Targets

Target Filters...

This is where graphics are reside..

Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Proto-oncogene c-Fos	FOS	Tchem	Transcription Factor	-4.11560	13094.7	961
cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	Tclin	Enzyme	-3.31593	2169.0	108
Chitinase-3-like protein 1	CHI3L1	Tbio	Enzyme	-2.73776	668.3	248
ADP/ATP translocase 1	SLC25A4	Tbio	Transporter	-2.05462	110.8	89
G2/mitotic-specific cyclin-B1	CCNB1	Tchem	Non-IDG	-3.09727	1121.4	955
Forkhead box protein M1	FOXM1	Tbio	Transcription Factor	-3.09305	1275.4	345
EGF-like repeat and discoidin I-like domain-containing protein 3	EDIL3	Tbio	Non-IDG	-1.83671	93.1	157
Cardiac phospholamban	PLN	Tbio	Non-IDG	-1.89899	84.7	326
Protein Smaug homolog 1	SAMD4A	Tbio	Non-IDG		16.8	58
Interleukin-1 receptor-associated kinase 1	IRAK1	Tchem	Kinase	-2.51851	320.4	729

	Tbio	991 \| 10,625
	Tchem	230 \| 1,890
	Tdark	161 \| 7,003
	Tclin	93 \| 602

	Eligible Kinase Proteins	6 \| 134
	Eligible Ion Channel Proteins	5 \| 117
	Eligible non-olfactory GPCR Proteins	5 \| 143

	preweaning lethality, complete...	58 \| 633
	preweaning lethality, incomple...	30 \| 260
	abnormal behavior	23 \| 226
	decreased lean body mass	22 \| 195
	embryonic lethality prior to t...	21 \| 187
	decreased body weight	20 \| 174
	decreased total body fat amoun...	18 \| 186
	decreased grip strength	16 \| 123
	decreased bone mineral content	15 \| 157
	increased or absent threshold ...	15 \| 128
	abnormal embryo size	14 \| 112
	decreased body length	14 \| 108
	embryonic lethality prior to o...	13 \| 148
	increased circulating alkaline...	13 \| 119
	increased mean corpuscular vol...	13 \| 91
	abnormal bone structure	12 \| 131
	abnormal retina morphology	12 \| 100
	decreased circulating glucose ...	12 \| 121
	enlarged heart	12 \| 111
	decreased bone mineral density	11 \| 126
	decreased circulating choleste...	11 \| 85
	decreased circulating HDL chol...	10 \| 77
	increased bone mineral content	10 \| 92
	increased lean body mass	10 \| 107
	decreased mean corpuscular vol...	9 \| 50
	hyperactivity	9 \| 108
	increased startle reflex	9 \| 38
	decreased heart weight	8 \| 44
	decreased startle reflex	8 \| 48
	improved glucose tolerance	8 \| 56
	increased circulating calcium ...	8 \| 32
	increased fasted circulating g...	8 \| 68
	increased mean corpuscular hem...	8 \| 93
	short tibia	8 \| 82
	abnormal bone mineralization	7 \| 55
	decreased circulating serum al...	7 \| 79
	decreased circulating triglyce...	7 \| 83
	decreased eosinophil cell numb...	7 \| 41
	decreased lumbar vertebrae num...	7 \| 62
	decreased prepulse inhibition	7 \| 52
	female infertility	7 \| 34
	hypoactivity	7 \| 89
	increased exploration in new e...	7 \| 56
	thrombocytopenia	7 \| 46
	decreased caudal vertebrae num...	6 \| 49
	decreased circulating alanine ...	6 \| 53
	decreased circulating insulin ...	6 \| 75
	decreased circulating total pr...	6 \| 41
	decreased fasted circulating g...	6 \| 49
	decreased leukocyte cell numbe...	6 \| 54
	increased blood urea nitrogen ...	6 \| 44
	increased grip strength	6 \| 83
	increased hematocrit	6 \| 36
	increased sacral vertebrae num...	6 \| 62
	prenatal lethality prior to he...	6 \| 64
	abnormal gait	5 \| 51
	abnormal heart morphology	5 \| 51
	abnormal lens morphology	5 \| 73
	abnormal seminal vesicle morph...	5 \| 47
	cardiovascular system phenotyp...	5 \| 35
	decreased circulating free fat...	5 \| 39
	decreased erythrocyte cell num...	5 \| 43
	decreased hemoglobin content	5 \| 53
	impaired glucose tolerance	5 \| 52
	increased bone mineral density	5 \| 52
	increased circulating HDL chol...	5 \| 63
	increased circulating creatini...	5 \| 29
	increased total body fat amoun...	5 \| 57
	male infertility	5 \| 62
	tremors	5 \| 34
	abnormal coat/hair pigmentatio...	4 \| 54
	abnormal cranium morphology	4 \| 32
	abnormal eye morphology	4 \| 38
	abnormal hindbrain development	4 \| 24
	abnormal lung morphology	4 \| 15
	abnormal midbrain development	4 \| 22
	abnormal neural tube closure	4 \| 37
	abnormal retinal pigmentation	4 \| 61
	abnormal skin appearance	4 \| 8
	decreased circulating alkaline...	4 \| 41
	decreased circulating glycerol...	4 \| 19
	decreased circulating iron lev...	4 \| 25
	decreased mean corpuscular hem...	4 \| 34
	decreased threshold for audito...	4 \| 32
	hydrops fetalis	4 \| 22
	impaired righting response	4 \| 19
	increased circulating bilirubi...	4 \| 16
	increased circulating choleste...	4 \| 53
	increased circulating phosphat...	4 \| 24
	increased circulating sodium l...	4 \| 71
	increased heart weight	4 \| 37
	increased rib number	4 \| 41
	limb grasping	4 \| 35
	abnormal sleep behavior	3 \| 63
	decreased rib number	3 \| 59
	increased body weight	3 \| 42
	increased circulating potassiu...	3 \| 31
	increased circulating serum al...	3 \| 25
	increased circulating total pr...	3 \| 20
	increased hemoglobin content	3 \| 45

	colon cancer	1,475 \| 1,475
	ovarian cancer	8,484 \| 8,484
	osteosarcoma	7,933 \| 7,933
	psoriasis	6,685 \| 6,685
	medulloblastoma, large-cell	6,234 \| 6,234
	glioblastoma	5,572 \| 5,572
	lung cancer	4,466 \| 4,466
	atypical teratoid / rhabdoid tumor	4,369 \| 4,369
	intraductal papillary-mucinous neoplasm (IPMN)	3,289 \| 3,289
	malignant mesothelioma	3,162 \| 3,162
	Breast cancer	3,094 \| 3,094
	pilocytic astrocytoma	3,086 \| 3,086
	primitive neuroectodermal tumor	3,031 \| 3,031
	intraductal papillary-mucinous carcinoma (IPMC)	2,988 \| 2,988
	intraductal papillary-mucinous adenoma (IPMA)	2,956 \| 2,956
	invasive ductal carcinoma	2,950 \| 2,950
	oligodendroglioma	2,849 \| 2,849
	lung carcinoma	2,844 \| 2,844
	non-small cell lung cancer	2,798 \| 2,798
	lung adenocarcinoma	2,713 \| 2,713
	pediatric high grade glioma	2,712 \| 2,712
	ependymoma	2,514 \| 2,514
	Cancer	2,346 \| 2,346
	pancreatic cancer	2,300 \| 2,300
	interstitial cystitis	2,299 \| 2,299
	subependymal giant cell astrocytoma	2,287 \| 2,287
	group 3 medulloblastoma	2,254 \| 2,254
	astrocytic glioma	2,241 \| 2,241
	adult high grade glioma	2,148 \| 2,148
	Carcinoma	2,147 \| 2,147
	ulcerative colitis	2,087 \| 2,087
	pituitary cancer	1,972 \| 1,972
	Pick disease	1,893 \| 1,893
	group 4 medulloblastoma	1,875 \| 1,875
	pancreatic ductal adenocarcinoma liver metastasis	1,795 \| 1,795
	ductal carcinoma in situ	1,745 \| 1,745
	cystic fibrosis	1,665 \| 1,665
	diabetes mellitus	1,663 \| 1,663
	breast carcinoma	1,614 \| 1,614
	tuberculosis	1,557 \| 1,557
	posterior fossa group B ependymoma	1,530 \| 1,530
	medulloblastoma	1,524 \| 1,524
	posterior fossa group A ependymoma	1,511 \| 1,511
	astrocytoma	1,493 \| 1,493
	sonic hedgehog group medulloblastoma	1,482 \| 1,482
	adrenocortical carcinoma	1,427 \| 1,427
	Multiple myeloma	1,327 \| 1,327
	primary pancreatic ductal adenocarcinoma	1,271 \| 1,271
	juvenile dermatomyositis	1,189 \| 1,189
	Rheumatoid Arthritis	1,160 \| 1,160
	acute quadriplegic myopathy	1,157 \| 1,157
	atypical teratoid/rhabdoid tumor	1,095 \| 1,095
	spina bifida	1,064 \| 1,064
	cutaneous lupus erythematosus	1,056 \| 1,056
	nasopharyngeal carcinoma	1,056 \| 1,056
	Atopic dermatitis	944 \| 944
	dermatomyositis	933 \| 933
	active Crohn's disease	918 \| 918
	non primary Sjogren syndrome sicca	840 \| 840
	gastric carcinoma	832 \| 832
	primary Sjogren syndrome	789 \| 789
	acute myeloid leukemia	780 \| 780
	Waldenstrons macroglobulinemia	765 \| 765
	esophageal adenocarcinoma	737 \| 737
	tuberculosis and treatment for 6 months	686 \| 686
	progressive supranuclear palsy	674 \| 674
	aldosterone-producing adenoma	664 \| 664
	Alzheimer's disease	644 \| 644
	Obesity	616 \| 616
	Duchenne muscular dystrophy	602 \| 602
	Intellectual disability	573 \| 573
	pancreatic carcinoma	567 \| 567
	fibroadenoma	557 \| 557
	Down syndrome	548 \| 548
	Endometriosis	535 \| 535
	hepatocellular carcinoma	532 \| 532
	chronic rhinosinusitis	512 \| 512
	Schizophrenia	501 \| 501
	autosomal dominant Emery-Dreifuss muscular dystrophy	499 \| 499
	Multiple Sclerosis	498 \| 498
	mucosa-associated lymphoid tissue lymphoma	480 \| 480
	active ulcerative colitis	477 \| 477
	Prostatic Neoplasms	471 \| 471
	IGA Glomerulonephritis	454 \| 454
	Amyotrophic Lateral Sclerosis	431 \| 431
	gastric cancer	430 \| 430
	non-small cell lung carcinoma	413 \| 413
	Mammary Neoplasms	410 \| 410
	inflammatory breast cancer	404 \| 404
	Kidney disease	396 \| 396
	Neurodegenerative disease	383 \| 383
	Parkinson's disease	364 \| 364
	sarcoidosis	358 \| 358
	Asthma	349 \| 349
	glioblastoma multiforme	347 \| 347
	Epilepsy	346 \| 346
	Polycystic Ovary Syndrome	332 \| 332
	nephrosclerosis	329 \| 329
	tuberculosis and treatment for 3 months	327 \| 327
	Autistic Disorder	320 \| 320

	Digestive Tract	1,462 \| 18,473
	Nervous System	1,462 \| 18,561
	Liver and Pancreas	1,461 \| 18,136
	Male tissues	1,460 \| 17,969
	Urinary Tract	1,459 \| 18,444
	Female tissues	1,458 \| 18,647
	Endocrine System	1,456 \| 18,512
	Cardiovascular System	1,453 \| 17,958
	Blood and immune system	1,452 \| 17,995
	Respiratory system	1,446 \| 17,484
	Skin and soft tissues	1,443 \| 18,115

Development Level

Collection

IMPC Term

Disease

Tissue

Target Family

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Grant Funding IC

Grant Activity

Data Source

	Non-IDG	857 \| 11,971
	Enzyme	340 \| 4,146
	Transcription Factor	93 \| 1,400
	Kinase	61 \| 634
	Transporter	47 \| 473
	GPCR	32 \| 406
	Ion Channel	28 \| 341
	Epigenetic	9 \| 242
	Nuclear Receptor	6 \| 48
	TF/Epigenetic	1 \| 38
	oGPCR	1 \| 421