Development Level

Tbio 1,091 | 10,625
Tchem 230 | 1,890
Tdark 223 | 7,003
Tclin 70 | 602

Collection

Eligible non-olfactory GPCR Proteins 10 | 143
Eligible Ion Channel Proteins 6 | 117
Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 70 | 633
preweaning lethality, incomple... 40 | 260
abnormal behavior 28 | 226
embryonic lethality prior to t... 26 | 187
decreased total body fat amoun... 21 | 186
decreased lean body mass 19 | 195
abnormal embryo size 18 | 112
increased circulating alkaline... 18 | 119
increased mean corpuscular vol... 18 | 91
increased or absent threshold ... 18 | 128
embryonic lethality prior to o... 17 | 148
abnormal bone structure 15 | 131
decreased bone mineral density 15 | 126
increased lean body mass 15 | 107
decreased bone mineral content 14 | 157
decreased circulating HDL chol... 14 | 77
increased mean corpuscular hem... 14 | 93
decreased body weight 13 | 174
decreased grip strength 13 | 123
hypoactivity 13 | 89
abnormal retina morphology 12 | 100
decreased circulating choleste... 12 | 85
short tibia 12 | 82
decreased body length 11 | 108
increased bone mineral content 11 | 92
increased circulating HDL chol... 11 | 63
abnormal neural tube closure 10 | 37
decreased circulating serum al... 10 | 79
enlarged heart 10 | 111
hyperactivity 10 | 108
impaired glucose tolerance 10 | 52
abnormal bone mineralization 8 | 55
abnormal lens morphology 8 | 73
decreased caudal vertebrae num... 8 | 49
decreased circulating insulin ... 8 | 75
decreased circulating total pr... 8 | 41
decreased heart weight 8 | 44
increased grip strength 8 | 83
male infertility 8 | 62
abnormal eye morphology 7 | 38
abnormal retinal pigmentation 7 | 61
abnormal spleen morphology 7 | 36
decreased T cell number 7 | 31
decreased circulating glucose ... 7 | 121
decreased circulating triglyce... 7 | 83
decreased mean corpuscular vol... 7 | 50
decreased prepulse inhibition 7 | 52
improved glucose tolerance 7 | 56
increased blood urea nitrogen ... 7 | 44
increased circulating choleste... 7 | 53
increased fasted circulating g... 7 | 68
increased total body fat amoun... 7 | 57
abnormal coat/hair pigmentatio... 6 | 54
abnormal kidney morphology 6 | 30
decreased circulating alanine ... 6 | 53
decreased hemoglobin content 6 | 53
decreased leukocyte cell numbe... 6 | 54
decreased vertical activity 6 | 22
increased circulating calcium ... 6 | 32
increased heart weight 6 | 37
prenatal lethality prior to he... 6 | 64
abnormal heart morphology 5 | 51
abnormal hindbrain development 5 | 24
abnormal midbrain development 5 | 22
abnormal seminal vesicle morph... 5 | 47
decreased CD8-positive, alpha-... 5 | 26
decreased circulating LDL chol... 5 | 37
decreased circulating alkaline... 5 | 41
decreased circulating fructosa... 5 | 31
decreased lumbar vertebrae num... 5 | 62
decreased mean corpuscular hem... 5 | 34
decreased neutrophil cell numb... 5 | 37
decreased startle reflex 5 | 48
embryonic growth retardation 5 | 28
female infertility 5 | 34
increased bone mineral density 5 | 52
increased circulating iron lev... 5 | 25
increased circulating total pr... 5 | 20
increased exploration in new e... 5 | 56
increased hematocrit 5 | 36
increased leukocyte cell numbe... 5 | 37
abnormal gait 4 | 51
abnormal heart left ventricle ... 4 | 20
abnormal sleep behavior 4 | 63
abnormal vibrissa morphology 4 | 17
corneal opacity 4 | 25
decreased circulating bilirubi... 4 | 14
decreased circulating chloride... 4 | 32
decreased circulating glycerol... 4 | 19
decreased fasted circulating g... 4 | 49
increased circulating chloride... 4 | 43
increased circulating free fat... 4 | 17
increased heart rate 4 | 17
increased hemoglobin content 4 | 45
increased prepulse inhibition 4 | 21
increased sacral vertebrae num... 4 | 62
small testis 4 | 37
straub tail 4 | 26
thrombocytopenia 4 | 46
tremors 4 | 34

Disease

breast carcinoma 1,614 | 1,614
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 1,601 | 18,473
Female tissues 1,601 | 18,647
Liver and Pancreas 1,601 | 18,136
Nervous System 1,601 | 18,561
Male tissues 1,600 | 17,969
Urinary Tract 1,600 | 18,444
Blood and immune system 1,597 | 17,995
Endocrine System 1,597 | 18,512
Cardiovascular System 1,594 | 17,958
Respiratory system 1,592 | 17,484
Skin and soft tissues 1,589 | 18,115

Target Family

Non-IDG 984 | 11,971
Enzyme 335 | 4,146
Transcription Factor 114 | 1,400
Kinase 67 | 634
GPCR 36 | 406
Transporter 33 | 473
Ion Channel 21 | 341
Epigenetic 12 | 242
Nuclear Receptor 11 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277