Development Level

Tbio 360 | 10,625
Tchem 79 | 1,890
Tdark 49 | 7,003
Tclin 11 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible Ion Channel Proteins 1 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 15 | 633
preweaning lethality, incomple... 12 | 260
abnormal behavior 10 | 226
decreased total body fat amoun... 10 | 186
increased bone mineral content 9 | 92
decreased body weight 8 | 174
embryonic lethality prior to t... 8 | 187
increased lean body mass 8 | 107
decreased grip strength 7 | 123
decreased bone mineral density 6 | 126
decreased circulating HDL chol... 6 | 77
decreased lean body mass 6 | 195
increased mean corpuscular vol... 6 | 91
abnormal bone mineralization 5 | 55
abnormal bone structure 5 | 131
abnormal coat/hair pigmentatio... 5 | 54
abnormal retina morphology 5 | 100
decreased circulating insulin ... 5 | 75
hypoactivity 5 | 89
increased circulating alkaline... 5 | 119
increased mean corpuscular hem... 5 | 93
abnormal embryo size 4 | 112
abnormal retinal pigmentation 4 | 61
decreased bone mineral content 4 | 157
decreased caudal vertebrae num... 4 | 49
decreased circulating choleste... 4 | 85
decreased heart weight 4 | 44
decreased prepulse inhibition 4 | 52
enlarged heart 4 | 111
increased bone mineral density 4 | 52
abnormal eye morphology 3 | 38
abnormal hindbrain development 3 | 24
abnormal lens morphology 3 | 73
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
decreased circulating alanine ... 3 | 53
decreased circulating free fat... 3 | 39
decreased circulating glucose ... 3 | 121
decreased circulating serum al... 3 | 79
decreased leukocyte cell numbe... 3 | 54
embryonic lethality prior to o... 3 | 148
increased circulating chloride... 3 | 43
increased circulating phosphat... 3 | 24
increased fasted circulating g... 3 | 68
increased or absent threshold ... 3 | 128
increased vertical activity 3 | 18
short tibia 3 | 82
thrombocytopenia 3 | 46
abnormal QRS complex 2 | 25
abnormal coat/ hair morphology 2 | 18
abnormal coping response 2 | 12
abnormal forebrain development 2 | 18
abnormal heart morphology 2 | 51
abnormal lung morphology 2 | 15
abnormal spinal cord morpholog... 2 | 8
decreased circulating creatini... 2 | 31
decreased circulating fructosa... 2 | 31
decreased circulating potassiu... 2 | 17
decreased fasted circulating g... 2 | 49
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 19
decreased spleen weight 2 | 13
decreased threshold for audito... 2 | 32
decreased vertical activity 2 | 22
enlarged liver 2 | 3
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased blood urea nitrogen ... 2 | 44
increased body weight 2 | 42
increased circulating free fat... 2 | 17
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased respiratory quotient 2 | 12
increased sacral vertebrae num... 2 | 62
increased total body fat amoun... 2 | 57
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
shortened ST segment 2 | 9
tremors 2 | 34
abnormal locomotor activation 1 | 26
abnormal tooth morphology 1 | 24
convulsive seizures 1 | 11
corneal opacity 1 | 25
decreased effector memory CD8-... 1 | 24
decreased mean corpuscular vol... 1 | 50
decreased total retina thickne... 1 | 20
female infertility 1 | 34
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
lethargy 1 | 5
prenatal lethality 1 | 16
straub tail 1 | 26

Disease

autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Male tissues 499 | 17,969
Digestive Tract 498 | 18,473
Endocrine System 498 | 18,512
Female tissues 498 | 18,647
Liver and Pancreas 498 | 18,136
Nervous System 498 | 18,561
Urinary Tract 498 | 18,444
Blood and immune system 497 | 17,995
Cardiovascular System 497 | 17,958
Respiratory system 496 | 17,484
Skin and soft tissues 493 | 18,115

Target Family

Non-IDG 331 | 11,971
Enzyme 88 | 4,146
Transcription Factor 37 | 1,400
Kinase 18 | 634
Transporter 12 | 473
GPCR 5 | 406
Ion Channel 4 | 341
Epigenetic 2 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Serine/arginine repetitive matrix protein 2 SRRM2 Tbio Non-IDG -1.90106 71.6 51
Laminin subunit alpha-2 LAMA2 Tbio Non-IDG -2.48634 321.9 131