Development Level

Tbio 1,367 | 10,625
Tdark 536 | 7,003
Tchem 244 | 1,890
Tclin 94 | 602

Collection

Eligible Ion Channel Proteins 17 | 117
Eligible Kinase Proteins 17 | 134
Eligible non-olfactory GPCR Proteins 7 | 143

IMPC Term

preweaning lethality, complete... 73 | 633
preweaning lethality, incomple... 45 | 260
abnormal behavior 41 | 226
embryonic lethality prior to t... 31 | 187
decreased lean body mass 29 | 195
decreased total body fat amoun... 29 | 186
increased circulating alkaline... 26 | 119
hyperactivity 25 | 108
decreased body weight 23 | 174
decreased bone mineral content 23 | 157
abnormal bone structure 22 | 131
decreased circulating choleste... 20 | 85
increased lean body mass 20 | 107
abnormal embryo size 19 | 112
decreased circulating HDL chol... 19 | 77
decreased circulating triglyce... 19 | 83
embryonic lethality prior to o... 19 | 148
increased or absent threshold ... 19 | 128
decreased bone mineral density 17 | 126
decreased circulating glucose ... 17 | 121
decreased grip strength 16 | 123
hypoactivity 16 | 89
increased bone mineral content 16 | 92
abnormal retina morphology 15 | 100
increased circulating chloride... 15 | 43
decreased body length 13 | 108
abnormal gait 12 | 51
abnormal sleep behavior 12 | 63
enlarged heart 12 | 111
abnormal lens morphology 11 | 73
increased blood urea nitrogen ... 11 | 44
increased grip strength 11 | 83
decreased leukocyte cell numbe... 10 | 54
decreased prepulse inhibition 10 | 52
increased circulating HDL chol... 10 | 63
male infertility 10 | 62
abnormal coat/hair pigmentatio... 9 | 54
decreased circulating LDL chol... 9 | 37
decreased heart weight 9 | 44
decreased hemoglobin content 9 | 53
increased circulating calcium ... 9 | 32
increased circulating sodium l... 9 | 71
increased fasted circulating g... 9 | 68
increased mean corpuscular hem... 9 | 93
limb grasping 9 | 35
tremors 9 | 34
abnormal retinal pigmentation 8 | 61
cataract 8 | 26
decreased circulating insulin ... 8 | 75
decreased fasted circulating g... 8 | 49
decreased lumbar vertebrae num... 8 | 62
decreased startle reflex 8 | 48
increased hemoglobin content 8 | 45
increased leukocyte cell numbe... 8 | 37
increased mean corpuscular vol... 8 | 91
increased sacral vertebrae num... 8 | 62
increased total body fat amoun... 8 | 57
abnormal bone mineralization 7 | 55
abnormal cranium morphology 7 | 32
abnormal heart morphology 7 | 51
abnormal seminal vesicle morph... 7 | 47
decreased circulating free fat... 7 | 39
decreased circulating serum al... 7 | 79
enlarged lymph nodes 7 | 27
increased exploration in new e... 7 | 56
increased heart weight 7 | 37
increased prepulse inhibition 7 | 21
increased rib number 7 | 41
short tibia 7 | 82
small testis 7 | 37
abnormal behavioral response t... 6 | 52
abnormal testis morphology 6 | 30
abnormal tooth morphology 6 | 24
decreased circulating alanine ... 6 | 53
decreased circulating calcium ... 6 | 33
decreased effector memory CD8-... 6 | 24
decreased eosinophil cell numb... 6 | 41
decreased mean corpuscular vol... 6 | 50
decreased rib number 6 | 59
enlarged spleen 6 | 26
impaired glucose tolerance 6 | 52
increased body weight 6 | 42
increased circulating choleste... 6 | 53
increased circulating creatini... 6 | 29
increased circulating iron lev... 6 | 25
increased circulating phosphat... 6 | 24
increased circulating triglyce... 6 | 24
increased red blood cell distr... 6 | 21
increased startle reflex 6 | 38
prenatal lethality prior to he... 6 | 64
abnormal coat appearance 5 | 25
abnormal epididymis morphology 5 | 31
abnormal locomotor activation 5 | 26
abnormal neural tube closure 5 | 37
cardiovascular system phenotyp... 5 | 35
decreased caudal vertebrae num... 5 | 49
decreased vertical activity 5 | 22
female infertility 5 | 34
improved glucose tolerance 5 | 56
thrombocytosis 5 | 23

Disease

astrocytic glioma 2,241 | 2,241
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Nervous System 2,224 | 18,561
Digestive Tract 2,219 | 18,473
Liver and Pancreas 2,219 | 18,136
Endocrine System 2,218 | 18,512
Female tissues 2,218 | 18,647
Urinary Tract 2,215 | 18,444
Cardiovascular System 2,213 | 17,958
Male tissues 2,211 | 17,969
Skin and soft tissues 2,208 | 18,115
Blood and immune system 2,207 | 17,995
Respiratory system 2,195 | 17,484

Target Family

Non-IDG 1,307 | 11,971
Enzyme 509 | 4,146
Transcription Factor 123 | 1,400
Kinase 97 | 634
Transporter 62 | 473
Ion Channel 61 | 341
GPCR 39 | 406
Epigenetic 31 | 242
Nuclear Receptor 8 | 48
TF/Epigenetic 4 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Monocarboxylate transporter 14 SLC16A14 Tdark Transporter -0.69265 4.88 34
Transmembrane gamma-carboxyglutamic acid protein 3 PRRG3 Tdark Non-IDG -0.21639 1.71 76
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Beta-1,4 N-acetylgalactosaminyltransferase 1 B4GALNT1 Tbio Enzyme -1.85387 67.6 146