Development Level

Tbio 783 | 10,625
Tdark 176 | 7,003
Tchem 168 | 1,890
Tclin 30 | 602

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 51 | 633
decreased total body fat amoun... 23 | 186
decreased lean body mass 19 | 195
embryonic lethality prior to t... 17 | 187
preweaning lethality, incomple... 17 | 260
abnormal behavior 15 | 226
decreased body weight 14 | 174
decreased body length 13 | 108
increased bone mineral content 12 | 92
increased circulating alkaline... 12 | 119
abnormal retina morphology 11 | 100
decreased bone mineral density 11 | 126
abnormal embryo size 10 | 112
embryonic lethality prior to o... 10 | 148
decreased circulating insulin ... 9 | 75
increased lean body mass 9 | 107
increased mean corpuscular hem... 9 | 93
abnormal retinal pigmentation 8 | 61
decreased bone mineral content 8 | 157
decreased circulating glucose ... 8 | 121
decreased grip strength 8 | 123
increased mean corpuscular vol... 8 | 91
increased or absent threshold ... 8 | 128
decreased circulating HDL chol... 7 | 77
decreased heart weight 7 | 44
prenatal lethality prior to he... 7 | 64
short tibia 7 | 82
decreased circulating serum al... 6 | 79
hypoactivity 6 | 89
abnormal bone mineralization 5 | 55
decreased caudal vertebrae num... 5 | 49
decreased erythrocyte cell num... 5 | 43
decreased leukocyte cell numbe... 5 | 54
enlarged heart 5 | 111
enlarged lymph nodes 5 | 27
abnormal bone structure 4 | 131
abnormal lens morphology 4 | 73
abnormal sleep behavior 4 | 63
abnormal tooth morphology 4 | 24
decreased circulating choleste... 4 | 85
decreased circulating free fat... 4 | 39
decreased circulating iron lev... 4 | 25
decreased circulating potassiu... 4 | 17
decreased circulating triglyce... 4 | 83
decreased rib number 4 | 59
enlarged spleen 4 | 26
hydrops fetalis 4 | 22
hyperactivity 4 | 108
improved glucose tolerance 4 | 56
increased blood urea nitrogen ... 4 | 44
increased body weight 4 | 42
increased circulating HDL chol... 4 | 63
increased circulating choleste... 4 | 53
increased circulating sodium l... 4 | 71
increased heart weight 4 | 37
increased leukocyte cell numbe... 4 | 37
shortened ST segment 4 | 9
abnormal coat/hair pigmentatio... 3 | 54
abnormal cornea morphology 3 | 24
abnormal cranium morphology 3 | 32
abnormal skin morphology 3 | 23
decreased CD8-positive, alpha-... 3 | 26
decreased circulating alkaline... 3 | 41
decreased circulating amylase ... 3 | 24
decreased circulating chloride... 3 | 32
decreased circulating fructosa... 3 | 31
decreased circulating total pr... 3 | 41
decreased fasted circulating g... 3 | 49
decreased hemoglobin content 3 | 53
decreased prepulse inhibition 3 | 52
decreased total retina thickne... 3 | 20
increased bone mineral density 3 | 52
increased circulating chloride... 3 | 43
increased circulating potassiu... 3 | 31
increased erythrocyte cell num... 3 | 26
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased heart rate 3 | 17
increased total body fat amoun... 3 | 57
increased vertical activity 3 | 18
straub tail 3 | 26
thrombocytopenia 3 | 46
abnormal behavioral response t... 2 | 52
abnormal epididymis morphology 2 | 31
abnormal gait 2 | 51
abnormal neural tube closure 2 | 37
abnormal spleen morphology 2 | 36
abnormal vocalization 2 | 21
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased neutrophil cell numb... 2 | 37
impaired glucose tolerance 2 | 52
increased circulating bilirubi... 2 | 16
increased circulating total pr... 2 | 20
increased hemoglobin content 2 | 45
increased prepulse inhibition 2 | 21
increased sacral vertebrae num... 2 | 62
persistence of hyaloid vascula... 2 | 22
thrombocytosis 2 | 23
tremors 2 | 34

Disease

acute quadriplegic myopathy 1,157 | 1,157
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Male tissues 1,154 | 17,969
Female tissues 1,153 | 18,647
Liver and Pancreas 1,153 | 18,136
Nervous System 1,153 | 18,561
Blood and immune system 1,152 | 17,995
Cardiovascular System 1,152 | 17,958
Digestive Tract 1,152 | 18,473
Endocrine System 1,152 | 18,512
Urinary Tract 1,150 | 18,444
Respiratory system 1,147 | 17,484
Skin and soft tissues 1,145 | 18,115

Target Family

Non-IDG 727 | 11,971
Enzyme 247 | 4,146
Transcription Factor 72 | 1,400
Kinase 46 | 634
Transporter 25 | 473
Epigenetic 21 | 242
Ion Channel 8 | 341
GPCR 6 | 406
Nuclear Receptor 3 | 48
TF/Epigenetic 2 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Antileukoproteinase SLPI Tbio Enzyme -2.56514 434.2 290
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326