Development Level

Tbio 1,541 | 10,625
Tdark 585 | 7,003
Tchem 288 | 1,890
Tclin 100 | 602

Collection

Eligible Kinase Proteins 26 | 134
Eligible Ion Channel Proteins 23 | 117
Eligible non-olfactory GPCR Proteins 10 | 143

IMPC Term

preweaning lethality, complete... 83 | 633
abnormal behavior 52 | 226
preweaning lethality, incomple... 50 | 260
decreased total body fat amoun... 41 | 186
embryonic lethality prior to t... 36 | 187
decreased lean body mass 34 | 195
decreased body weight 32 | 174
decreased bone mineral content 28 | 157
hyperactivity 24 | 108
decreased circulating choleste... 22 | 85
decreased circulating triglyce... 22 | 83
decreased body length 21 | 108
decreased circulating HDL chol... 21 | 77
increased circulating alkaline... 21 | 119
increased lean body mass 21 | 107
decreased bone mineral density 20 | 126
embryonic lethality prior to o... 20 | 148
hypoactivity 20 | 89
abnormal retina morphology 19 | 100
decreased grip strength 19 | 123
increased or absent threshold ... 19 | 128
abnormal bone structure 18 | 131
decreased circulating serum al... 17 | 79
abnormal embryo size 16 | 112
decreased circulating glucose ... 16 | 121
enlarged heart 16 | 111
increased mean corpuscular hem... 16 | 93
increased bone mineral content 15 | 92
increased mean corpuscular vol... 15 | 91
male infertility 13 | 62
abnormal gait 12 | 51
abnormal lens morphology 12 | 73
decreased circulating LDL chol... 12 | 37
abnormal bone mineralization 11 | 55
decreased circulating calcium ... 11 | 33
decreased prepulse inhibition 11 | 52
increased circulating sodium l... 11 | 71
increased grip strength 11 | 83
increased sacral vertebrae num... 11 | 62
short tibia 11 | 82
abnormal coat/hair pigmentatio... 10 | 54
abnormal sleep behavior 10 | 63
decreased circulating alanine ... 10 | 53
decreased circulating insulin ... 10 | 75
decreased hemoglobin content 10 | 53
decreased leukocyte cell numbe... 10 | 54
decreased lumbar vertebrae num... 10 | 62
increased circulating HDL chol... 10 | 63
increased circulating calcium ... 10 | 32
increased circulating chloride... 10 | 43
increased total body fat amoun... 10 | 57
abnormal heart morphology 9 | 51
decreased circulating free fat... 9 | 39
decreased erythrocyte cell num... 9 | 43
increased blood urea nitrogen ... 9 | 44
increased circulating phosphat... 9 | 24
increased startle reflex 9 | 38
limb grasping 9 | 35
tremors 9 | 34
decreased rib number 8 | 59
decreased startle reflex 8 | 48
enlarged lymph nodes 8 | 27
increased body weight 8 | 42
increased circulating choleste... 8 | 53
increased circulating triglyce... 8 | 24
prenatal lethality prior to he... 8 | 64
thrombocytosis 8 | 23
abnormal cranium morphology 7 | 32
abnormal neural tube closure 7 | 37
abnormal retinal pigmentation 7 | 61
decreased circulating amylase ... 7 | 24
decreased circulating aspartat... 7 | 27
decreased fasted circulating g... 7 | 49
decreased heart weight 7 | 44
female infertility 7 | 34
increased circulating potassiu... 7 | 31
increased hemoglobin content 7 | 45
increased leukocyte cell numbe... 7 | 37
abnormal cornea morphology 6 | 24
abnormal epididymis morphology 6 | 31
abnormal tooth morphology 6 | 24
decreased B cell number 6 | 30
decreased circulating fructosa... 6 | 31
decreased circulating total pr... 6 | 41
enlarged spleen 6 | 26
increased CD4-positive, CD25-p... 6 | 18
increased circulating serum al... 6 | 25
increased exploration in new e... 6 | 56
increased fasted circulating g... 6 | 68
persistence of hyaloid vascula... 6 | 22
thrombocytopenia 6 | 46
vertebral fusion 6 | 23
vertebral transformation 6 | 12
decreased NK T cell number 5 | 28
decreased caudal vertebrae num... 5 | 49
decreased circulating glycerol... 5 | 19
impaired glucose tolerance 5 | 52
increased circulating iron lev... 5 | 25
increased circulating total pr... 5 | 20
increased heart weight 5 | 37

Disease

ependymoma 2,514 | 2,514
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 2,498 | 18,561
Digestive Tract 2,496 | 18,473
Female tissues 2,495 | 18,647
Urinary Tract 2,493 | 18,444
Liver and Pancreas 2,492 | 18,136
Male tissues 2,489 | 17,969
Cardiovascular System 2,487 | 17,958
Endocrine System 2,487 | 18,512
Blood and immune system 2,484 | 17,995
Skin and soft tissues 2,478 | 18,115
Respiratory system 2,471 | 17,484

Target Family

Non-IDG 1,454 | 11,971
Enzyme 529 | 4,146
Transcription Factor 154 | 1,400
Kinase 124 | 634
Transporter 82 | 473
Ion Channel 62 | 341
GPCR 49 | 406
Epigenetic 42 | 242
TF/Epigenetic 9 | 38
Nuclear Receptor 7 | 48
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Transmembrane protein 229B TMEM229B Tdark Non-IDG 1.34 0.03 3
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269