Development Level

Tbio 975 | 11,178
Tchem 305 | 1,885
Tdark 303 | 6,569
Tclin 100 | 612

Collection

GPCR: IDG Consortium (Targets) 11 | 126
Kinase: IDG Consortium (Target... 10 | 125
GPCR: IDG Consortium (Complete... 4 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 94 | 979
preweaning lethality, incomple... 40 | 499
embryonic lethality prior to t... 33 | 278
embryonic lethality prior to o... 28 | 239
decreased vertical activity 24 | 208
enlarged heart 21 | 210
abnormal behavior 17 | 298
hypoactivity 17 | 132
increased total body fat amoun... 17 | 134
abnormal embryo size 16 | 220
abnormal heart morphology 16 | 162
decreased body weight 16 | 161
decreased total body fat amoun... 16 | 207
abnormal seminal vesicle morph... 14 | 114
cataract 14 | 92
decreased bone mineral content 14 | 151
increased circulating choleste... 14 | 66
abnormal bone structure 13 | 187
increased startle reflex 13 | 112
increased lean body mass 12 | 172
abnormal lens morphology 11 | 81
decreased lean body mass 11 | 135
hyperactivity 11 | 148
abnormal gait 10 | 69
abnormal retina morphology 10 | 71
decreased bone mineral density 10 | 126
decreased leukocyte cell numbe... 10 | 73
impaired glucose tolerance 10 | 75
improved glucose tolerance 10 | 79
increased circulating HDL chol... 10 | 80
increased circulating alkaline... 10 | 122
decreased circulating glucose ... 9 | 126
decreased circulating triglyce... 9 | 79
decreased lymphocyte cell numb... 9 | 83
increased bone mineral content 9 | 108
increased mean corpuscular vol... 9 | 92
thrombocytopenia 9 | 56
decreased body length 8 | 101
decreased grip strength 8 | 116
embryonic growth retardation 8 | 106
increased fasted circulating g... 8 | 76
increased hemoglobin content 8 | 45
increased mean corpuscular hem... 8 | 36
prolonged QT interval 8 | 38
abnormal sleep behavior 7 | 70
decreased circulating alanine ... 7 | 47
decreased circulating insulin ... 7 | 76
decreased fasted circulating g... 7 | 65
increased circulating sodium l... 7 | 71
increased heart weight 7 | 62
increased mean corpuscular hem... 7 | 96
increased monocyte cell number 7 | 63
prolonged ST segment 7 | 36
small superior vagus ganglion 7 | 74
decreased circulating LDL chol... 6 | 38
decreased circulating aspartat... 6 | 34
decreased circulating choleste... 6 | 93
decreased circulating serum al... 6 | 82
decreased mean corpuscular vol... 6 | 79
increased circulating serum al... 6 | 22
increased grip strength 6 | 41
increased leukocyte cell numbe... 6 | 47
increased or absent threshold ... 6 | 101
short tibia 6 | 97
small testis 6 | 58
abnormal bone mineralization 5 | 38
abnormal kidney morphology 5 | 65
abnormal neural tube closure 5 | 46
abnormal skin morphology 5 | 50
abnormal testis morphology 5 | 43
decreased blood urea nitrogen ... 5 | 51
decreased circulating HDL chol... 5 | 68
decreased erythrocyte cell num... 5 | 62
decreased neutrophil cell numb... 5 | 42
decreased startle reflex 5 | 75
hydrometra 5 | 53
increased circulating iron lev... 5 | 30
increased circulating total pr... 5 | 28
increased circulating triglyce... 5 | 42
increased heart rate 5 | 23
increased lymphocyte cell numb... 5 | 32
increased mean platelet volume 5 | 45
increased neutrophil cell numb... 5 | 46
pale yolk sac 5 | 25
prenatal lethality prior to he... 5 | 87
abnormal eye morphology 4 | 68
abnormal spleen morphology 4 | 55
cardiovascular system phenotyp... 4 | 36
decreased caudal vertebrae num... 4 | 53
decreased circulating alkaline... 4 | 46
decreased circulating creatini... 4 | 39
decreased hemoglobin content 4 | 68
decreased lactate dehydrogenas... 4 | 16
increased body weight 4 | 25
increased circulating aspartat... 4 | 15
increased circulating bilirubi... 4 | 16
increased circulating free fat... 4 | 20
increased hematocrit 4 | 46
pallor 4 | 34
tremors 4 | 39

Disease

diabetes mellitus 1,683 | 1,683
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
acute myeloid leukemia 760 | 760
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Endocrine System 1,462 | 18,159
Digestive Tract 1,423 | 17,369
Female tissues 1,416 | 17,400
Skin and soft tissues 1,398 | 17,230
Blood and immune system 1,383 | 16,909
Male tissues 1,372 | 17,142
Liver and Pancreas 1,365 | 16,750
Urinary Tract 1,350 | 16,678
Nervous System 1,342 | 16,725
Respiratory system 1,323 | 16,393
Cardiovascular System 1,248 | 15,192

Target Family

Non-IDG 978 | 12,091
Enzyme 354 | 4,145
Transcription Factor 79 | 1,400
oGPCR 71 | 421
Kinase 65 | 634
GPCR 46 | 408
Transporter 41 | 473
Epigenetic 19 | 242
Ion Channel 13 | 344
Nuclear Receptor 12 | 48
TF/Epigenetic 5 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Interleukin-4 IL4 Tbio Non-IDG -3.98318 9219.0 1325
Nidogen-2 NID2 Tbio Non-IDG -1.62355 40.1 116
Taste receptor type 1 member 2 TAS1R2 Tchem GPCR -2.03403 100.4 150
Keratin-associated protein 5-4 KRTAP5-4 Tdark Non-IDG -0.33579 2.15 0
Keratin-associated protein 5-3 KRTAP5-3 Tdark Non-IDG 0.00000 0
T-lymphocyte activation antigen CD80 CD80 Tclin Non-IDG -3.39216 2405.6 1323
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
HLA class I histocompatibility antigen, B-67 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 362
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417