Development Level

Tbio 686 | 10,625
Tchem 187 | 1,890
Tdark 120 | 7,003
Tclin 63 | 602

Collection

Eligible Ion Channel Proteins 7 | 117
Eligible Kinase Proteins 5 | 134
Eligible non-olfactory GPCR Proteins 5 | 145

IMPC Term

preweaning lethality, complete... 26 | 633
abnormal behavior 15 | 226
preweaning lethality, incomple... 15 | 260
abnormal bone structure 12 | 131
abnormal lens morphology 12 | 73
decreased total body fat amoun... 12 | 186
decreased bone mineral content 11 | 157
embryonic lethality prior to t... 11 | 187
decreased lean body mass 10 | 195
increased mean corpuscular vol... 10 | 91
decreased body length 9 | 108
decreased body weight 9 | 174
decreased grip strength 9 | 123
enlarged heart 9 | 111
hypoactivity 9 | 89
increased bone mineral content 9 | 92
increased circulating alkaline... 9 | 119
increased mean corpuscular hem... 9 | 93
male infertility 9 | 62
decreased circulating choleste... 8 | 85
decreased mean corpuscular vol... 8 | 50
increased hematocrit 8 | 36
increased lean body mass 8 | 107
short tibia 8 | 82
abnormal retina morphology 7 | 100
decreased bone mineral density 7 | 126
decreased circulating HDL chol... 7 | 77
decreased circulating glucose ... 7 | 121
decreased circulating insulin ... 7 | 75
decreased circulating serum al... 7 | 79
decreased circulating triglyce... 7 | 83
embryonic lethality prior to o... 7 | 148
increased circulating calcium ... 7 | 32
thrombocytopenia 7 | 46
abnormal coat/hair pigmentatio... 6 | 54
female infertility 6 | 34
increased circulating HDL chol... 6 | 63
cataract 5 | 26
decreased erythrocyte cell num... 5 | 43
decreased hemoglobin content 5 | 53
increased circulating choleste... 5 | 53
increased circulating serum al... 5 | 25
increased erythrocyte cell num... 5 | 26
increased grip strength 5 | 83
increased hemoglobin content 5 | 45
increased total body fat amoun... 5 | 57
abnormal heart morphology 4 | 51
abnormal sleep behavior 4 | 63
corneal opacity 4 | 25
decreased caudal vertebrae num... 4 | 49
decreased circulating alanine ... 4 | 53
decreased circulating total pr... 4 | 41
decreased fasted circulating g... 4 | 49
decreased heart weight 4 | 44
decreased leukocyte cell numbe... 4 | 54
decreased mean corpuscular hem... 4 | 34
hyperactivity 4 | 108
impaired glucose tolerance 4 | 52
improved glucose tolerance 4 | 56
increased bone mineral density 4 | 52
increased circulating sodium l... 4 | 71
increased leukocyte cell numbe... 4 | 37
persistence of hyaloid vascula... 4 | 22
abnormal behavioral response t... 3 | 52
abnormal cranium morphology 3 | 32
abnormal embryo size 3 | 112
abnormal kidney morphology 3 | 30
abnormal neural tube closure 3 | 37
abnormal spleen morphology 3 | 36
decreased CD8-positive, alpha-... 3 | 26
decreased NK T cell number 3 | 28
decreased T cell number 3 | 31
decreased blood urea nitrogen ... 3 | 31
decreased circulating LDL chol... 3 | 37
decreased circulating free fat... 3 | 39
decreased circulating glycerol... 3 | 19
decreased hematocrit 3 | 25
decreased mean platelet volume 3 | 12
decreased monocyte cell number 3 | 28
decreased threshold for audito... 3 | 32
impaired righting response 3 | 19
increased blood urea nitrogen ... 3 | 44
increased body weight 3 | 42
increased circulating iron lev... 3 | 25
increased circulating potassiu... 3 | 31
increased circulating total pr... 3 | 20
increased fasted circulating g... 3 | 68
increased monocyte cell number 3 | 27
increased or absent threshold ... 3 | 128
increased rib number 3 | 41
limb grasping 3 | 35
abnormal cornea morphology 2 | 24
abnormal optic disc morphology 2 | 10
cardiovascular system phenotyp... 2 | 35
decreased circulating potassiu... 2 | 17
decreased lumbar vertebrae num... 2 | 62
increased circulating chloride... 2 | 43
small testis 2 | 37
tremors 2 | 34
vertebral fusion 2 | 23

Disease

cutaneous lupus erythematosus 1,056 | 1,056
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 1,047 | 18,561
Digestive Tract 1,046 | 18,473
Urinary Tract 1,045 | 18,444
Liver and Pancreas 1,044 | 18,136
Male tissues 1,044 | 17,969
Endocrine System 1,043 | 18,512
Female tissues 1,043 | 18,647
Blood and immune system 1,039 | 17,995
Cardiovascular System 1,039 | 17,958
Skin and soft tissues 1,039 | 18,115
Respiratory system 1,038 | 17,484

Target Family

Non-IDG 632 | 11,969
Enzyme 222 | 4,146
Transcription Factor 73 | 1,400
Kinase 36 | 634
GPCR 31 | 408
Transporter 29 | 473
Ion Channel 21 | 341
Nuclear Receptor 6 | 48
TF/Epigenetic 5 | 38
Epigenetic 1 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Signaling threshold-regulating transmembrane adapter 1 SIT1 Tdark Non-IDG -0.57897 3.19 141
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Chemokine-like receptor 1 CMKLR1 Tchem GPCR -2.09993 116.0 343
Noelin OLFM1 Tbio Non-IDG -1.26710 24.7 286
Glycerophosphoinositol inositolphosphodiesterase GDPD2 GDPD2 Tbio Enzyme -0.90490 7.85 84
E3 ISG15--protein ligase HERC5 HERC5 Tbio Enzyme -1.59626 41.3 53
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.22244 1606.1 561