Development Level

Tbio 704 | 10,625
Tdark 218 | 7,003
Tchem 133 | 1,890
Tclin 40 | 602

Collection

Eligible Ion Channel Proteins 8 | 117
Eligible Kinase Proteins 7 | 134
Eligible non-olfactory GPCR Proteins 4 | 143

IMPC Term

preweaning lethality, complete... 27 | 633
abnormal behavior 20 | 226
preweaning lethality, incomple... 20 | 260
decreased total body fat amoun... 18 | 186
decreased body weight 15 | 174
increased or absent threshold ... 15 | 128
decreased lean body mass 14 | 195
embryonic lethality prior to t... 12 | 187
hyperactivity 12 | 108
abnormal bone structure 10 | 131
embryonic lethality prior to o... 10 | 148
enlarged heart 9 | 111
decreased grip strength 8 | 123
decreased bone mineral content 7 | 157
decreased circulating HDL chol... 7 | 77
decreased circulating choleste... 7 | 85
decreased circulating glucose ... 7 | 121
decreased circulating serum al... 7 | 79
decreased prepulse inhibition 7 | 52
decreased rib number 7 | 59
decreased startle reflex 7 | 48
increased bone mineral content 7 | 92
increased circulating alkaline... 7 | 119
corneal opacity 6 | 25
decreased body length 6 | 108
decreased bone mineral density 6 | 126
decreased circulating insulin ... 6 | 75
increased lean body mass 6 | 107
short tibia 6 | 82
abnormal cornea morphology 5 | 24
abnormal cranium morphology 5 | 32
abnormal kidney morphology 5 | 30
abnormal testis morphology 5 | 30
decreased circulating alkaline... 5 | 41
decreased circulating calcium ... 5 | 33
decreased circulating triglyce... 5 | 83
improved glucose tolerance 5 | 56
increased exploration in new e... 5 | 56
increased mean corpuscular vol... 5 | 91
male infertility 5 | 62
small testis 5 | 37
abnormal behavioral response t... 4 | 52
abnormal embryo size 4 | 112
abnormal eye morphology 4 | 38
abnormal lens morphology 4 | 73
abnormal maxilla morphology 4 | 16
abnormal retina morphology 4 | 100
abnormal seminal vesicle morph... 4 | 47
abnormal sleep behavior 4 | 63
abnormal snout morphology 4 | 18
decreased eosinophil cell numb... 4 | 41
hypoactivity 4 | 89
increased blood urea nitrogen ... 4 | 44
increased mean corpuscular hem... 4 | 93
thrombocytopenia 4 | 46
abnormal bone mineralization 3 | 55
abnormal coat/hair pigmentatio... 3 | 54
abnormal epididymis morphology 3 | 31
abnormal gait 3 | 51
abnormal retinal blood vessel ... 3 | 18
absent pinna reflex 3 | 21
absent startle reflex 3 | 15
corneal vascularization 3 | 5
decreased CD8-positive, alpha-... 3 | 26
decreased T cell number 3 | 31
decreased circulating chloride... 3 | 32
decreased circulating total pr... 3 | 41
decreased heart weight 3 | 44
decreased lumbar vertebrae num... 3 | 62
decreased threshold for audito... 3 | 32
decreased vertical activity 3 | 22
enlarged lymph nodes 3 | 27
impaired righting response 3 | 19
increased circulating HDL chol... 3 | 63
increased circulating chloride... 3 | 43
increased circulating choleste... 3 | 53
increased circulating sodium l... 3 | 71
increased heart weight 3 | 37
increased rib number 3 | 41
increased sacral vertebrae num... 3 | 62
increased thermal nociceptive ... 3 | 9
increased total body fat amoun... 3 | 57
long tibia 3 | 13
narrow eye opening 3 | 15
prenatal lethality prior to he... 3 | 64
small adrenal glands 3 | 15
small superior vagus ganglion 3 | 20
tremors 3 | 34
abnormal spleen morphology 2 | 36
abnormal tooth morphology 2 | 24
abnormal vertebrae morphology 2 | 14
decreased caudal vertebrae num... 2 | 49
decreased circulating glycerol... 2 | 19
decreased effector memory CD8-... 2 | 24
decreased hemoglobin content 2 | 53
enlarged spleen 2 | 26
female infertility 2 | 34
increased body weight 2 | 42
increased circulating bilirubi... 2 | 16
increased circulating total pr... 2 | 20

Disease

atypical teratoid/rhabdoid tumor 1,095 | 1,095
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 1,085 | 18,647
Nervous System 1,085 | 18,561
Digestive Tract 1,084 | 18,473
Blood and immune system 1,082 | 17,995
Male tissues 1,082 | 17,969
Endocrine System 1,081 | 18,512
Urinary Tract 1,081 | 18,444
Cardiovascular System 1,080 | 17,958
Liver and Pancreas 1,078 | 18,136
Skin and soft tissues 1,077 | 18,115
Respiratory system 1,072 | 17,484

Target Family

Non-IDG 630 | 11,971
Enzyme 234 | 4,146
Transcription Factor 70 | 1,400
Kinase 47 | 634
Transporter 37 | 473
Ion Channel 32 | 341
GPCR 20 | 406
Epigenetic 17 | 242
Nuclear Receptor 5 | 48
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Transmembrane protein 229B TMEM229B Tdark Non-IDG 1.34 0.03 3
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
ATP-binding cassette sub-family A member 2 ABCA2 Tbio Transporter -1.41708 32.2 125