Development Level

Tbio 250 | 11,651
Tdark 62 | 6,593
Tchem 34 | 1,388
Tclin 11 | 612

Collection

RFA-RM-18-021 8 | 328
Kinase: IDG Consortium (Target... 4 | 125
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99
GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 15 | 979
preweaning lethality, incomple... 14 | 499
enlarged heart 9 | 210
abnormal behavior 8 | 298
decreased total body fat amoun... 6 | 207
decreased vertical activity 6 | 208
abnormal heart morphology 5 | 162
abnormal kidney morphology 5 | 65
decreased lean body mass 5 | 135
hyperactivity 5 | 148
small testis 5 | 58
abnormal behavioral response t... 4 | 66
abnormal embryo size 4 | 220
abnormal eye morphology 4 | 68
abnormal testis morphology 4 | 43
decreased body weight 4 | 161
embryonic lethality prior to t... 4 | 278
male infertility 4 | 123
prenatal lethality prior to he... 4 | 87
abnormal bone structure 3 | 187
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased grip strength 3 | 116
decreased mean corpuscular hem... 3 | 50
embryonic lethality prior to o... 3 | 239
increased blood urea nitrogen ... 3 | 48
increased mean corpuscular vol... 3 | 92
increased total body fat amoun... 3 | 134
small kidney 3 | 16
thrombocytopenia 3 | 56
abnormal cornea morphology 2 | 31
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal epididymis morphology 2 | 42
abnormal eye pigmentation 2 | 3
abnormal facial morphology 2 | 17
abnormal lens morphology 2 | 81
abnormal sleep behavior 2 | 70
abnormal spleen morphology 2 | 55
abnormal tail morphology 2 | 25
abnormal vibrissa morphology 2 | 25
absent pinna reflex 2 | 23
corneal opacity 2 | 32
corneal vascularization 2 | 6
decreased blood urea nitrogen ... 2 | 51
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating insulin ... 2 | 76
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
edema 2 | 59
embryonic growth retardation 2 | 106
female infertility 2 | 60
impaired glucose tolerance 2 | 75
impaired righting response 2 | 26
increased bone mineral content 2 | 108
small superior vagus ganglion 2 | 74
trunk curl 2 | 16
abnormal ear morphology 1 | 9
abnormal hair growth 1 | 10
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal motor capabilities-co... 1 | 5
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal spine curvature 1 | 9
abnormal tail movements 1 | 12
absent vibrissae 1 | 12
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
enlarged spleen 1 | 41
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
long tibia 1 | 25
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small thymus 1 | 16
thin ventricular wall 1 | 24

Disease

atypical teratoid/rhabdoid tumor 357 | 357
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 354 | 18,159
Digestive Tract 352 | 17,369
Female tissues 352 | 17,400
Nervous System 352 | 16,725
Skin and soft tissues 350 | 17,230
Male tissues 348 | 17,142
Blood and immune system 347 | 16,909
Urinary Tract 347 | 16,678
Liver and Pancreas 345 | 16,750
Respiratory system 345 | 16,393
Cardiovascular System 327 | 15,192

Target Family

Non-IDG 193 | 12,091
Enzyme 85 | 4,145
Transcription Factor 23 | 1,400
Transporter 14 | 473
Kinase 13 | 634
Epigenetic 9 | 242
GPCR 7 | 408
Ion Channel 7 | 344
Nuclear Receptor 4 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Parathymosin PTMS Tbio Non-IDG -1.95003 86.3 141
Inactive serine protease PAMR1 PAMR1 Tdark Enzyme -0.86262 5.98 22
Beta-1,3-galactosyltransferase 6 B3GALT6 Tbio Enzyme -1.00350 10.1 132
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L TAF6L Tdark Enzyme 0.55 0.23 173
THUMP domain-containing protein 3 THUMPD3 Tdark Non-IDG 0.48 0.20 97
ADP-sugar pyrophosphatase NUDT5 Tbio Enzyme -1.49012 32.8 61
Protein inturned INTU Tbio Non-IDG -1.76006 53.9 56
Serine/threonine-protein phosphatase 4 regulatory subunit 2 PPP4R2 Tbio Enzyme -0.78829 5.38 130
Protein fosB FOSB Tbio Transcription Factor -2.66286 432.2 328
Sodium/myo-inositol cotransporter 2 SLC5A11 Tchem Transporter -1.76250 46.1 82