Development Level

Tbio 1,149 | 10,625
Tdark 273 | 7,003
Tchem 251 | 1,890
Tclin 72 | 602

Collection

Eligible non-olfactory GPCR Proteins 10 | 143
Eligible Ion Channel Proteins 8 | 117
Eligible Kinase Proteins 5 | 134

IMPC Term

preweaning lethality, complete... 67 | 633
preweaning lethality, incomple... 34 | 260
decreased total body fat amoun... 24 | 186
abnormal behavior 22 | 226
decreased lean body mass 20 | 195
abnormal bone structure 19 | 131
decreased body weight 19 | 174
decreased bone mineral content 18 | 157
increased or absent threshold ... 18 | 128
abnormal embryo size 16 | 112
increased circulating alkaline... 16 | 119
increased mean corpuscular vol... 16 | 91
decreased bone mineral density 15 | 126
embryonic lethality prior to t... 15 | 187
abnormal retina morphology 14 | 100
increased lean body mass 14 | 107
decreased prepulse inhibition 13 | 52
decreased body length 12 | 108
decreased circulating HDL chol... 12 | 77
hypoactivity 12 | 89
increased mean corpuscular hem... 12 | 93
decreased circulating choleste... 11 | 85
decreased circulating glucose ... 10 | 121
decreased circulating triglyce... 10 | 83
decreased hemoglobin content 10 | 53
decreased startle reflex 10 | 48
enlarged heart 10 | 111
impaired glucose tolerance 10 | 52
abnormal retinal pigmentation 9 | 61
decreased grip strength 9 | 123
increased bone mineral content 9 | 92
increased hematocrit 9 | 36
increased hemoglobin content 9 | 45
abnormal bone mineralization 8 | 55
abnormal gait 8 | 51
abnormal spleen morphology 8 | 36
decreased circulating insulin ... 8 | 75
decreased circulating total pr... 8 | 41
decreased leukocyte cell numbe... 8 | 54
decreased mean corpuscular vol... 8 | 50
embryonic lethality prior to o... 8 | 148
increased total body fat amoun... 8 | 57
abnormal QRS complex 7 | 25
abnormal lens morphology 7 | 73
decreased T cell number 7 | 31
decreased circulating LDL chol... 7 | 37
decreased circulating alkaline... 7 | 41
decreased circulating serum al... 7 | 79
decreased eosinophil cell numb... 7 | 41
decreased erythrocyte cell num... 7 | 43
decreased fasted circulating g... 7 | 49
decreased heart weight 7 | 44
hyperactivity 7 | 108
increased blood urea nitrogen ... 7 | 44
increased circulating calcium ... 7 | 32
increased circulating choleste... 7 | 53
increased grip strength 7 | 83
increased heart weight 7 | 37
increased rib number 7 | 41
short tibia 7 | 82
thrombocytopenia 7 | 46
abnormal behavioral response t... 6 | 52
abnormal cranium morphology 6 | 32
abnormal locomotor activation 6 | 26
abnormal neural tube closure 6 | 37
abnormal sleep behavior 6 | 63
cardiovascular system phenotyp... 6 | 35
corneal opacity 6 | 25
decreased CD8-positive, alpha-... 6 | 26
decreased caudal vertebrae num... 6 | 49
decreased circulating calcium ... 6 | 33
decreased rib number 6 | 59
improved glucose tolerance 6 | 56
increased bone mineral density 6 | 52
increased circulating HDL chol... 6 | 63
increased circulating iron lev... 6 | 25
increased exploration in new e... 6 | 56
increased fasted circulating g... 6 | 68
limb grasping 6 | 35
male infertility 6 | 62
prenatal lethality prior to he... 6 | 64
abnormal coat/hair pigmentatio... 5 | 54
abnormal eye morphology 5 | 38
abnormal heart morphology 5 | 51
abnormal startle reflex 5 | 14
decreased CD4-positive, alpha ... 5 | 19
decreased circulating alanine ... 5 | 53
decreased hematocrit 5 | 25
decreased mean corpuscular hem... 5 | 34
embryonic growth retardation 5 | 28
increased circulating potassiu... 5 | 31
increased circulating triglyce... 5 | 24
tremors 5 | 34
abnormal heart left ventricle ... 4 | 20
decreased circulating free fat... 4 | 39
decreased circulating glycerol... 4 | 19
increased body weight 4 | 42
increased circulating chloride... 4 | 43
increased circulating sodium l... 4 | 71
increased circulating total pr... 4 | 20

Disease

ductal carcinoma in situ 1,745 | 1,745
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 1,733 | 18,647
Nervous System 1,733 | 18,561
Digestive Tract 1,732 | 18,473
Liver and Pancreas 1,731 | 18,136
Urinary Tract 1,731 | 18,444
Endocrine System 1,729 | 18,512
Cardiovascular System 1,728 | 17,958
Male tissues 1,728 | 17,969
Respiratory system 1,727 | 17,484
Blood and immune system 1,726 | 17,995
Skin and soft tissues 1,720 | 18,115

Target Family

Non-IDG 1,028 | 11,971
Enzyme 376 | 4,146
Transcription Factor 118 | 1,400
Kinase 73 | 634
Transporter 54 | 473
GPCR 43 | 406
Ion Channel 22 | 341
Epigenetic 16 | 242
Nuclear Receptor 12 | 48
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Equilibrative nucleoside transporter 4 SLC29A4 Tbio Transporter -1.79381 73.1 189
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277