Targets

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Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Isobutyryl-CoA dehydrogenase, mitochondrial	ACAD8	Tbio	Enzyme	-1.14784	13.9	150
Formimidoyltransferase-cyclodeaminase	FTCD	Tbio	Enzyme	-2.23276	170.0	418
Probable lysosomal cobalamin transporter	LMBRD1	Tbio	Non-IDG	-2.10518	126.1	54
Acetyl-CoA acetyltransferase, cytosolic	ACAT2	Tbio	Enzyme	-1.75917	52.6	283
3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	Tbio	Enzyme	-2.13468	132.4	359
3-ketoacyl-CoA thiolase, mitochondrial	ACAA2	Tbio	Enzyme	-1.80293	59.7	223
Long-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADL	Tbio	Enzyme	-1.52646	31.4	231
Calcium-binding mitochondrial carrier protein Aralar2	SLC25A13	Tbio	Transporter	-2.27093	198.5	148
Electron transfer flavoprotein subunit alpha, mitochondrial	ETFA	Tbio	Non-IDG	-2.50402	315.3	241
3-ketoacyl-CoA thiolase, peroxisomal	ACAA1	Tbio	Enzyme	-2.31883	203.8	197

	Tbio	12 \| 11,445
	Tchem	1 \| 1,598

	abnormal embryo size	2 \| 220
	preweaning lethality, complete...	2 \| 979
	abnormal body wall morphology	1 \| 9
	anophthalmia	1 \| 33
	decreased circulating alkaline...	1 \| 46
	embryonic lethality prior to o...	1 \| 239
	embryonic lethality prior to t...	1 \| 278
	increased body length	1 \| 32
	microphthalmia	1 \| 26

	beta-ketothiolase deficiency	13 \| 13
	Carcinoma	11,493 \| 11,493
	ovarian cancer	8,520 \| 8,520
	osteosarcoma	7,950 \| 7,950
	psoriasis	6,694 \| 6,694
	medulloblastoma, large-cell	6,241 \| 6,241
	glioblastoma	5,792 \| 5,792
	atypical teratoid / rhabdoid tumor	5,112 \| 5,112
	lung cancer	4,740 \| 4,740
	ependymoma	4,679 \| 4,679
	group 3 medulloblastoma	4,104 \| 4,104
	adult high grade glioma	3,801 \| 3,801
	Breast cancer	3,578 \| 3,578
	intraductal papillary-mucinous neoplasm (IPMN)	3,291 \| 3,291
	malignant mesothelioma	3,232 \| 3,232
	Astrocytoma, Pilocytic	3,081 \| 3,081
	primitive neuroectodermal tumor	3,035 \| 3,035
	intraductal papillary-mucinous carcinoma (IPMC)	2,989 \| 2,989
	intraductal papillary-mucinous adenoma (IPMA)	2,955 \| 2,955
	invasive ductal carcinoma	2,951 \| 2,951
	non-small cell lung cancer	2,890 \| 2,890
	oligodendroglioma	2,850 \| 2,850
	lung carcinoma	2,843 \| 2,843
	lung adenocarcinoma	2,716 \| 2,716
	Kidney cancer	2,613 \| 2,613
	astrocytic glioma	2,597 \| 2,597
	Cancer	2,499 \| 2,499
	pancreatic cancer	2,398 \| 2,398
	interstitial cystitis	2,312 \| 2,312
	subependymal giant cell astrocytoma	2,287 \| 2,287
	tuberculosis	2,010 \| 2,010
	pituitary cancer	1,972 \| 1,972
	pancreatic ductal adenocarcinoma liver metastasis	1,962 \| 1,962
	Pick disease	1,894 \| 1,894
	group 4 medulloblastoma	1,855 \| 1,855
	ulcerative colitis	1,819 \| 1,819
	ductal carcinoma in situ	1,745 \| 1,745
	diabetes mellitus	1,728 \| 1,728
	cystic fibrosis	1,696 \| 1,696
	breast carcinoma	1,638 \| 1,638
	colon cancer	1,478 \| 1,478
	Autosomal recessive predisposition	1,442 \| 1,442
	adrenocortical carcinoma	1,428 \| 1,428
	Multiple myeloma	1,332 \| 1,332
	Rheumatoid arthritis	1,191 \| 1,191
	juvenile dermatomyositis	1,187 \| 1,187
	Schizophrenia	1,160 \| 1,160
	acute quadriplegic myopathy	1,158 \| 1,158
	astrocytoma	1,146 \| 1,146
	primary pancreatic ductal adenocarcinoma	1,109 \| 1,109
	spina bifida	1,074 \| 1,074
	pediatric high grade glioma	1,064 \| 1,064
	nasopharyngeal carcinoma	1,058 \| 1,058
	cutaneous lupus erythematosus	1,057 \| 1,057
	Intellectual disability	1,016 \| 1,016
	dermatomyositis	966 \| 966
	Atopic dermatitis	952 \| 952
	active Crohn's disease	922 \| 922
	non primary Sjogren syndrome sicca	891 \| 891
	gastric carcinoma	807 \| 807
	Epilepsy	792 \| 792
	acute myeloid leukemia	783 \| 783
	Liver Cirrhosis, Experimental	769 \| 769
	Waldenstrons macroglobulinemia	765 \| 765
	active ulcerative colitis	764 \| 764
	esophageal adenocarcinoma	737 \| 737
	primary Sjogren syndrome	735 \| 735
	medulloblastoma	720 \| 720
	Melanoma	711 \| 711
	Obesity	678 \| 678
	progressive supranuclear palsy	676 \| 676
	Bipolar Disorder	666 \| 666
	aldosterone-producing adenoma	665 \| 665
	Alzheimer's disease	658 \| 658
	Dull intelligence	645 \| 645
	Low intelligence	645 \| 645
	Mental Retardation	645 \| 645
	Mental deficiency	645 \| 645
	Poor school performance	645 \| 645
	Cognitive delay	608 \| 608
	Global developmental delay	608 \| 608
	Mental and motor retardation	608 \| 608
	Liver cancer	604 \| 604
	Duchenne muscular dystrophy	601 \| 601
	Seizures	596 \| 596
	Muscle hypotonia	571 \| 571
	pancreatic carcinoma	562 \| 562
	fibroadenoma	559 \| 559
	hepatocellular carcinoma	547 \| 547
	Endometriosis	540 \| 540
	Multiple Sclerosis	540 \| 540
	Short stature	531 \| 531
	chronic rhinosinusitis	512 \| 512
	autosomal dominant Emery-Dreifuss muscular dystrophy	510 \| 510
	Down syndrome	499 \| 499
	Prostatic Neoplasms	495 \| 495
	mucosa-associated lymphoid tissue lymphoma	484 \| 484
	Skin cancer	469 \| 469
	posterior fossa group A ependymoma	468 \| 468
	sonic hedgehog group medulloblastoma	467 \| 467
	gastric cancer	459 \| 459

	Blood and immune system	13 \| 16,909
	Cardiovascular System	13 \| 15,192
	Digestive Tract	13 \| 17,369
	Endocrine System	13 \| 18,159
	Female tissues	13 \| 17,400
	Liver and Pancreas	13 \| 16,750
	Male tissues	13 \| 17,142
	Nervous System	13 \| 16,725
	Skin and soft tissues	13 \| 17,230
	Urinary Tract	13 \| 16,678
	Respiratory system	12 \| 16,393

Development Level

IMPC Phenotype

Disease

Tissue

Target Family

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Data Source

	Enzyme	10 \| 4,145
	Non-IDG	2 \| 12,091
	Transporter	1 \| 473