Development Level

Tbio 932 | 10,625
Tdark 324 | 7,003
Tchem 314 | 1,890
Tclin 93 | 602

Collection

Eligible non-olfactory GPCR Proteins 12 | 143
Eligible Kinase Proteins 11 | 134

IMPC Term

preweaning lethality, complete... 66 | 633
embryonic lethality prior to t... 23 | 187
embryonic lethality prior to o... 22 | 148
preweaning lethality, incomple... 20 | 260
decreased lean body mass 18 | 195
abnormal behavior 17 | 226
decreased body weight 17 | 174
decreased total body fat amoun... 17 | 186
decreased grip strength 15 | 123
increased circulating alkaline... 13 | 119
increased or absent threshold ... 13 | 128
abnormal retina morphology 12 | 100
decreased body length 11 | 108
decreased bone mineral density 11 | 126
enlarged heart 10 | 111
hyperactivity 10 | 108
hypoactivity 10 | 89
increased circulating choleste... 10 | 53
short tibia 10 | 82
abnormal embryo size 9 | 112
decreased circulating triglyce... 9 | 83
increased mean corpuscular vol... 9 | 91
abnormal bone mineralization 8 | 55
abnormal gait 8 | 51
decreased bone mineral content 8 | 157
decreased leukocyte cell numbe... 8 | 54
impaired glucose tolerance 8 | 52
improved glucose tolerance 8 | 56
increased bone mineral content 8 | 92
increased circulating HDL chol... 8 | 63
increased grip strength 8 | 83
increased hemoglobin content 8 | 45
increased mean corpuscular hem... 8 | 93
abnormal lens morphology 7 | 73
decreased circulating HDL chol... 7 | 77
decreased circulating alanine ... 7 | 53
decreased circulating insulin ... 7 | 75
decreased rib number 7 | 59
increased bone mineral density 7 | 52
increased lean body mass 7 | 107
increased mean corpuscular hem... 7 | 25
increased total body fat amoun... 7 | 57
thrombocytopenia 7 | 46
abnormal heart morphology 6 | 51
abnormal seminal vesicle morph... 6 | 47
abnormal tooth morphology 6 | 24
decreased circulating LDL chol... 6 | 37
decreased circulating aspartat... 6 | 27
decreased circulating choleste... 6 | 85
increased body weight 6 | 42
increased circulating sodium l... 6 | 71
increased startle reflex 6 | 38
prenatal lethality prior to he... 6 | 64
abnormal bone structure 5 | 131
abnormal sleep behavior 5 | 63
decreased circulating chloride... 5 | 32
decreased circulating glucose ... 5 | 121
decreased fasted circulating g... 5 | 49
decreased heart weight 5 | 44
decreased lumbar vertebrae num... 5 | 62
decreased prepulse inhibition 5 | 52
decreased threshold for audito... 5 | 32
increased circulating phosphat... 5 | 24
increased circulating total pr... 5 | 20
increased fasted circulating g... 5 | 68
increased hematocrit 5 | 36
increased sacral vertebrae num... 5 | 62
abnormal kidney morphology 4 | 30
abnormal testis morphology 4 | 30
cataract 4 | 26
decreased B cell number 4 | 30
decreased caudal vertebrae num... 4 | 49
decreased circulating alkaline... 4 | 41
decreased circulating calcium ... 4 | 33
decreased circulating creatini... 4 | 31
decreased circulating phosphat... 4 | 15
decreased circulating serum al... 4 | 79
decreased mean corpuscular hem... 4 | 19
decreased mean corpuscular vol... 4 | 50
enlarged epididymis 4 | 27
increased circulating aspartat... 4 | 17
increased circulating creatini... 4 | 29
increased circulating free fat... 4 | 17
increased circulating serum al... 4 | 25
increased circulating triglyce... 4 | 24
increased exploration in new e... 4 | 56
small testis 4 | 37
abnormal coat/hair pigmentatio... 3 | 54
abnormal cranium morphology 3 | 32
cardiovascular system phenotyp... 3 | 35
decreased NK T cell number 3 | 28
decreased blood urea nitrogen ... 3 | 31
decreased circulating iron lev... 3 | 25
increased circulating calcium ... 3 | 32
increased circulating potassiu... 3 | 31
increased heart weight 3 | 37
increased respiratory quotient 3 | 12
increased rib number 3 | 41
long tibia 3 | 13
thrombocytosis 3 | 23

Disease

diabetes mellitus 1,663 | 1,663
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 1,541 | 18,647
Nervous System 1,534 | 18,561
Endocrine System 1,518 | 18,512
Digestive Tract 1,515 | 18,473
Urinary Tract 1,515 | 18,444
Skin and soft tissues 1,489 | 18,115
Liver and Pancreas 1,479 | 18,136
Blood and immune system 1,458 | 17,995
Cardiovascular System 1,450 | 17,958
Male tissues 1,431 | 17,969
Respiratory system 1,409 | 17,484

Target Family

Non-IDG 961 | 11,971
Enzyme 363 | 4,146
Transcription Factor 75 | 1,400
oGPCR 71 | 421
Kinase 62 | 634
GPCR 44 | 406
Transporter 40 | 473
Epigenetic 20 | 242
Ion Channel 12 | 341
Nuclear Receptor 10 | 48
TF/Epigenetic 5 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165