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Target Filters...

Development Level

Tbio 3,357 | 11,445
Tdark 1,041 | 6,588
Tchem 509 | 1,598
Tclin 205 | 613

Collection

RFA-RM-18-021 93 | 328
Ion Channel: IDG Consortium (T... 38 | 99
Kinase: IDG Consortium (Target... 36 | 125
GPCR: IDG Consortium (Targets) 19 | 126
Kinase: IDG Consortium (Comple... 13 | 37
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 266 | 979
preweaning lethality, incomple... 191 | 499
abnormal behavior 123 | 298
decreased total body fat amoun... 90 | 207
embryonic lethality prior to t... 86 | 278
abnormal bone structure 74 | 187
increased lean body mass 71 | 172
abnormal embryo size 68 | 220
embryonic lethality prior to o... 68 | 239
hyperactivity 62 | 148
decreased vertical activity 59 | 208
decreased body weight 58 | 161
decreased bone mineral content 55 | 151
enlarged heart 55 | 210
hypoactivity 55 | 132
increased bone mineral content 53 | 108
decreased grip strength 50 | 116
increased circulating alkaline... 50 | 122
decreased lean body mass 46 | 135
increased total body fat amoun... 46 | 134
abnormal heart morphology 42 | 162
decreased body length 42 | 101
increased startle reflex 42 | 112
decreased bone mineral density 41 | 126
short tibia 41 | 97
decreased prepulse inhibition 40 | 82
male infertility 40 | 123
decreased circulating choleste... 39 | 93
increased or absent threshold ... 38 | 101
cataract 34 | 92
decreased lymphocyte cell numb... 34 | 83
abnormal lens morphology 33 | 81
decreased circulating glucose ... 33 | 126
decreased startle reflex 33 | 75
decreased circulating serum al... 32 | 82
increased mean corpuscular vol... 32 | 92
abnormal gait 31 | 69
abnormal seminal vesicle morph... 31 | 114
decreased circulating HDL chol... 31 | 68
decreased mean corpuscular vol... 31 | 79
embryonic growth retardation 31 | 106
decreased circulating triglyce... 30 | 79
increased mean corpuscular hem... 30 | 96
improved glucose tolerance 29 | 79
increased circulating HDL chol... 29 | 80
increased fasted circulating g... 28 | 76
increased heart weight 28 | 62
abnormal sleep behavior 27 | 70
decreased fasted circulating g... 27 | 65
increased bone mineral density 27 | 72
decreased hemoglobin content 25 | 68
abnormal coat-hair pigmentatio... 24 | 64
increased circulating choleste... 24 | 66
decreased leukocyte cell numbe... 23 | 73
abnormal eye morphology 22 | 68
decreased circulating alanine ... 22 | 47
decreased circulating insulin ... 22 | 76
decreased erythrocyte cell num... 22 | 62
increased circulating triglyce... 22 | 42
prenatal lethality prior to he... 22 | 87
abnormal behavioral response t... 21 | 66
decreased circulating total pr... 21 | 49
small superior vagus ganglion 21 | 74
abnormal kidney morphology 20 | 65
abnormal spleen morphology 20 | 55
impaired glucose tolerance 20 | 75
increased hematocrit 20 | 46
increased monocyte cell number 20 | 63
decreased circulating LDL chol... 19 | 38
increased circulating chloride... 19 | 41
increased mean platelet volume 19 | 45
limb grasping 19 | 41
tremors 19 | 39
abnormal retina morphology 18 | 71
decreased hematocrit 18 | 46
edema 18 | 59
increased neutrophil cell numb... 18 | 46
small testis 18 | 58
decreased caudal vertebrae num... 17 | 53
decreased circulating alkaline... 17 | 46
decreased mean corpuscular hem... 17 | 50
decreased neutrophil cell numb... 17 | 42
female infertility 17 | 60
increased circulating calcium ... 17 | 34
abnormal cranium morphology 16 | 36
absent startle reflex 16 | 24
increased blood urea nitrogen ... 16 | 48
increased circulating sodium l... 16 | 71
increased hemoglobin content 16 | 45
increased leukocyte cell numbe... 16 | 47
increased mean corpuscular hem... 16 | 36
thrombocytopenia 16 | 56
abnormal snout morphology 15 | 23
decreased blood urea nitrogen ... 15 | 51
decreased circulating aspartat... 15 | 34
decreased circulating calcium ... 15 | 36
enlarged lymph nodes 15 | 37
hydrometra 15 | 53
increased erythrocyte cell num... 15 | 39
increased red blood cell distr... 15 | 34

Disease

atypical teratoid / rhabdoid tumor 5,112 | 5,112
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 5,051 | 18,159
Nervous System 5,009 | 16,725
Digestive Tract 4,991 | 17,369
Female tissues 4,987 | 17,400
Skin and soft tissues 4,982 | 17,230
Male tissues 4,962 | 17,142
Liver and Pancreas 4,911 | 16,750
Blood and immune system 4,895 | 16,909
Urinary Tract 4,892 | 16,678
Respiratory system 4,848 | 16,393
Cardiovascular System 4,647 | 15,192

Target Family

Non-IDG 2,985 | 12,091
Enzyme 1,075 | 4,145
Transcription Factor 352 | 1,400
Kinase 226 | 634
Transporter 144 | 473
Ion Channel 131 | 344
GPCR 91 | 408
Epigenetic 81 | 242
Nuclear Receptor 13 | 48
TF/Epigenetic 9 | 38
oGPCR 5 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Fibrosin-1-like protein FBRSL1 Tdark Non-IDG 0.48 0.50 58
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90