Development Level

Tbio 966 | 11,445
Tdark 218 | 6,588
Tchem 186 | 1,598
Tclin 58 | 613

Collection

RFA-RM-18-021 12 | 328
Kinase: IDG Consortium (Target... 5 | 125
GPCR: IDG Consortium (Targets) 4 | 126
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Complete... 2 | 25
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 90 | 979
preweaning lethality, incomple... 50 | 499
abnormal behavior 31 | 298
embryonic lethality prior to t... 30 | 278
abnormal embryo size 27 | 220
enlarged heart 26 | 210
abnormal heart morphology 23 | 162
decreased vertical activity 22 | 208
embryonic lethality prior to o... 21 | 239
cataract 19 | 92
decreased bone mineral content 19 | 151
decreased lean body mass 18 | 135
decreased total body fat amoun... 17 | 207
increased total body fat amoun... 17 | 134
increased lean body mass 16 | 172
hypoactivity 15 | 132
increased mean corpuscular vol... 15 | 92
abnormal bone structure 14 | 187
abnormal seminal vesicle morph... 14 | 114
decreased body weight 14 | 161
increased mean corpuscular hem... 14 | 96
abnormal lens morphology 13 | 81
embryonic growth retardation 13 | 106
hyperactivity 13 | 148
increased circulating alkaline... 12 | 122
decreased circulating glucose ... 11 | 126
decreased mean corpuscular vol... 11 | 79
decreased prepulse inhibition 11 | 82
decreased startle reflex 11 | 75
abnormal retina morphology 10 | 71
decreased circulating choleste... 10 | 93
decreased leukocyte cell numbe... 10 | 73
edema 10 | 59
improved glucose tolerance 10 | 79
increased fasted circulating g... 10 | 76
increased or absent threshold ... 10 | 101
abnormal eye morphology 9 | 68
decreased body length 9 | 101
decreased bone mineral density 9 | 126
decreased circulating HDL chol... 9 | 68
decreased grip strength 9 | 116
decreased hemoglobin content 9 | 68
increased blood urea nitrogen ... 9 | 48
increased circulating HDL chol... 9 | 80
increased startle reflex 9 | 112
abnormal skin morphology 8 | 50
abnormal tail morphology 8 | 25
abnormal tooth morphology 8 | 24
decreased circulating serum al... 8 | 82
decreased erythrocyte cell num... 8 | 62
decreased lymphocyte cell numb... 8 | 83
increased bone mineral density 8 | 72
increased circulating triglyce... 8 | 42
short tibia 8 | 97
abnormal gait 7 | 69
abnormal kidney morphology 7 | 65
abnormal pericardium morpholog... 7 | 26
decreased circulating insulin ... 7 | 76
decreased circulating triglyce... 7 | 79
enlarged spleen 7 | 41
increased grip strength 7 | 41
abnormal behavioral response t... 6 | 66
abnormal spleen morphology 6 | 55
decreased blood urea nitrogen ... 6 | 51
decreased circulating amylase ... 6 | 28
increased bone mineral content 6 | 108
increased circulating choleste... 6 | 66
increased heart rate 6 | 23
increased hematocrit 6 | 46
male infertility 6 | 123
prenatal lethality prior to he... 6 | 87
thrombocytopenia 6 | 56
abnormal bone mineralization 5 | 38
abnormal coat-hair pigmentatio... 5 | 64
abnormal craniofacial morpholo... 5 | 33
abnormal sleep behavior 5 | 70
anophthalmia 5 | 33
decreased circulating alkaline... 5 | 46
decreased circulating calcium ... 5 | 36
decreased circulating creatini... 5 | 39
decreased circulating total pr... 5 | 49
decreased heart weight 5 | 27
decreased red blood cell distr... 5 | 41
decreased threshold for audito... 5 | 26
female infertility 5 | 60
impaired glucose tolerance 5 | 75
increased circulating calcium ... 5 | 34
increased circulating creatini... 5 | 38
increased circulating sodium l... 5 | 71
increased erythrocyte cell num... 5 | 39
increased leukocyte cell numbe... 5 | 47
increased mean corpuscular hem... 5 | 36
increased prepulse inhibition 5 | 32
limb grasping 5 | 41
small superior vagus ganglion 5 | 74
small testis 5 | 58
cardiovascular system phenotyp... 4 | 36
decreased circulating LDL chol... 4 | 38
pale yolk sac 4 | 25
pallor 4 | 34

Disease

adrenocortical carcinoma 1,428 | 1,428
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 1,417 | 18,159
Digestive Tract 1,414 | 17,369
Female tissues 1,412 | 17,400
Male tissues 1,412 | 17,142
Skin and soft tissues 1,410 | 17,230
Liver and Pancreas 1,406 | 16,750
Nervous System 1,406 | 16,725
Urinary Tract 1,406 | 16,678
Respiratory system 1,399 | 16,393
Blood and immune system 1,398 | 16,909
Cardiovascular System 1,363 | 15,192

Target Family

Non-IDG 838 | 12,091
Enzyme 308 | 4,145
Transcription Factor 93 | 1,400
Kinase 71 | 634
Transporter 41 | 473
GPCR 28 | 408
Ion Channel 22 | 344
Epigenetic 15 | 242
Nuclear Receptor 9 | 48
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
Zinc finger protein 160 ZNF160 Tdark Transcription Factor -0.67261 4.33 63
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
MAGE-like protein 2 MAGEL2 Tbio Non-IDG -1.95242 83.8 86
Metastasis-associated protein MTA3 MTA3 Tbio Transcription Factor -1.36174 24.5 204
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
Tropomyosin alpha-4 chain TPM4 Tbio Non-IDG -1.57899 37.4 120
Four and a half LIM domains protein 1 FHL1 Tbio Non-IDG -2.46134 291.4 312
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 DDAH1 Tchem Enzyme -2.13636 144.4 205