Development Level

Tbio 1,252 | 11,651
Tdark 229 | 6,593
Tchem 189 | 1,388
Tclin 75 | 612

Collection

RFA-RM-18-021 22 | 328
GPCR: IDG Consortium (Targets) 9 | 126
Ion Channel: IDG Consortium (T... 7 | 99
Kinase: IDG Consortium (Target... 5 | 125
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 83 | 979
preweaning lethality, incomple... 62 | 499
decreased total body fat amoun... 29 | 207
abnormal behavior 28 | 298
abnormal embryo size 28 | 220
enlarged heart 27 | 210
embryonic lethality prior to t... 26 | 278
abnormal bone structure 25 | 187
decreased vertical activity 25 | 208
abnormal heart morphology 24 | 162
decreased body weight 22 | 161
increased lean body mass 21 | 172
hypoactivity 20 | 132
decreased prepulse inhibition 18 | 82
embryonic lethality prior to o... 17 | 239
decreased bone mineral content 15 | 151
increased total body fat amoun... 15 | 134
abnormal seminal vesicle morph... 14 | 114
decreased startle reflex 14 | 75
decreased circulating choleste... 13 | 93
increased circulating HDL chol... 13 | 80
increased circulating alkaline... 13 | 122
increased mean corpuscular vol... 13 | 92
cataract 12 | 92
decreased grip strength 12 | 116
hyperactivity 12 | 148
increased bone mineral content 12 | 108
increased heart weight 12 | 62
prenatal lethality prior to he... 12 | 87
abnormal eye morphology 11 | 68
decreased bone mineral density 11 | 126
decreased circulating HDL chol... 11 | 68
decreased lean body mass 11 | 135
embryonic growth retardation 11 | 106
increased circulating choleste... 11 | 66
increased or absent threshold ... 11 | 101
abnormal gait 10 | 69
increased startle reflex 10 | 112
abnormal behavioral response t... 9 | 66
abnormal kidney morphology 9 | 65
abnormal lens morphology 9 | 81
abnormal sleep behavior 9 | 70
decreased body length 9 | 101
decreased circulating triglyce... 9 | 79
decreased fasted circulating g... 9 | 65
decreased hemoglobin content 9 | 68
decreased leukocyte cell numbe... 9 | 73
impaired glucose tolerance 9 | 75
increased bone mineral density 9 | 72
increased mean corpuscular hem... 9 | 96
male infertility 9 | 123
abnormal retina morphology 8 | 71
abnormal spleen morphology 8 | 55
decreased circulating glucose ... 8 | 126
decreased lymphocyte cell numb... 8 | 83
decreased mean corpuscular vol... 8 | 79
edema 8 | 59
increased hematocrit 8 | 46
increased hemoglobin content 8 | 45
short tibia 8 | 97
thrombocytopenia 8 | 56
abnormal cranium morphology 7 | 36
abnormal tail morphology 7 | 25
decreased circulating LDL chol... 7 | 38
decreased circulating insulin ... 7 | 76
decreased circulating total pr... 7 | 49
improved glucose tolerance 7 | 79
increased circulating triglyce... 7 | 42
increased fasted circulating g... 7 | 76
increased neutrophil cell numb... 7 | 46
limb grasping 7 | 41
abnormal coat-hair pigmentatio... 6 | 64
abnormal craniofacial morpholo... 6 | 33
abnormal neural tube closure 6 | 46
corneal opacity 6 | 32
decreased caudal vertebrae num... 6 | 53
decreased circulating alkaline... 6 | 46
decreased circulating calcium ... 6 | 36
enlarged lymph nodes 6 | 37
female infertility 6 | 60
increased circulating calcium ... 6 | 34
increased circulating glucose ... 6 | 24
prolonged QT interval 6 | 38
tremors 6 | 39
abnormal bone mineralization 5 | 38
abnormal cornea morphology 5 | 31
abnormal skin morphology 5 | 50
abnormal testis morphology 5 | 43
cardiovascular system phenotyp... 5 | 36
decreased T cell number 5 | 15
decreased circulating creatini... 5 | 39
decreased circulating serum al... 5 | 82
decreased hematocrit 5 | 46
hydrometra 5 | 53
increased circulating iron lev... 5 | 30
increased monocyte cell number 5 | 63
microphthalmia 5 | 26
pallor 5 | 34
prolonged ST segment 5 | 36
small testis 5 | 58

Disease

ductal carcinoma in situ 1,745 | 1,745
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Female tissues 1,732 | 17,400
Endocrine System 1,731 | 18,159
Digestive Tract 1,730 | 17,369
Skin and soft tissues 1,729 | 17,230
Male tissues 1,724 | 17,142
Blood and immune system 1,723 | 16,909
Liver and Pancreas 1,722 | 16,750
Urinary Tract 1,720 | 16,678
Respiratory system 1,715 | 16,393
Nervous System 1,702 | 16,725
Cardiovascular System 1,666 | 15,192

Target Family

Non-IDG 1,027 | 12,091
Enzyme 376 | 4,145
Transcription Factor 118 | 1,400
Kinase 74 | 634
Transporter 54 | 473
GPCR 43 | 408
Ion Channel 22 | 344
Epigenetic 16 | 242
Nuclear Receptor 12 | 48
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Eukaryotic translation initiation factor 1 EIF1 Tbio Non-IDG -2.06392 118.5 92
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
UPF0577 protein KIAA1324 KIAA1324 Tbio Non-IDG -1.30268 19.8 137
CMRF35-like molecule 9 CD300LG Tdark Non-IDG -0.92828 10.3 49
Butyrophilin-like protein 9 BTNL9 Tdark Non-IDG -0.69979 4.69 67
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
Lamina-associated polypeptide 2, isoform alpha TMPO Tbio Non-IDG -2.11834 246.0 283
Macrophage receptor MARCO MARCO Tbio Non-IDG -2.37206 210.3 189