Development Level

Tbio 892 | 10,625
Tdark 252 | 7,003
Tchem 226 | 1,890
Tclin 57 | 602

Collection

Eligible Kinase Proteins 5 | 134
Eligible non-olfactory GPCR Proteins 4 | 143
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 68 | 633
preweaning lethality, incomple... 27 | 260
abnormal behavior 23 | 226
decreased lean body mass 22 | 195
embryonic lethality prior to t... 20 | 187
decreased body weight 19 | 174
decreased total body fat amoun... 19 | 186
increased mean corpuscular vol... 19 | 91
decreased bone mineral content 17 | 157
abnormal embryo size 16 | 112
decreased circulating HDL chol... 16 | 77
decreased circulating choleste... 15 | 85
increased circulating alkaline... 15 | 119
increased or absent threshold ... 15 | 128
abnormal lens morphology 14 | 73
enlarged heart 14 | 111
hyperactivity 13 | 108
increased grip strength 13 | 83
increased mean corpuscular hem... 13 | 93
abnormal bone structure 12 | 131
decreased circulating glucose ... 12 | 121
decreased grip strength 12 | 123
embryonic lethality prior to o... 12 | 148
abnormal retina morphology 11 | 100
decreased body length 10 | 108
decreased bone mineral density 10 | 126
decreased hemoglobin content 10 | 53
decreased prepulse inhibition 10 | 52
hypoactivity 10 | 89
increased circulating choleste... 10 | 53
increased fasted circulating g... 10 | 68
increased lean body mass 10 | 107
abnormal retinal pigmentation 9 | 61
increased blood urea nitrogen ... 9 | 44
increased bone mineral content 9 | 92
increased circulating HDL chol... 9 | 63
abnormal tooth morphology 8 | 24
decreased circulating serum al... 8 | 79
decreased circulating triglyce... 8 | 83
decreased leukocyte cell numbe... 8 | 54
decreased mean corpuscular vol... 8 | 50
decreased startle reflex 8 | 48
improved glucose tolerance 8 | 56
increased sacral vertebrae num... 8 | 62
short tibia 8 | 82
abnormal heart morphology 7 | 51
decreased erythrocyte cell num... 7 | 43
increased circulating calcium ... 7 | 32
increased circulating sodium l... 7 | 71
increased circulating triglyce... 7 | 24
increased startle reflex 7 | 38
abnormal coat/hair pigmentatio... 6 | 54
abnormal eye morphology 6 | 38
abnormal gait 6 | 51
abnormal neural tube closure 6 | 37
abnormal seminal vesicle morph... 6 | 47
cardiovascular system phenotyp... 6 | 35
decreased blood urea nitrogen ... 6 | 31
decreased circulating alkaline... 6 | 41
decreased circulating insulin ... 6 | 75
decreased circulating total pr... 6 | 41
decreased heart weight 6 | 44
decreased rib number 6 | 59
increased body weight 6 | 42
increased bone mineral density 6 | 52
increased total body fat amoun... 6 | 57
male infertility 6 | 62
thrombocytopenia 6 | 46
abnormal behavioral response t... 5 | 52
abnormal bone mineralization 5 | 55
abnormal hindbrain development 5 | 24
abnormal skin morphology 5 | 23
abnormal tail morphology 5 | 17
cataract 5 | 26
decreased caudal vertebrae num... 5 | 49
decreased circulating alanine ... 5 | 53
decreased circulating calcium ... 5 | 33
decreased circulating creatini... 5 | 31
decreased lumbar vertebrae num... 5 | 62
decreased vertical activity 5 | 22
female infertility 5 | 34
increased circulating chloride... 5 | 43
increased erythrocyte cell num... 5 | 26
increased heart rate 5 | 17
increased hematocrit 5 | 36
increased hemoglobin content 5 | 45
increased mean corpuscular hem... 5 | 25
increased rib number 5 | 41
limb grasping 5 | 35
polydactyly 5 | 22
prenatal lethality prior to he... 5 | 64
abnormal epididymis morphology 4 | 31
abnormal sleep behavior 4 | 63
anophthalmia 4 | 20
decreased circulating LDL chol... 4 | 37
decreased circulating free fat... 4 | 39
impaired glucose tolerance 4 | 52
increased circulating potassiu... 4 | 31
increased circulating serum al... 4 | 25
increased prepulse inhibition 4 | 21

Disease

adrenocortical carcinoma 1,427 | 1,427
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 1,417 | 18,473
Nervous System 1,417 | 18,561
Female tissues 1,416 | 18,647
Liver and Pancreas 1,416 | 18,136
Male tissues 1,416 | 17,969
Urinary Tract 1,416 | 18,444
Endocrine System 1,415 | 18,512
Cardiovascular System 1,414 | 17,958
Blood and immune system 1,412 | 17,995
Respiratory system 1,412 | 17,484
Skin and soft tissues 1,411 | 18,115

Target Family

Non-IDG 840 | 11,971
Enzyme 307 | 4,146
Transcription Factor 93 | 1,400
Kinase 70 | 634
Transporter 41 | 473
GPCR 28 | 406
Ion Channel 21 | 341
Epigenetic 15 | 242
Nuclear Receptor 9 | 48
TF/Epigenetic 3 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Protein THEMIS2 THEMIS2 Tbio Non-IDG -1.15987 17.5 42
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523