Development Level

Tbio 288 | 10,625
Tdark 145 | 7,003
Tchem 51 | 1,890
Tclin 28 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 18 | 633
preweaning lethality, incomple... 10 | 260
decreased body weight 8 | 174
decreased lean body mass 7 | 195
abnormal embryo size 6 | 112
decreased bone mineral density 6 | 126
decreased total body fat amoun... 6 | 186
embryonic lethality prior to t... 6 | 187
abnormal behavior 5 | 226
abnormal behavioral response t... 5 | 52
decreased circulating triglyce... 5 | 83
abnormal bone mineralization 4 | 55
abnormal bone structure 4 | 131
decreased startle reflex 4 | 48
embryonic lethality prior to o... 4 | 148
enlarged heart 4 | 111
hyperactivity 4 | 108
hypoactivity 4 | 89
increased blood urea nitrogen ... 4 | 44
increased bone mineral content 4 | 92
increased lean body mass 4 | 107
increased mean corpuscular hem... 4 | 93
increased mean corpuscular vol... 4 | 91
male infertility 4 | 62
abnormal embryo turning 3 | 15
abnormal heart morphology 3 | 51
abnormal locomotor activation 3 | 26
abnormal retinal pigmentation 3 | 61
abnormal sleep behavior 3 | 63
decreased circulating insulin ... 3 | 75
decreased circulating serum al... 3 | 79
decreased erythrocyte cell num... 3 | 43
decreased prepulse inhibition 3 | 52
increased grip strength 3 | 83
increased or absent threshold ... 3 | 128
increased total body fat amoun... 3 | 57
abnormal neural tube closure 2 | 37
abnormal response to tactile s... 2 | 16
abnormal retina morphology 2 | 100
abnormal seminal vesicle morph... 2 | 47
abnormal startle reflex 2 | 14
convulsive seizures 2 | 11
decreased bone mineral content 2 | 157
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating free fat... 2 | 39
decreased circulating glucose ... 2 | 121
decreased eosinophil cell numb... 2 | 41
decreased lumbar vertebrae num... 2 | 62
decreased monocyte cell number 2 | 28
embryonic growth retardation 2 | 28
enlarged spleen 2 | 26
female infertility 2 | 34
improved glucose tolerance 2 | 56
increased bone mineral density 2 | 52
increased circulating alkaline... 2 | 119
increased circulating bilirubi... 2 | 16
increased erythrocyte cell num... 2 | 26
increased heart rate 2 | 17
increased leukocyte cell numbe... 2 | 37
increased sacral vertebrae num... 2 | 62
short tibia 2 | 82
shortened RR interval 2 | 19
small adrenal glands 2 | 15
thrombocytopenia 2 | 46
trunk curl 2 | 15
abnormal cranium morphology 1 | 32
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal rib morphology 1 | 28
abnormal sensory capabilities/... 1 | 3
abnormal testis morphology 1 | 30
abnormal whole-body plethysmog... 1 | 4
decreased Ly6C high monocyte n... 1 | 18
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased effector memory CD8-... 1 | 24
decreased exploration in new e... 1 | 9
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
increased circulating amylase ... 1 | 13
increased circulating creatini... 1 | 29
increased rib number 1 | 41
increased startle reflex 1 | 38
limb grasping 1 | 35
oligodactyly 1 | 14
prenatal lethality prior to he... 1 | 64
shortened ST segment 1 | 9
tremors 1 | 34

Disease

chronic rhinosinusitis 512 | 512
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 508 | 18,561
Digestive Tract 507 | 18,473
Endocrine System 507 | 18,512
Female tissues 507 | 18,647
Liver and Pancreas 507 | 18,136
Urinary Tract 507 | 18,444
Cardiovascular System 506 | 17,958
Male tissues 506 | 17,969
Skin and soft tissues 506 | 18,115
Respiratory system 505 | 17,484
Blood and immune system 503 | 17,995

Target Family

Non-IDG 341 | 11,971
Enzyme 94 | 4,146
Transcription Factor 28 | 1,400
Transporter 15 | 473
Kinase 14 | 634
GPCR 7 | 406
Ion Channel 6 | 341
Nuclear Receptor 5 | 48
Epigenetic 1 | 242
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Zinc-alpha-2-glycoprotein AZGP1 Tbio Non-IDG -2.14317 164.1 198
Regulator of G-protein signaling 22 RGS22 Tbio Non-IDG -0.31702 2.73 99
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A ANKRD28 Tbio Enzyme -0.56847 4.64 67
Meiosis-specific nuclear structural protein 1 MNS1 Tbio Non-IDG -1.16311 14.2 55
24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Tbio Enzyme -0.95411 6.43 97
Tetratricopeptide repeat protein 21A TTC21A Tdark Non-IDG -0.36678 2.33 4
Krueppel-like factor 9 KLF9 Tbio Transcription Factor -1.87911 88.8 139
Putative methyltransferase NSUN7 NSUN7 Tdark Enzyme -0.64137 4.34 10
WD repeat-containing protein 63 WDR63 Tdark Non-IDG -0.73038 5.69 23