Development Level

Tbio 394 | 11,445
Tchem 63 | 1,598
Tdark 42 | 6,588
Tclin 11 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 28 | 979
preweaning lethality, incomple... 18 | 499
decreased total body fat amoun... 11 | 207
abnormal behavior 10 | 298
embryonic lethality prior to t... 10 | 278
decreased body weight 9 | 161
enlarged heart 9 | 210
increased bone mineral content 9 | 108
increased lean body mass 9 | 172
hypoactivity 7 | 132
increased bone mineral density 7 | 72
increased mean corpuscular vol... 7 | 92
abnormal coat-hair pigmentatio... 6 | 64
abnormal embryo size 6 | 220
decreased bone mineral content 6 | 151
decreased bone mineral density 6 | 126
decreased lean body mass 6 | 135
decreased vertical activity 6 | 208
abnormal bone structure 5 | 187
abnormal heart morphology 5 | 162
decreased circulating HDL chol... 5 | 68
decreased circulating choleste... 5 | 93
decreased grip strength 5 | 116
embryonic growth retardation 5 | 106
increased fasted circulating g... 5 | 76
increased startle reflex 5 | 112
abnormal bone mineralization 4 | 38
abnormal eye morphology 4 | 68
cataract 4 | 92
decreased caudal vertebrae num... 4 | 53
decreased circulating LDL chol... 4 | 38
decreased circulating glucose ... 4 | 126
decreased circulating insulin ... 4 | 76
decreased heart weight 4 | 27
decreased leukocyte cell numbe... 4 | 73
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular hem... 4 | 31
impaired glucose tolerance 4 | 75
increased heart weight 4 | 62
prenatal lethality prior to he... 4 | 87
abnormal coat- hair morphology 3 | 19
abnormal lung morphology 3 | 26
abnormal retina morphology 3 | 71
decreased circulating alanine ... 3 | 47
decreased neutrophil cell numb... 3 | 42
decreased prepulse inhibition 3 | 82
embryonic lethality prior to o... 3 | 239
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 96
increased mean corpuscular hem... 3 | 36
increased monocyte cell number 3 | 63
increased total body fat amoun... 3 | 134
short tibia 3 | 97
thrombocytopenia 3 | 56
tremors 3 | 39
abnormal coat appearance 2 | 31
abnormal epididymis morphology 2 | 42
abnormal femur morphology 2 | 14
abnormal joint morphology 2 | 23
abnormal lens morphology 2 | 81
abnormal locomotor behavior 2 | 24
abnormal pericardium morpholog... 2 | 26
abnormal seminal vesicle morph... 2 | 114
abnormal sensory capabilities-... 2 | 8
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
brachydactyly 2 | 19
corneal opacity 2 | 32
decreased body length 2 | 101
decreased circulating creatini... 2 | 39
decreased circulating free fat... 2 | 31
decreased circulating potassiu... 2 | 20
decreased circulating serum al... 2 | 82
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
enlarged epididymis 2 | 31
enlarged spleen 2 | 41
increased blood urea nitrogen ... 2 | 48
increased body length 2 | 32
increased body weight 2 | 25
increased circulating HDL chol... 2 | 80
increased circulating bilirubi... 2 | 16
increased circulating calcium ... 2 | 34
increased circulating glucose ... 2 | 24
increased circulating phosphat... 2 | 26
increased circulating triglyce... 2 | 42
increased heart rate 2 | 23
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
increased vertical activity 2 | 24
limb grasping 2 | 41
shortened ST segment 2 | 10
small seminal vesicle 2 | 10
syndactyly 2 | 23

Disease

autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 506 | 18,159
Skin and soft tissues 506 | 17,230
Digestive Tract 505 | 17,369
Male tissues 505 | 17,142
Cardiovascular System 503 | 15,192
Female tissues 503 | 17,400
Nervous System 503 | 16,725
Liver and Pancreas 502 | 16,750
Blood and immune system 501 | 16,909
Urinary Tract 501 | 16,678
Respiratory system 497 | 16,393

Target Family

Non-IDG 339 | 12,091
Enzyme 90 | 4,145
Transcription Factor 37 | 1,400
Kinase 18 | 634
Transporter 13 | 473
GPCR 5 | 408
Ion Channel 4 | 344
Epigenetic 2 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
CKLF-like MARVEL transmembrane domain-containing protein 6 CMTM6 Tdark Non-IDG -0.56950 2.80 85
Serine/threonine-protein kinase MRCK beta CDC42BPB Tbio Kinase -0.59618 3.72 111
LHFPL tetraspan subfamily member 6 protein LHFPL6 Tdark Non-IDG -0.47054 2.66 66
CD109 antigen CD109 Tbio Non-IDG -1.85817 77.8 239
WD repeat and SOCS box-containing protein 1 WSB1 Tbio Non-IDG -1.13058 13.3 63
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
Epithelial membrane protein 1 EMP1 Tbio Non-IDG -2.60119 387.7 88
Tubulin beta-6 chain TUBB6 Tclin Non-IDG -0.94163 8.01 85
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295