Development Level

Tbio 2,697 | 10,625
Tdark 1,017 | 7,003
Tchem 482 | 1,890
Tclin 173 | 602

Collection

Eligible Ion Channel Proteins 35 | 117
Eligible Kinase Proteins 33 | 134
Eligible non-olfactory GPCR Proteins 19 | 143

IMPC Term

preweaning lethality, complete... 156 | 633
preweaning lethality, incomple... 89 | 260
abnormal behavior 84 | 226
decreased lean body mass 66 | 195
decreased total body fat amoun... 64 | 186
decreased bone mineral content 60 | 157
decreased body weight 53 | 174
embryonic lethality prior to t... 52 | 187
decreased grip strength 48 | 123
hyperactivity 44 | 108
decreased body length 43 | 108
abnormal bone structure 42 | 131
decreased bone mineral density 42 | 126
increased lean body mass 42 | 107
increased or absent threshold ... 41 | 128
increased circulating alkaline... 38 | 119
decreased circulating choleste... 37 | 85
hypoactivity 35 | 89
decreased circulating HDL chol... 34 | 77
short tibia 34 | 82
abnormal embryo size 33 | 112
abnormal retina morphology 33 | 100
embryonic lethality prior to o... 31 | 148
increased bone mineral content 30 | 92
decreased circulating glucose ... 29 | 121
decreased circulating triglyce... 29 | 83
increased mean corpuscular vol... 29 | 91
decreased circulating serum al... 28 | 79
abnormal lens morphology 27 | 73
increased mean corpuscular hem... 25 | 93
abnormal sleep behavior 24 | 63
decreased prepulse inhibition 24 | 52
enlarged heart 24 | 111
increased fasted circulating g... 23 | 68
increased grip strength 23 | 83
abnormal coat/hair pigmentatio... 22 | 54
decreased fasted circulating g... 22 | 49
decreased lumbar vertebrae num... 22 | 62
abnormal gait 21 | 51
decreased mean corpuscular vol... 21 | 50
increased sacral vertebrae num... 21 | 62
decreased circulating alanine ... 20 | 53
decreased hemoglobin content 20 | 53
male infertility 20 | 62
decreased circulating LDL chol... 19 | 37
decreased circulating insulin ... 19 | 75
decreased leukocyte cell numbe... 19 | 54
increased blood urea nitrogen ... 19 | 44
increased circulating HDL chol... 19 | 63
decreased caudal vertebrae num... 18 | 49
decreased startle reflex 17 | 48
impaired glucose tolerance 17 | 52
increased circulating chloride... 17 | 43
increased startle reflex 17 | 38
prenatal lethality prior to he... 17 | 64
abnormal bone mineralization 16 | 55
decreased erythrocyte cell num... 16 | 43
decreased rib number 16 | 59
increased circulating calcium ... 16 | 32
increased circulating choleste... 16 | 53
increased total body fat amoun... 16 | 57
decreased circulating total pr... 15 | 41
decreased heart weight 15 | 44
improved glucose tolerance 15 | 56
increased circulating sodium l... 15 | 71
thrombocytopenia 15 | 46
abnormal retinal pigmentation 14 | 61
tremors 14 | 34
abnormal behavioral response t... 13 | 52
decreased circulating creatini... 13 | 31
increased bone mineral density 13 | 52
increased hemoglobin content 13 | 45
limb grasping 13 | 35
abnormal heart morphology 12 | 51
cardiovascular system phenotyp... 12 | 35
decreased blood urea nitrogen ... 12 | 31
decreased circulating alkaline... 12 | 41
increased body weight 12 | 42
increased rib number 12 | 41
abnormal eye morphology 11 | 38
abnormal neural tube closure 11 | 37
abnormal rib morphology 11 | 28
decreased circulating free fat... 11 | 39
decreased circulating fructosa... 11 | 31
decreased eosinophil cell numb... 11 | 41
decreased threshold for audito... 11 | 32
increased circulating iron lev... 11 | 25
increased circulating phosphat... 11 | 24
increased exploration in new e... 11 | 56
increased heart weight 11 | 37
increased hematocrit 11 | 36
abnormal kidney morphology 10 | 30
cataract 10 | 26
decreased circulating aspartat... 10 | 27
decreased mean corpuscular hem... 10 | 34
female infertility 10 | 34
increased leukocyte cell numbe... 10 | 37
abnormal spleen morphology 9 | 36
decreased vertical activity 9 | 22
increased circulating potassiu... 9 | 31

Disease

atypical teratoid / rhabdoid tumor 4,369 | 4,369
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 4,333 | 18,561
Female tissues 4,331 | 18,647
Digestive Tract 4,329 | 18,473
Liver and Pancreas 4,321 | 18,136
Endocrine System 4,317 | 18,512
Urinary Tract 4,317 | 18,444
Cardiovascular System 4,312 | 17,958
Male tissues 4,303 | 17,969
Blood and immune system 4,302 | 17,995
Skin and soft tissues 4,293 | 18,115
Respiratory system 4,278 | 17,484

Target Family

Non-IDG 2,546 | 11,971
Enzyme 925 | 4,146
Transcription Factor 306 | 1,400
Kinase 190 | 634
Transporter 121 | 473
Ion Channel 104 | 341
GPCR 79 | 406
Epigenetic 73 | 242
Nuclear Receptor 12 | 48
TF/Epigenetic 8 | 38
oGPCR 5 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Nuclear cap-binding protein subunit 3 NCBP3 Tbio Non-IDG -1.68208 49.3 22
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Monocarboxylate transporter 14 SLC16A14 Tdark Transporter -0.69265 4.88 34