Development Level

Tbio 1,734 | 11,445
Tdark 502 | 6,588
Tchem 243 | 1,598
Tclin 118 | 613

Collection

RFA-RM-18-021 45 | 328
Ion Channel: IDG Consortium (T... 20 | 99
Kinase: IDG Consortium (Target... 20 | 125
GPCR: IDG Consortium (Targets) 7 | 126
Kinase: IDG Consortium (Comple... 7 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 144 | 979
preweaning lethality, incomple... 99 | 499
abnormal behavior 72 | 298
embryonic lethality prior to t... 47 | 278
decreased total body fat amoun... 44 | 207
abnormal bone structure 41 | 187
abnormal embryo size 40 | 220
hyperactivity 38 | 148
increased lean body mass 32 | 172
decreased vertical activity 31 | 208
embryonic lethality prior to o... 31 | 239
increased circulating alkaline... 29 | 122
decreased bone mineral content 27 | 151
hypoactivity 27 | 132
enlarged heart 26 | 210
decreased lean body mass 24 | 135
increased bone mineral content 24 | 108
increased total body fat amoun... 24 | 134
decreased circulating glucose ... 23 | 126
decreased body weight 22 | 161
decreased circulating choleste... 22 | 93
decreased grip strength 22 | 116
decreased bone mineral density 21 | 126
cataract 20 | 92
decreased lymphocyte cell numb... 20 | 83
increased startle reflex 20 | 112
abnormal heart morphology 19 | 162
abnormal seminal vesicle morph... 19 | 114
decreased startle reflex 18 | 75
embryonic growth retardation 18 | 106
abnormal lens morphology 17 | 81
increased or absent threshold ... 17 | 101
short tibia 17 | 97
abnormal sleep behavior 16 | 70
decreased circulating HDL chol... 16 | 68
decreased prepulse inhibition 16 | 82
edema 16 | 59
male infertility 16 | 123
abnormal gait 15 | 69
decreased hemoglobin content 15 | 68
decreased leukocyte cell numbe... 15 | 73
decreased body length 14 | 101
increased fasted circulating g... 14 | 76
prenatal lethality prior to he... 14 | 87
abnormal eye morphology 13 | 68
abnormal retina morphology 13 | 71
decreased fasted circulating g... 13 | 65
decreased mean corpuscular vol... 13 | 79
improved glucose tolerance 13 | 79
increased blood urea nitrogen ... 13 | 48
increased circulating sodium l... 13 | 71
increased heart weight 13 | 62
increased hematocrit 13 | 46
increased mean corpuscular hem... 13 | 96
increased monocyte cell number 13 | 63
limb grasping 13 | 41
abnormal coat-hair pigmentatio... 12 | 64
decreased circulating serum al... 12 | 82
decreased circulating triglyce... 12 | 79
enlarged lymph nodes 12 | 37
increased bone mineral density 12 | 72
increased circulating chloride... 12 | 41
increased circulating triglyce... 12 | 42
increased leukocyte cell numbe... 12 | 47
increased prepulse inhibition 12 | 32
small superior vagus ganglion 12 | 74
abnormal behavioral response t... 11 | 66
decreased circulating insulin ... 11 | 76
decreased neutrophil cell numb... 11 | 42
increased neutrophil cell numb... 11 | 46
small testis 11 | 58
tremors 11 | 39
abnormal cranium morphology 10 | 36
abnormal kidney morphology 10 | 65
decreased hematocrit 10 | 46
increased mean corpuscular vol... 10 | 92
abnormal epididymis morphology 9 | 42
abnormal skin morphology 9 | 50
abnormal testis morphology 9 | 43
decreased caudal vertebrae num... 9 | 53
decreased circulating calcium ... 9 | 36
decreased erythrocyte cell num... 9 | 62
decreased mean corpuscular hem... 9 | 31
impaired glucose tolerance 9 | 75
increased circulating HDL chol... 9 | 80
increased circulating calcium ... 9 | 34
increased erythrocyte cell num... 9 | 39
abnormal craniofacial morpholo... 8 | 33
absent startle reflex 8 | 24
decreased circulating LDL chol... 8 | 38
decreased mean corpuscular hem... 8 | 50
enlarged spleen 8 | 41
female infertility 8 | 60
increased circulating choleste... 8 | 66
increased circulating creatini... 8 | 38
increased hemoglobin content 8 | 45
increased mean corpuscular hem... 8 | 36
decreased circulating alkaline... 7 | 46
decreased circulating total pr... 7 | 49
enlarged kidney 7 | 14

Disease

astrocytic glioma 2,597 | 2,597
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Nervous System 2,574 | 16,725
Endocrine System 2,568 | 18,159
Digestive Tract 2,540 | 17,369
Female tissues 2,539 | 17,400
Skin and soft tissues 2,530 | 17,230
Male tissues 2,523 | 17,142
Liver and Pancreas 2,489 | 16,750
Urinary Tract 2,489 | 16,678
Blood and immune system 2,477 | 16,909
Respiratory system 2,456 | 16,393
Cardiovascular System 2,352 | 15,192

Target Family

Non-IDG 1,520 | 12,091
Enzyme 576 | 4,145
Transcription Factor 148 | 1,400
Kinase 117 | 634
Ion Channel 72 | 344
Transporter 69 | 473
GPCR 46 | 408
Epigenetic 37 | 242
Nuclear Receptor 8 | 48
TF/Epigenetic 4 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Hexosaminidase D HEXDC Tbio Enzyme -0.60206 3.83 63
Zinc finger protein 160 ZNF160 Tdark Transcription Factor -0.67261 4.33 63
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Protein NipSnap homolog 3B NIPSNAP3B Tbio Non-IDG -1.06487 11.0 103
Protein pelota homolog PELO Tbio Non-IDG -1.33842 18.2 100
Synaptotagmin-like protein 2 SYTL2 Tbio Non-IDG -1.27949 19.5 60