Development Level

Tbio 655 | 10,625
Tchem 155 | 1,890
Tdark 93 | 7,003
Tclin 30 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 56 | 633
embryonic lethality prior to t... 19 | 187
preweaning lethality, incomple... 17 | 260
abnormal behavior 14 | 226
decreased body weight 14 | 174
decreased lean body mass 14 | 195
decreased total body fat amoun... 13 | 186
embryonic lethality prior to o... 13 | 148
abnormal embryo size 11 | 112
increased mean corpuscular hem... 10 | 93
decreased body length 9 | 108
decreased bone mineral content 9 | 157
increased circulating HDL chol... 9 | 63
increased circulating alkaline... 9 | 119
abnormal retina morphology 8 | 100
decreased grip strength 8 | 123
decreased prepulse inhibition 8 | 52
increased mean corpuscular vol... 8 | 91
short tibia 8 | 82
decreased bone mineral density 7 | 126
increased circulating choleste... 7 | 53
decreased caudal vertebrae num... 6 | 49
decreased circulating triglyce... 6 | 83
hyperactivity 6 | 108
hypoactivity 6 | 89
increased bone mineral content 6 | 92
increased fasted circulating g... 6 | 68
abnormal bone mineralization 5 | 55
abnormal lens morphology 5 | 73
decreased mean corpuscular vol... 5 | 50
increased blood urea nitrogen ... 5 | 44
increased lean body mass 5 | 107
increased or absent threshold ... 5 | 128
prenatal lethality prior to he... 5 | 64
abnormal bone structure 4 | 131
abnormal coat/hair pigmentatio... 4 | 54
abnormal neural tube closure 4 | 37
decreased CD4-positive, CD25-p... 4 | 24
decreased circulating glucose ... 4 | 121
decreased leukocyte cell numbe... 4 | 54
decreased mean corpuscular hem... 4 | 34
increased circulating iron lev... 4 | 25
increased circulating sodium l... 4 | 71
increased grip strength 4 | 83
abnormal cranium morphology 3 | 32
abnormal retinal pigmentation 3 | 61
decreased NK T cell number 3 | 28
decreased circulating creatini... 3 | 31
decreased circulating insulin ... 3 | 75
decreased circulating iron lev... 3 | 25
decreased erythrocyte cell num... 3 | 43
decreased hemoglobin content 3 | 53
decreased lumbar vertebrae num... 3 | 62
decreased monocyte cell number 3 | 28
hydrops fetalis 3 | 22
improved glucose tolerance 3 | 56
increased circulating glycerol... 3 | 11
increased erythrocyte cell num... 3 | 26
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
increased rib number 3 | 41
increased startle reflex 3 | 38
male infertility 3 | 62
thrombocytopenia 3 | 46
abnormal QRS complex 2 | 25
abnormal behavioral response t... 2 | 52
abnormal coping response 2 | 12
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
abnormal thoracic vertebrae mo... 2 | 16
absent startle reflex 2 | 15
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
decreased CD8-positive, alpha-... 2 | 26
decreased T cell number 2 | 31
decreased circulating HDL chol... 2 | 77
decreased circulating chloride... 2 | 32
decreased effector memory CD8-... 2 | 24
decreased mean corpuscular hem... 2 | 19
decreased neutrophil cell numb... 2 | 37
decreased rib number 2 | 59
decreased startle reflex 2 | 48
decreased threshold for audito... 2 | 32
embryonic growth retardation 2 | 28
enlarged lymph nodes 2 | 27
impaired glucose tolerance 2 | 52
increased B cell number 2 | 23
increased bone mineral density 2 | 52
increased circulating calcium ... 2 | 32
increased circulating glucose ... 2 | 16
increased circulating potassiu... 2 | 31
increased circulating triglyce... 2 | 24
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased sacral vertebrae num... 2 | 62
increased vertical activity 2 | 18
pallor 2 | 13
thrombocytosis 2 | 23
tremors 2 | 34
vertebral fusion 2 | 23

Disease

dermatomyositis 933 | 933
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Liver and Pancreas 930 | 18,136
Endocrine System 929 | 18,512
Blood and immune system 928 | 17,995
Cardiovascular System 928 | 17,958
Digestive Tract 928 | 18,473
Female tissues 928 | 18,647
Male tissues 928 | 17,969
Nervous System 928 | 18,561
Respiratory system 928 | 17,484
Urinary Tract 928 | 18,444
Skin and soft tissues 919 | 18,115

Target Family

Non-IDG 576 | 11,971
Enzyme 208 | 4,146
Transcription Factor 46 | 1,400
Kinase 41 | 634
Epigenetic 27 | 242
Transporter 18 | 473
GPCR 7 | 406
Nuclear Receptor 4 | 48
TF/Epigenetic 4 | 38
Ion Channel 2 | 341

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100
Interleukin enhancer-binding factor 3 ILF3 Tbio Non-IDG -2.09543 135.8 239