Development Level

Tbio 823 | 11,651
Tchem 144 | 1,388
Tdark 124 | 6,593
Tclin 55 | 612

Collection

RFA-RM-18-021 13 | 328
GPCR: IDG Consortium (Targets) 5 | 126
Kinase: IDG Consortium (Target... 5 | 125
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 78 | 979
preweaning lethality, incomple... 37 | 499
decreased total body fat amoun... 30 | 207
increased lean body mass 24 | 172
embryonic lethality prior to o... 23 | 239
abnormal embryo size 22 | 220
embryonic lethality prior to t... 21 | 278
abnormal behavior 16 | 298
decreased lean body mass 16 | 135
abnormal bone structure 15 | 187
decreased body weight 15 | 161
decreased bone mineral content 14 | 151
decreased vertical activity 12 | 208
enlarged heart 12 | 210
increased bone mineral content 12 | 108
embryonic growth retardation 11 | 106
decreased body length 10 | 101
decreased bone mineral density 10 | 126
decreased circulating serum al... 10 | 82
decreased grip strength 10 | 116
decreased mean corpuscular vol... 10 | 79
hyperactivity 10 | 148
increased total body fat amoun... 10 | 134
abnormal heart morphology 9 | 162
decreased circulating choleste... 9 | 93
decreased circulating glucose ... 9 | 126
decreased mean corpuscular hem... 9 | 50
increased bone mineral density 9 | 72
increased fasted circulating g... 9 | 76
increased mean corpuscular vol... 9 | 92
increased startle reflex 9 | 112
decreased startle reflex 8 | 75
hypoactivity 8 | 132
male infertility 8 | 123
short tibia 8 | 97
thrombocytopenia 8 | 56
abnormal coat-hair pigmentatio... 7 | 64
abnormal lens morphology 7 | 81
abnormal neural tube closure 7 | 46
cataract 7 | 92
decreased circulating HDL chol... 7 | 68
decreased circulating total pr... 7 | 49
decreased leukocyte cell numbe... 7 | 73
female infertility 7 | 60
pallor 7 | 34
abnormal bone mineralization 6 | 38
abnormal craniofacial morpholo... 6 | 33
abnormal gait 6 | 69
abnormal retina morphology 6 | 71
abnormal seminal vesicle morph... 6 | 114
abnormal tooth morphology 6 | 24
decreased circulating insulin ... 6 | 76
decreased erythrocyte cell num... 6 | 62
decreased fasted circulating g... 6 | 65
decreased hemoglobin content 6 | 68
increased circulating alkaline... 6 | 122
increased heart weight 6 | 62
increased mean corpuscular hem... 6 | 96
prenatal lethality prior to he... 6 | 87
abnormal kidney morphology 5 | 65
abnormal lung morphology 5 | 26
abnormal placenta size 5 | 20
abnormal sleep behavior 5 | 70
decreased blood urea nitrogen ... 5 | 51
decreased circulating alanine ... 5 | 47
decreased circulating aspartat... 5 | 34
decreased prepulse inhibition 5 | 82
edema 5 | 59
improved glucose tolerance 5 | 79
increased circulating choleste... 5 | 66
increased circulating glycerol... 5 | 9
increased circulating triglyce... 5 | 42
increased mean platelet volume 5 | 45
increased monocyte cell number 5 | 63
microphthalmia 5 | 26
small testis 5 | 58
abnormal eye morphology 4 | 68
abnormal spleen morphology 4 | 55
abnormal testis morphology 4 | 43
anophthalmia 4 | 33
decreased caudal vertebrae num... 4 | 53
decreased circulating alkaline... 4 | 46
decreased circulating calcium ... 4 | 36
decreased circulating triglyce... 4 | 79
decreased hematocrit 4 | 46
decreased lymphocyte cell numb... 4 | 83
decreased neutrophil cell numb... 4 | 42
impaired glucose tolerance 4 | 75
increased circulating HDL chol... 4 | 80
increased circulating chloride... 4 | 41
increased circulating potassiu... 4 | 29
increased mean corpuscular hem... 4 | 36
increased or absent threshold ... 4 | 101
increased red blood cell distr... 4 | 34
pale yolk sac 4 | 25
small adrenal glands 4 | 16
small spleen 4 | 19
abnormal skin coloration 3 | 25
cardiovascular system phenotyp... 3 | 36
increased circulating sodium l... 3 | 71

Disease

astrocytoma 1,146 | 1,146
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Nervous System 1,133 | 16,725
Endocrine System 1,131 | 18,159
Digestive Tract 1,128 | 17,369
Female tissues 1,123 | 17,400
Skin and soft tissues 1,121 | 17,230
Male tissues 1,120 | 17,142
Blood and immune system 1,118 | 16,909
Liver and Pancreas 1,118 | 16,750
Urinary Tract 1,116 | 16,678
Respiratory system 1,109 | 16,393
Cardiovascular System 1,088 | 15,192

Target Family

Non-IDG 672 | 12,091
Enzyme 238 | 4,145
Transcription Factor 79 | 1,400
Kinase 60 | 634
Epigenetic 26 | 242
Transporter 26 | 473
GPCR 20 | 408
Ion Channel 16 | 344
Nuclear Receptor 7 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Gap junction beta-6 protein GJB6 Tbio Non-IDG -2.99235 908.9 170
Protein TANC1 TANC1 Tdark Non-IDG -1.18264 15.5 31
Cysteine-rich with EGF-like domain protein 2 CRELD2 Tbio Non-IDG -0.79330 8.01 176
Glutamate receptor-interacting protein 2 GRIP2 Tdark Non-IDG 0.00000 0
Probable ribonuclease ZC3H12C ZC3H12C Tdark Enzyme -0.40792 1.91 42
RING finger protein unkempt homolog UNK Tbio Non-IDG -2.53936 348.0 64
Transmembrane protein FAM155A FAM155A Tdark Non-IDG 0.19 0.58 69