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Development Level

Tbio 1,058 | 11,445
Tchem 189 | 1,598
Tdark 137 | 6,588
Tclin 94 | 613

Collection

RFA-RM-18-021 11 | 328
Kinase: IDG Consortium (Target... 5 | 125
Ion Channel: IDG Consortium (T... 4 | 99
GPCR: IDG Consortium (Targets) 3 | 126
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 75 | 979
preweaning lethality, incomple... 53 | 499
abnormal behavior 28 | 298
embryonic lethality prior to t... 26 | 278
enlarged heart 26 | 210
decreased vertical activity 23 | 208
decreased body weight 21 | 161
decreased total body fat amoun... 21 | 207
abnormal embryo size 20 | 220
embryonic lethality prior to o... 19 | 239
increased total body fat amoun... 18 | 134
abnormal bone structure 17 | 187
abnormal heart morphology 17 | 162
decreased lean body mass 17 | 135
increased lean body mass 17 | 172
decreased grip strength 16 | 116
increased startle reflex 14 | 112
decreased bone mineral content 13 | 151
abnormal seminal vesicle morph... 12 | 114
decreased body length 12 | 101
decreased bone mineral density 12 | 126
hyperactivity 12 | 148
increased bone mineral content 12 | 108
increased circulating alkaline... 12 | 122
male infertility 12 | 123
decreased circulating choleste... 11 | 93
hypoactivity 11 | 132
increased mean corpuscular vol... 11 | 92
abnormal eye morphology 10 | 68
decreased circulating glucose ... 10 | 126
decreased startle reflex 10 | 75
increased or absent threshold ... 10 | 101
cataract 9 | 92
decreased fasted circulating g... 9 | 65
decreased lymphocyte cell numb... 9 | 83
decreased mean corpuscular vol... 9 | 79
decreased prepulse inhibition 9 | 82
female infertility 9 | 60
improved glucose tolerance 9 | 79
increased bone mineral density 9 | 72
increased fasted circulating g... 9 | 76
abnormal gait 8 | 69
decreased hemoglobin content 8 | 68
thrombocytopenia 8 | 56
abnormal behavioral response t... 7 | 66
abnormal locomotor behavior 7 | 24
decreased circulating insulin ... 7 | 76
decreased circulating total pr... 7 | 49
decreased leukocyte cell numbe... 7 | 73
edema 7 | 59
impaired righting response 7 | 26
increased heart weight 7 | 62
increased hematocrit 7 | 46
increased mean corpuscular hem... 7 | 96
short tibia 7 | 97
abnormal lens morphology 6 | 81
abnormal retina morphology 6 | 71
abnormal skin morphology 6 | 50
decreased circulating HDL chol... 6 | 68
decreased circulating iron lev... 6 | 32
decreased circulating serum al... 6 | 82
decreased erythrocyte cell num... 6 | 62
impaired glucose tolerance 6 | 75
increased blood urea nitrogen ... 6 | 48
increased body length 6 | 32
increased circulating calcium ... 6 | 34
increased monocyte cell number 6 | 63
limb grasping 6 | 41
prenatal lethality prior to he... 6 | 87
tremors 6 | 39
abnormal bone mineralization 5 | 38
abnormal coat-hair pigmentatio... 5 | 64
abnormal kidney morphology 5 | 65
abnormal retinal vasculature m... 5 | 27
decreased blood urea nitrogen ... 5 | 51
decreased circulating alkaline... 5 | 46
decreased circulating calcium ... 5 | 36
decreased hematocrit 5 | 46
increased circulating HDL chol... 5 | 80
increased circulating bilirubi... 5 | 16
increased circulating creatini... 5 | 38
increased leukocyte cell numbe... 5 | 47
small superior vagus ganglion 5 | 74
abnormal craniofacial morpholo... 4 | 33
abnormal cranium morphology 4 | 36
abnormal lung morphology 4 | 26
abnormal neural tube closure 4 | 46
abnormal spleen morphology 4 | 55
decreased caudal vertebrae num... 4 | 53
decreased circulating alanine ... 4 | 47
decreased circulating aspartat... 4 | 34
decreased circulating triglyce... 4 | 79
embryonic growth retardation 4 | 106
enlarged lymph nodes 4 | 37
hydrometra 4 | 53
increased circulating choleste... 4 | 66
increased circulating iron lev... 4 | 30
increased circulating sodium l... 4 | 71
increased circulating triglyce... 4 | 42
prolonged QT interval 4 | 38

Disease

colon cancer 1,478 | 1,478
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 1,452 | 17,369
Endocrine System 1,450 | 18,159
Female tissues 1,447 | 17,400
Skin and soft tissues 1,446 | 17,230
Liver and Pancreas 1,441 | 16,750
Urinary Tract 1,440 | 16,678
Male tissues 1,439 | 17,142
Blood and immune system 1,437 | 16,909
Respiratory system 1,421 | 16,393
Nervous System 1,420 | 16,725
Cardiovascular System 1,355 | 15,192

Target Family

Non-IDG 859 | 12,091
Enzyme 340 | 4,145
Transcription Factor 93 | 1,400
Kinase 62 | 634
Transporter 47 | 473
GPCR 32 | 408
Ion Channel 28 | 344
Epigenetic 9 | 242
Nuclear Receptor 6 | 48
TF/Epigenetic 1 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Alcohol dehydrogenase 6 ADH6 Tbio Enzyme -1.84121 71.7 117
Sorcin SRI Tbio Non-IDG -2.69915 481.5 119
Synaptotagmin-like protein 2 SYTL2 Tbio Non-IDG -1.27949 19.5 60
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0