Development Level

Tbio 1,038 | 11,445
Tdark 307 | 6,588
Tchem 279 | 1,598
Tclin 104 | 613

Collection

RFA-RM-18-021 19 | 328
GPCR: IDG Consortium (Targets) 11 | 126
Kinase: IDG Consortium (Target... 11 | 125
GPCR: IDG Consortium (Complete... 4 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 100 | 979
preweaning lethality, incomple... 42 | 499
embryonic lethality prior to t... 35 | 278
embryonic lethality prior to o... 29 | 239
decreased vertical activity 25 | 208
enlarged heart 22 | 210
abnormal embryo size 18 | 220
hypoactivity 18 | 132
increased total body fat amoun... 18 | 134
abnormal behavior 17 | 298
decreased total body fat amoun... 17 | 207
abnormal heart morphology 16 | 162
decreased body weight 16 | 161
abnormal seminal vesicle morph... 15 | 114
decreased bone mineral content 15 | 151
cataract 14 | 92
increased circulating choleste... 14 | 66
abnormal bone structure 13 | 187
increased lean body mass 13 | 172
increased startle reflex 13 | 112
decreased lean body mass 12 | 135
abnormal gait 11 | 69
abnormal lens morphology 11 | 81
decreased leukocyte cell numbe... 11 | 73
hyperactivity 11 | 148
increased circulating alkaline... 11 | 122
abnormal retina morphology 10 | 71
decreased bone mineral density 10 | 126
impaired glucose tolerance 10 | 75
improved glucose tolerance 10 | 79
increased bone mineral content 10 | 108
increased circulating HDL chol... 10 | 80
increased mean corpuscular vol... 10 | 92
decreased circulating glucose ... 9 | 126
decreased circulating triglyce... 9 | 79
decreased lymphocyte cell numb... 9 | 83
embryonic growth retardation 9 | 106
increased fasted circulating g... 9 | 76
prolonged ST segment 9 | 36
short tibia 9 | 97
thrombocytopenia 9 | 56
decreased body length 8 | 101
decreased circulating choleste... 8 | 93
decreased fasted circulating g... 8 | 65
decreased grip strength 8 | 116
increased hemoglobin content 8 | 45
increased mean corpuscular hem... 8 | 96
increased mean corpuscular hem... 8 | 36
prolonged QT interval 8 | 38
abnormal sleep behavior 7 | 70
decreased circulating HDL chol... 7 | 68
decreased circulating alanine ... 7 | 47
decreased circulating aspartat... 7 | 34
decreased circulating insulin ... 7 | 76
increased circulating sodium l... 7 | 71
increased heart weight 7 | 62
increased monocyte cell number 7 | 63
increased or absent threshold ... 7 | 101
small superior vagus ganglion 7 | 74
decreased circulating LDL chol... 6 | 38
decreased circulating serum al... 6 | 82
decreased mean corpuscular vol... 6 | 79
increased circulating serum al... 6 | 22
increased grip strength 6 | 41
increased leukocyte cell numbe... 6 | 47
prenatal lethality prior to he... 6 | 87
small testis 6 | 58
abnormal bone mineralization 5 | 38
abnormal kidney morphology 5 | 65
abnormal neural tube closure 5 | 46
abnormal skin morphology 5 | 50
abnormal testis morphology 5 | 43
decreased blood urea nitrogen ... 5 | 51
decreased erythrocyte cell num... 5 | 62
decreased neutrophil cell numb... 5 | 42
decreased startle reflex 5 | 75
hydrometra 5 | 53
increased bone mineral density 5 | 72
increased circulating iron lev... 5 | 30
increased circulating total pr... 5 | 28
increased circulating triglyce... 5 | 42
increased heart rate 5 | 23
increased lymphocyte cell numb... 5 | 32
increased mean platelet volume 5 | 45
increased neutrophil cell numb... 5 | 46
pale yolk sac 5 | 25
abnormal eye morphology 4 | 68
abnormal spleen morphology 4 | 55
cardiovascular system phenotyp... 4 | 36
decreased circulating alkaline... 4 | 46
decreased circulating creatini... 4 | 39
decreased hemoglobin content 4 | 68
decreased lactate dehydrogenas... 4 | 16
decreased prepulse inhibition 4 | 82
increased body weight 4 | 25
increased circulating aspartat... 4 | 15
increased circulating bilirubi... 4 | 16
increased circulating free fat... 4 | 20
increased hematocrit 4 | 46
pallor 4 | 34

Disease

diabetes mellitus 1,728 | 1,728
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 1,507 | 18,159
Digestive Tract 1,467 | 17,369
Female tissues 1,461 | 17,400
Skin and soft tissues 1,443 | 17,230
Blood and immune system 1,426 | 16,909
Male tissues 1,417 | 17,142
Liver and Pancreas 1,408 | 16,750
Urinary Tract 1,394 | 16,678
Nervous System 1,387 | 16,725
Respiratory system 1,364 | 16,393
Cardiovascular System 1,288 | 15,192

Target Family

Non-IDG 987 | 12,091
Enzyme 385 | 4,145
Transcription Factor 83 | 1,400
oGPCR 71 | 421
Kinase 66 | 634
GPCR 46 | 408
Transporter 41 | 473
Epigenetic 19 | 242
Ion Channel 13 | 344
Nuclear Receptor 12 | 48
TF/Epigenetic 5 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
Keratin-associated protein 9-1 KRTAP9-1 Tdark Non-IDG 0.00000 0
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ST6GALNAC2 Tbio Enzyme -1.74190 55.6 59
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Protein NipSnap homolog 3B NIPSNAP3B Tbio Non-IDG -1.06487 11.0 103