Development Level

Tbio 991 | 10,625
Tchem 230 | 1,890
Tdark 161 | 7,003
Tclin 93 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 5 | 117
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 58 | 633
preweaning lethality, incomple... 30 | 260
abnormal behavior 23 | 226
decreased lean body mass 22 | 195
embryonic lethality prior to t... 21 | 187
decreased body weight 20 | 174
decreased total body fat amoun... 18 | 186
decreased grip strength 16 | 123
decreased bone mineral content 15 | 157
increased or absent threshold ... 15 | 128
abnormal embryo size 14 | 112
decreased body length 14 | 108
embryonic lethality prior to o... 13 | 148
increased circulating alkaline... 13 | 119
increased mean corpuscular vol... 13 | 91
abnormal bone structure 12 | 131
abnormal retina morphology 12 | 100
decreased circulating glucose ... 12 | 121
enlarged heart 12 | 111
decreased bone mineral density 11 | 126
decreased circulating choleste... 11 | 85
decreased circulating HDL chol... 10 | 77
increased bone mineral content 10 | 92
increased lean body mass 10 | 107
decreased mean corpuscular vol... 9 | 50
hyperactivity 9 | 108
increased startle reflex 9 | 38
decreased heart weight 8 | 44
decreased startle reflex 8 | 48
improved glucose tolerance 8 | 56
increased circulating calcium ... 8 | 32
increased fasted circulating g... 8 | 68
increased mean corpuscular hem... 8 | 93
short tibia 8 | 82
abnormal bone mineralization 7 | 55
decreased circulating serum al... 7 | 79
decreased circulating triglyce... 7 | 83
decreased eosinophil cell numb... 7 | 41
decreased lumbar vertebrae num... 7 | 62
decreased prepulse inhibition 7 | 52
female infertility 7 | 34
hypoactivity 7 | 89
increased exploration in new e... 7 | 56
thrombocytopenia 7 | 46
decreased caudal vertebrae num... 6 | 49
decreased circulating alanine ... 6 | 53
decreased circulating insulin ... 6 | 75
decreased circulating total pr... 6 | 41
decreased fasted circulating g... 6 | 49
decreased leukocyte cell numbe... 6 | 54
increased blood urea nitrogen ... 6 | 44
increased grip strength 6 | 83
increased hematocrit 6 | 36
increased sacral vertebrae num... 6 | 62
prenatal lethality prior to he... 6 | 64
abnormal gait 5 | 51
abnormal heart morphology 5 | 51
abnormal lens morphology 5 | 73
abnormal seminal vesicle morph... 5 | 47
cardiovascular system phenotyp... 5 | 35
decreased circulating free fat... 5 | 39
decreased erythrocyte cell num... 5 | 43
decreased hemoglobin content 5 | 53
impaired glucose tolerance 5 | 52
increased bone mineral density 5 | 52
increased circulating HDL chol... 5 | 63
increased circulating creatini... 5 | 29
increased total body fat amoun... 5 | 57
male infertility 5 | 62
tremors 5 | 34
abnormal coat/hair pigmentatio... 4 | 54
abnormal cranium morphology 4 | 32
abnormal eye morphology 4 | 38
abnormal hindbrain development 4 | 24
abnormal lung morphology 4 | 15
abnormal midbrain development 4 | 22
abnormal neural tube closure 4 | 37
abnormal retinal pigmentation 4 | 61
abnormal skin appearance 4 | 8
decreased circulating alkaline... 4 | 41
decreased circulating glycerol... 4 | 19
decreased circulating iron lev... 4 | 25
decreased mean corpuscular hem... 4 | 34
decreased threshold for audito... 4 | 32
hydrops fetalis 4 | 22
impaired righting response 4 | 19
increased circulating bilirubi... 4 | 16
increased circulating choleste... 4 | 53
increased circulating phosphat... 4 | 24
increased circulating sodium l... 4 | 71
increased heart weight 4 | 37
increased rib number 4 | 41
limb grasping 4 | 35
abnormal sleep behavior 3 | 63
decreased rib number 3 | 59
increased body weight 3 | 42
increased circulating potassiu... 3 | 31
increased circulating serum al... 3 | 25
increased circulating total pr... 3 | 20
increased hemoglobin content 3 | 45

Disease

colon cancer 1,475 | 1,475
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 1,462 | 18,473
Nervous System 1,462 | 18,561
Liver and Pancreas 1,461 | 18,136
Male tissues 1,460 | 17,969
Urinary Tract 1,459 | 18,444
Female tissues 1,458 | 18,647
Endocrine System 1,456 | 18,512
Cardiovascular System 1,453 | 17,958
Blood and immune system 1,452 | 17,995
Respiratory system 1,446 | 17,484
Skin and soft tissues 1,443 | 18,115

Target Family

Non-IDG 857 | 11,971
Enzyme 340 | 4,146
Transcription Factor 93 | 1,400
Kinase 61 | 634
Transporter 47 | 473
GPCR 32 | 406
Ion Channel 28 | 341
Epigenetic 9 | 242
Nuclear Receptor 6 | 48
TF/Epigenetic 1 | 38
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729