Development Level

Tbio 1,091 | 10,625
Tchem 230 | 1,890
Tdark 223 | 7,003
Tclin 70 | 602

Collection

GPCR: IDG Consortium (Targets) 12 | 128
Ion Channel: IDG Consortium (Targets) 5 | 102
Kinase: IDG Consortium (Targets) 3 | 125
GPCR: IDG Consortium (Complete/Control) 1 | 24
Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 70 | 633
preweaning lethality, incomple... 40 | 260
abnormal behavior 28 | 226
embryonic lethality prior to t... 26 | 187
decreased total body fat amoun... 21 | 186
decreased lean body mass 19 | 195
abnormal embryo size 18 | 112
increased circulating alkaline... 18 | 119
increased mean corpuscular vol... 18 | 91
increased or absent threshold ... 18 | 128
embryonic lethality prior to o... 17 | 148
abnormal bone structure 15 | 131
decreased bone mineral density 15 | 126
increased lean body mass 15 | 107
decreased bone mineral content 14 | 157
decreased circulating HDL chol... 14 | 77
increased mean corpuscular hem... 14 | 93
decreased body weight 13 | 174
decreased grip strength 13 | 123
hypoactivity 13 | 89
abnormal retina morphology 12 | 100
decreased circulating choleste... 12 | 85
short tibia 12 | 82
decreased body length 11 | 108
increased bone mineral content 11 | 92
increased circulating HDL chol... 11 | 63
abnormal neural tube closure 10 | 37
decreased circulating serum al... 10 | 79
enlarged heart 10 | 111
hyperactivity 10 | 108
impaired glucose tolerance 10 | 52
abnormal bone mineralization 8 | 55
abnormal lens morphology 8 | 73
decreased caudal vertebrae num... 8 | 49
decreased circulating insulin ... 8 | 75
decreased circulating total pr... 8 | 41
decreased heart weight 8 | 44
increased grip strength 8 | 83
male infertility 8 | 62
abnormal eye morphology 7 | 38
abnormal retinal pigmentation 7 | 61
abnormal spleen morphology 7 | 36
decreased T cell number 7 | 31
decreased circulating glucose ... 7 | 121
decreased circulating triglyce... 7 | 83
decreased mean corpuscular vol... 7 | 50
decreased prepulse inhibition 7 | 52
improved glucose tolerance 7 | 56
increased blood urea nitrogen ... 7 | 44
increased circulating choleste... 7 | 53
increased fasted circulating g... 7 | 68
increased total body fat amoun... 7 | 57
abnormal coat-hair pigmentatio... 6 | 54
abnormal kidney morphology 6 | 30
decreased circulating alanine ... 6 | 53
decreased hemoglobin content 6 | 53
decreased leukocyte cell numbe... 6 | 54
decreased vertical activity 6 | 22
increased circulating calcium ... 6 | 32
increased heart weight 6 | 37
prenatal lethality prior to he... 6 | 64
abnormal heart morphology 5 | 51
abnormal hindbrain development 5 | 24
abnormal midbrain development 5 | 22
abnormal seminal vesicle morph... 5 | 47
decreased CD8-positive, alpha-... 5 | 26
decreased circulating LDL chol... 5 | 37
decreased circulating alkaline... 5 | 41
decreased circulating fructosa... 5 | 31
decreased lumbar vertebrae num... 5 | 62
decreased mean corpuscular hem... 5 | 34
decreased neutrophil cell numb... 5 | 37
decreased startle reflex 5 | 48
embryonic growth retardation 5 | 28
female infertility 5 | 34
increased bone mineral density 5 | 52
increased circulating iron lev... 5 | 25
increased circulating total pr... 5 | 20
increased exploration in new e... 5 | 56
increased hematocrit 5 | 36
increased leukocyte cell numbe... 5 | 37
abnormal gait 4 | 51
abnormal heart left ventricle ... 4 | 20
abnormal sleep behavior 4 | 63
abnormal vibrissa morphology 4 | 17
corneal opacity 4 | 25
decreased circulating bilirubi... 4 | 14
decreased circulating chloride... 4 | 32
decreased circulating glycerol... 4 | 19
decreased fasted circulating g... 4 | 49
increased circulating chloride... 4 | 43
increased circulating free fat... 4 | 17
increased heart rate 4 | 17
increased hemoglobin content 4 | 45
increased prepulse inhibition 4 | 21
increased sacral vertebrae num... 4 | 62
small testis 4 | 37
straub tail 4 | 26
thrombocytopenia 4 | 46
tremors 4 | 34

Disease

breast carcinoma 1,614 | 1,614
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 1,601 | 18,472
Female tissues 1,601 | 18,646
Liver and Pancreas 1,601 | 18,135
Nervous System 1,601 | 18,560
Male tissues 1,600 | 17,968
Urinary Tract 1,600 | 18,443
Blood and immune system 1,597 | 17,994
Endocrine System 1,597 | 18,511
Cardiovascular System 1,594 | 17,957
Respiratory system 1,592 | 17,483
Skin and soft tissues 1,589 | 18,114

Target Family

Non-IDG 984 | 11,969
Enzyme 335 | 4,146
Transcription Factor 114 | 1,400
Kinase 67 | 634
GPCR 36 | 408
Transporter 33 | 473
Ion Channel 21 | 341
Epigenetic 12 | 242
Nuclear Receptor 11 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Protein fosB FOSB Tbio Transcription Factor -2.64139 409.7 306
Glucose-fructose oxidoreductase domain-containing protein 1 GFOD1 Tdark Enzyme 0.25 0.86 22
Angiopoietin-related protein 2 ANGPTL2 Tbio Non-IDG -1.74019 67.9 132
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.13830 1.14 48
Perilipin-4 PLIN4 Tbio Non-IDG -1.18472 13.1 53
ERBB receptor feedback inhibitor 1 ERRFI1 Tbio Non-IDG -1.84249 72.2 131
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Insulin-like growth factor-binding protein 3 IGFBP3 Tchem Non-IDG -3.34747 2121.3 411
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.84839 135.6 220