Development Level

Tbio 854 | 11,651
Tdark 148 | 6,593
Tchem 126 | 1,388
Tclin 30 | 612

Collection

RFA-RM-18-021 9 | 328
Kinase: IDG Consortium (Target... 6 | 125
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 80 | 979
preweaning lethality, incomple... 37 | 499
embryonic lethality prior to t... 29 | 278
decreased total body fat amoun... 21 | 207
embryonic lethality prior to o... 21 | 239
abnormal embryo size 20 | 220
abnormal behavior 19 | 298
decreased body weight 17 | 161
enlarged heart 16 | 210
decreased circulating glucose ... 14 | 126
increased lean body mass 13 | 172
abnormal heart morphology 12 | 162
decreased vertical activity 12 | 208
hypoactivity 12 | 132
increased bone mineral content 12 | 108
increased bone mineral density 12 | 72
abnormal bone structure 10 | 187
decreased bone mineral density 10 | 126
decreased lean body mass 10 | 135
increased circulating alkaline... 10 | 122
increased mean corpuscular vol... 10 | 92
decreased bone mineral content 9 | 151
decreased circulating insulin ... 9 | 76
edema 9 | 59
embryonic growth retardation 9 | 106
increased or absent threshold ... 9 | 101
increased startle reflex 9 | 112
short tibia 9 | 97
abnormal retina morphology 8 | 71
abnormal seminal vesicle morph... 8 | 114
decreased lymphocyte cell numb... 8 | 83
prenatal lethality prior to he... 8 | 87
enlarged lymph nodes 7 | 37
abnormal skin morphology 6 | 50
cataract 6 | 92
decreased body length 6 | 101
decreased erythrocyte cell num... 6 | 62
decreased grip strength 6 | 116
decreased leukocyte cell numbe... 6 | 73
decreased prepulse inhibition 6 | 82
enlarged spleen 6 | 41
increased leukocyte cell numbe... 6 | 47
increased monocyte cell number 6 | 63
small superior vagus ganglion 6 | 74
abnormal lens morphology 5 | 81
abnormal spleen morphology 5 | 55
decreased caudal vertebrae num... 5 | 53
decreased circulating HDL chol... 5 | 68
decreased circulating amylase ... 5 | 28
decreased fasted circulating g... 5 | 65
decreased mean corpuscular vol... 5 | 79
decreased neutrophil cell numb... 5 | 42
hyperactivity 5 | 148
increased mean corpuscular hem... 5 | 96
increased total body fat amoun... 5 | 134
abnormal cornea morphology 4 | 31
abnormal epididymis morphology 4 | 42
abnormal joint morphology 4 | 23
abnormal sleep behavior 4 | 70
abnormal tooth morphology 4 | 24
corneal opacity 4 | 32
decreased circulating choleste... 4 | 93
decreased circulating potassiu... 4 | 20
decreased circulating serum al... 4 | 82
decreased circulating triglyce... 4 | 79
decreased heart weight 4 | 27
decreased mean corpuscular hem... 4 | 31
enlarged epididymis 4 | 31
impaired glucose tolerance 4 | 75
improved glucose tolerance 4 | 79
increased blood urea nitrogen ... 4 | 48
increased body weight 4 | 25
increased circulating sodium l... 4 | 71
increased erythrocyte cell num... 4 | 39
increased grip strength 4 | 41
increased hematocrit 4 | 46
increased lymphocyte cell numb... 4 | 32
increased mean platelet volume 4 | 45
persistence of hyaloid vascula... 4 | 33
abnormal bone mineralization 3 | 38
abnormal coat-hair pigmentatio... 3 | 64
abnormal cranium morphology 3 | 36
abnormal skin coloration 3 | 25
absent startle reflex 3 | 24
decreased circulating alkaline... 3 | 46
decreased circulating free fat... 3 | 31
decreased circulating iron lev... 3 | 32
decreased circulating sodium l... 3 | 22
decreased circulating total pr... 3 | 49
decreased red blood cell distr... 3 | 41
hydrometra 3 | 53
increased circulating chloride... 3 | 41
increased fasted circulating g... 3 | 76
increased heart weight 3 | 62
limb grasping 3 | 41
male infertility 3 | 123
pale yolk sac 3 | 25
prenatal lethality 3 | 28
thrombocytosis 3 | 27
tremors 3 | 39

Disease

acute quadriplegic myopathy 1,158 | 1,158
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Skin and soft tissues 1,151 | 17,230
Digestive Tract 1,150 | 17,369
Endocrine System 1,150 | 18,159
Male tissues 1,150 | 17,142
Nervous System 1,143 | 16,725
Blood and immune system 1,142 | 16,909
Female tissues 1,141 | 17,400
Urinary Tract 1,140 | 16,678
Liver and Pancreas 1,137 | 16,750
Cardiovascular System 1,134 | 15,192
Respiratory system 1,130 | 16,393

Target Family

Non-IDG 728 | 12,091
Enzyme 247 | 4,145
Transcription Factor 72 | 1,400
Kinase 46 | 634
Transporter 25 | 473
Epigenetic 21 | 242
Ion Channel 8 | 344
GPCR 6 | 408
Nuclear Receptor 3 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
DBIRD complex subunit ZNF326 ZNF326 Tbio Non-IDG -0.42207 3.94 120
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Eukaryotic translation initiation factor 4E transporter EIF4ENIF1 Tbio Non-IDG -1.60874 36.7 242