Development Level

Tbio 3,072 | 11,445
Tdark 970 | 6,588
Tchem 447 | 1,598
Tclin 190 | 613

Collection

RFA-RM-18-021 96 | 328
Kinase: IDG Consortium (Target... 41 | 125
Ion Channel: IDG Consortium (T... 38 | 99
GPCR: IDG Consortium (Targets) 19 | 126
Kinase: IDG Consortium (Comple... 16 | 37
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 232 | 979
preweaning lethality, incomple... 161 | 499
abnormal behavior 111 | 298
decreased total body fat amoun... 80 | 207
embryonic lethality prior to t... 68 | 278
abnormal embryo size 61 | 220
increased lean body mass 61 | 172
abnormal bone structure 58 | 187
hyperactivity 58 | 148
decreased bone mineral content 52 | 151
decreased vertical activity 51 | 208
hypoactivity 50 | 132
decreased body weight 48 | 161
decreased lean body mass 48 | 135
increased total body fat amoun... 47 | 134
increased bone mineral content 45 | 108
enlarged heart 44 | 210
increased circulating alkaline... 43 | 122
embryonic lethality prior to o... 42 | 239
decreased grip strength 39 | 116
increased startle reflex 39 | 112
male infertility 38 | 123
decreased bone mineral density 36 | 126
decreased circulating choleste... 34 | 93
abnormal heart morphology 33 | 162
short tibia 32 | 97
decreased circulating glucose ... 31 | 126
increased or absent threshold ... 31 | 101
decreased body length 30 | 101
decreased circulating serum al... 29 | 82
decreased lymphocyte cell numb... 29 | 83
decreased prepulse inhibition 29 | 82
embryonic growth retardation 29 | 106
abnormal seminal vesicle morph... 28 | 114
increased mean corpuscular vol... 27 | 92
cataract 26 | 92
decreased startle reflex 26 | 75
abnormal gait 25 | 69
abnormal lens morphology 25 | 81
abnormal sleep behavior 24 | 70
decreased circulating HDL chol... 24 | 68
decreased fasted circulating g... 24 | 65
increased bone mineral density 24 | 72
increased circulating HDL chol... 24 | 80
increased mean corpuscular hem... 24 | 96
decreased circulating triglyce... 23 | 79
decreased hemoglobin content 23 | 68
abnormal coat-hair pigmentatio... 22 | 64
decreased circulating insulin ... 22 | 76
improved glucose tolerance 22 | 79
increased heart weight 22 | 62
abnormal eye morphology 21 | 68
decreased erythrocyte cell num... 21 | 62
decreased mean corpuscular vol... 20 | 79
increased circulating choleste... 20 | 66
increased circulating triglyce... 20 | 42
increased monocyte cell number 20 | 63
decreased leukocyte cell numbe... 19 | 73
increased blood urea nitrogen ... 19 | 48
decreased circulating LDL chol... 18 | 38
edema 18 | 59
female infertility 18 | 60
increased circulating chloride... 18 | 41
limb grasping 18 | 41
small testis 18 | 58
abnormal behavioral response t... 17 | 66
abnormal kidney morphology 17 | 65
increased circulating calcium ... 17 | 34
increased circulating sodium l... 17 | 71
increased leukocyte cell numbe... 17 | 47
small superior vagus ganglion 17 | 74
abnormal epididymis morphology 16 | 42
abnormal retina morphology 16 | 71
decreased circulating calcium ... 16 | 36
impaired glucose tolerance 16 | 75
prenatal lethality prior to he... 16 | 87
decreased hematocrit 15 | 46
decreased neutrophil cell numb... 15 | 42
increased fasted circulating g... 15 | 76
increased mean platelet volume 15 | 45
increased neutrophil cell numb... 15 | 46
abnormal cranium morphology 14 | 36
abnormal skin morphology 14 | 50
abnormal tooth morphology 14 | 24
decreased blood urea nitrogen ... 14 | 51
decreased caudal vertebrae num... 14 | 53
decreased circulating alkaline... 14 | 46
decreased circulating total pr... 14 | 49
decreased mean corpuscular hem... 14 | 50
increased circulating creatini... 14 | 38
persistence of hyaloid vascula... 14 | 33
tremors 14 | 39
abnormal locomotor behavior 13 | 24
decreased circulating alanine ... 13 | 47
decreased mean corpuscular hem... 13 | 31
increased circulating iron lev... 13 | 30
increased circulating potassiu... 13 | 29
increased hematocrit 13 | 46
increased mean corpuscular hem... 13 | 36
thrombocytopenia 13 | 56

Disease

ependymoma 4,679 | 4,679
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 4,629 | 18,159
Nervous System 4,619 | 16,725
Female tissues 4,575 | 17,400
Digestive Tract 4,569 | 17,369
Skin and soft tissues 4,558 | 17,230
Male tissues 4,544 | 17,142
Liver and Pancreas 4,483 | 16,750
Urinary Tract 4,478 | 16,678
Blood and immune system 4,462 | 16,909
Respiratory system 4,435 | 16,393
Cardiovascular System 4,195 | 15,192

Target Family

Non-IDG 2,796 | 12,091
Enzyme 961 | 4,145
Transcription Factor 282 | 1,400
Kinase 210 | 634
Transporter 133 | 473
Ion Channel 123 | 344
GPCR 91 | 408
Epigenetic 58 | 242
TF/Epigenetic 13 | 38
Nuclear Receptor 10 | 48
oGPCR 2 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
Hexosaminidase D HEXDC Tbio Enzyme -0.60206 3.83 63
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Zinc finger protein 160 ZNF160 Tdark Transcription Factor -0.67261 4.33 63
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127