasping 5 | 35
abnormal retina morphology 4 | 100
abnormal rib morphology 4 | 28
abnormal sleep behavior 4 | 63
abnormal tooth morphology 4 | 24
decreased erythrocyte cell num... 4 | 43
decreased grip strength 4 | 123
embryonic lethality prior to o... 4 | 148
enlarged lymph nodes 4 | 27
increased bone mineral density 4 | 52
increased circulating creatini... 4 | 29
increased circulating free fat... 4 | 17
increased mean corpuscular hem... 4 | 93
increased rib number 4 | 41
increased sacral vertebrae num... 4 | 62
increased startle reflex 4 | 38
tremors 4 | 34
abnormal behavioral response t... 3 | 52
abnormal bone mineralization 3 | 55
abnormal embryo size 3 | 112
abnormal kidney morphology 3 | 30
abnormal locomotor activation 3 | 26
abnormal pelvic girdle bone mo... 3 | 11
cardiovascular system phenotyp... 3 | 35
decreased blood urea nitrogen ... 3 | 31
decreased circulating alanine ... 3 | 53
decreased circulating alkaline... 3 | 41
decreased circulating glycerol... 3 | 19
decreased eosinophil cell numb... 3 | 41
decreased fasted circulating g... 3 | 49
decreased hematocrit 3 | 25
decreased mean corpuscular hem... 3 | 34
enlarged heart 3 | 111
impaired righting response 3 | 19
increased blood urea nitrogen ... 3 | 44
increased circulating calcium ... 3 | 32
increased circulating chloride... 3 | 43
increased circulating potassiu... 3 | 31
increased exploration in new e... 3 | 56
increased heart rate 3 | 17
increased heart weight 3 | 37
increased hemoglobin content 3 | 45
increased mean platelet volume 3 | 19
male infertility 3 | 62
prenatal lethality prior to he... 3 | 64
shortened RR interval 3 | 19
abnormal coat appearance 2 | 25
abnormal epididymis morphology 2 | 31
abnormal lung morphology 2 | 15
abnormal vibrissa morphology 2 | 17
decreased T cell number 2 | 31
decreased caudal vertebrae num... 2 | 49
decreased circulating calcium ... 2 | 33
decreased circulating potassiu... 2 | 17
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased body length 2 | 20
increased body weight 2 | 42
increased circulating bilirubi... 2 | 16
thrombocytopenia 2 | 46

Disease

esophageal adenocarcinoma 737 | 737
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 734 | 18,473
Female tissues 734 | 18,647
Liver and Pancreas 734 | 18,136
Nervous System 733 | 18,561
Urinary Tract 733 | 18,444
Blood and immune system 732 | 17,995
Endocrine System 732 | 18,512
Cardiovascular System 731 | 17,958
Male tissues 730 | 17,969
Respiratory system 729 | 17,484
Skin and soft tissues 729 | 18,115

Target Family

Non-IDG 431 | 11,971
Enzyme 180 | 4,146
Transcription Factor 41 | 1,400
Kinase 36 | 634
GPCR 15 | 406
Transporter 14 | 473
Ion Channel 10 | 341
Nuclear Receptor 5 | 48
Epigenetic 3 | 242
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Inactive phospholipase C-like protein 2 PLCL2 Tbio Enzyme -0.27372 2.11 81
E3 ubiquitin-protein ligase TRIM31 TRIM31 Tbio Enzyme -2.12276 133.1 126
Cysteine-rich protein 2 CRIP2 Tbio Non-IDG -0.95386 10.4 115