Development Level

Tbio 500 | 11,178
Tdark 134 | 6,569
Tchem 102 | 1,885
Tclin 24 | 612

Collection

Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 2 | 126
Ion Channel: IDG Consortium (T... 2 | 99
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 68 | 979
preweaning lethality, incomple... 38 | 499
embryonic lethality prior to t... 23 | 278
abnormal embryo size 22 | 220
embryonic lethality prior to o... 17 | 239
abnormal behavior 13 | 298
increased startle reflex 12 | 112
hyperactivity 11 | 148
impaired glucose tolerance 11 | 75
decreased bone mineral density 10 | 126
increased lean body mass 10 | 172
decreased bone mineral content 9 | 151
decreased total body fat amoun... 9 | 207
increased total body fat amoun... 9 | 134
abnormal bone structure 8 | 187
embryonic growth retardation 8 | 106
improved glucose tolerance 8 | 79
decreased body weight 7 | 161
increased circulating alkaline... 7 | 122
abnormal heart morphology 6 | 162
abnormal neural tube closure 6 | 46
decreased erythrocyte cell num... 6 | 62
decreased mean corpuscular vol... 6 | 79
enlarged heart 6 | 210
hypoactivity 6 | 132
increased bone mineral density 6 | 72
abnormal craniofacial morpholo... 5 | 33
abnormal lens morphology 5 | 81
decreased circulating HDL chol... 5 | 68
decreased circulating serum al... 5 | 82
decreased lean body mass 5 | 135
decreased lymphocyte cell numb... 5 | 83
decreased startle reflex 5 | 75
edema 5 | 59
increased bone mineral content 5 | 108
increased circulating HDL chol... 5 | 80
increased circulating choleste... 5 | 66
increased heart weight 5 | 62
increased mean corpuscular hem... 5 | 96
increased mean corpuscular vol... 5 | 92
male infertility 5 | 123
microphthalmia 5 | 26
short tibia 5 | 97
abnormal seminal vesicle morph... 4 | 114
abnormal sleep behavior 4 | 70
abnormal spleen morphology 4 | 55
cataract 4 | 92
decreased body length 4 | 101
decreased circulating chloride... 4 | 30
decreased circulating choleste... 4 | 93
decreased grip strength 4 | 116
decreased hemoglobin content 4 | 68
decreased prepulse inhibition 4 | 82
decreased vertical activity 4 | 208
female infertility 4 | 60
increased erythrocyte cell num... 4 | 39
increased hematocrit 4 | 46
increased monocyte cell number 4 | 63
prenatal lethality 4 | 28
prenatal lethality prior to he... 4 | 87
small superior vagus ganglion 4 | 74
abnormal coat appearance 3 | 31
abnormal coat-hair pigmentatio... 3 | 64
abnormal cornea morphology 3 | 31
abnormal eye morphology 3 | 68
abnormal forebrain development 3 | 20
abnormal retina morphology 3 | 71
abnormal retinal vasculature m... 3 | 27
anophthalmia 3 | 33
decreased blood urea nitrogen ... 3 | 51
decreased circulating LDL chol... 3 | 38
decreased circulating creatini... 3 | 39
decreased circulating sodium l... 3 | 22
decreased circulating total pr... 3 | 49
decreased heart weight 3 | 27
decreased hematocrit 3 | 46
decreased leukocyte cell numbe... 3 | 73
decreased neutrophil cell numb... 3 | 42
enlarged spleen 3 | 41
impaired righting response 3 | 26
increased blood urea nitrogen ... 3 | 48
increased circulating chloride... 3 | 41
increased circulating iron lev... 3 | 30
increased fasted circulating g... 3 | 76
increased hemoglobin content 3 | 45
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 36
increased mean platelet volume 3 | 45
increased neutrophil cell numb... 3 | 46
increased or absent threshold ... 3 | 101
increased prepulse inhibition 3 | 32
limb grasping 3 | 41
pallor 3 | 34
tremors 3 | 39
trunk curl 3 | 16
vertebral transformation 3 | 12
abnormal skin coloration 2 | 25
decreased fasted circulating g... 2 | 65
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 28

Disease

acute myeloid leukemia 760 | 760
Carcinoma 11,192 | 11,192
ovarian cancer 8,297 | 8,297
osteosarcoma 7,766 | 7,766
psoriasis 6,514 | 6,514
medulloblastoma, large-cell 6,086 | 6,086
glioblastoma 5,635 | 5,635
atypical teratoid / rhabdoid tumor 4,971 | 4,971
lung cancer 4,607 | 4,607
ependymoma 4,559 | 4,559
group 3 medulloblastoma 4,002 | 4,002
adult high grade glioma 3,701 | 3,701
Breast cancer 3,469 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,204 | 3,204
malignant mesothelioma 3,135 | 3,135
Astrocytoma, Pilocytic 3,006 | 3,006
primitive neuroectodermal tumor 2,957 | 2,957
intraductal papillary-mucinous carcinoma (IPMC) 2,902 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,872 | 2,872
invasive ductal carcinoma 2,867 | 2,867
non-small cell lung cancer 2,799 | 2,799
oligodendroglioma 2,768 | 2,768
lung carcinoma 2,755 | 2,755
lung adenocarcinoma 2,627 | 2,627
Kidney cancer 2,548 | 2,548
astrocytic glioma 2,530 | 2,530
Cancer 2,388 | 2,388
pancreatic cancer 2,322 | 2,322
interstitial cystitis 2,237 | 2,237
subependymal giant cell astrocytoma 2,230 | 2,230
tuberculosis 1,963 | 1,963
pituitary cancer 1,915 | 1,915
pancreatic ductal adenocarcinoma liver metastasis 1,911 | 1,911
Pick disease 1,856 | 1,856
group 4 medulloblastoma 1,806 | 1,806
ulcerative colitis 1,765 | 1,765
ductal carcinoma in situ 1,686 | 1,686
diabetes mellitus 1,683 | 1,683
cystic fibrosis 1,629 | 1,629
breast carcinoma 1,589 | 1,589
colon cancer 1,428 | 1,428
Autosomal recessive predisposition 1,407 | 1,407
adrenocortical carcinoma 1,385 | 1,385
Multiple myeloma 1,296 | 1,296
Rheumatoid arthritis 1,156 | 1,156
juvenile dermatomyositis 1,147 | 1,147
Schizophrenia 1,136 | 1,136
acute quadriplegic myopathy 1,133 | 1,133
astrocytoma 1,113 | 1,113
primary pancreatic ductal adenocarcinoma 1,071 | 1,071
spina bifida 1,053 | 1,053
pediatric high grade glioma 1,035 | 1,035
nasopharyngeal carcinoma 1,024 | 1,024
cutaneous lupus erythematosus 1,016 | 1,016
Intellectual disability 998 | 998
dermatomyositis 941 | 941
Atopic dermatitis 915 | 915
active Crohn's disease 882 | 882
non primary Sjogren syndrome sicca 861 | 861
gastric carcinoma 781 | 781
Epilepsy 775 | 775
Waldenstrons macroglobulinemia 742 | 742
active ulcerative colitis 736 | 736
Liver Cirrhosis, Experimental 733 | 733
primary Sjogren syndrome 710 | 710
medulloblastoma 702 | 702
esophageal adenocarcinoma 696 | 696
Melanoma 689 | 689
progressive supranuclear palsy 656 | 656
Obesity 655 | 655
Bipolar Disorder 646 | 646
aldosterone-producing adenoma 646 | 646
Alzheimer's disease 640 | 640
Dull intelligence 634 | 634
Low intelligence 634 | 634
Mental Retardation 634 | 634
Mental deficiency 634 | 634
Poor school performance 634 | 634
Cognitive delay 596 | 596
Global developmental delay 596 | 596
Mental and motor retardation 596 | 596
Liver cancer 589 | 589
Duchenne muscular dystrophy 587 | 587
Seizures 584 | 584
Muscle hypotonia 562 | 562
pancreatic carcinoma 555 | 555
fibroadenoma 538 | 538
hepatocellular carcinoma 536 | 536
Multiple Sclerosis 527 | 527
Endometriosis 521 | 521
Short stature 514 | 514
chronic rhinosinusitis 505 | 505
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 492
Down syndrome 480 | 480
mucosa-associated lymphoid tissue lymphoma 473 | 473
Prostatic Neoplasms 472 | 472
sonic hedgehog group medulloblastoma 459 | 459
posterior fossa group A ependymoma 456 | 456
Skin cancer 451 | 451
gastric cancer 445 | 445

Tissue

Blood and immune system 758 | 16,909
Digestive Tract 758 | 17,369
Endocrine System 758 | 18,159
Female tissues 757 | 17,400
Liver and Pancreas 756 | 16,750
Respiratory system 756 | 16,393
Skin and soft tissues 755 | 17,230
Male tissues 754 | 17,142
Urinary Tract 753 | 16,678
Nervous System 750 | 16,725
Cardiovascular System 741 | 15,192

Target Family

Non-IDG 426 | 12,091
Enzyme 183 | 4,145
Transcription Factor 66 | 1,400
Kinase 30 | 634
Transporter 16 | 473
Epigenetic 13 | 242
GPCR 12 | 408
TF/Epigenetic 8 | 38
Ion Channel 5 | 344
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RNA-binding protein 20 RBM20 Tbio Non-IDG -1.40778 24.2 73
Diphosphoinositol polyphosphate phosphohydrolase 3-beta NUDT11 Tdark Enzyme -0.57393 3.94 17
Bcl-2 homologous antagonist/killer BAK1 Tchem Non-IDG -2.29199 175.9 554
Copper-transporting ATPase 1 ATP7A Tbio Enzyme -3.08069 1155.0 263
Histone-lysine N-methyltransferase 2A KMT2A Tchem Epigenetic -2.88228 736.0 334
E3 ubiquitin-protein ligase TRIM38 TRIM38 Tbio Enzyme -0.76476 6.14 346
Zinc finger protein 486 ZNF486 Tdark Transcription Factor 0.00000 60
Pirin PIR Tchem Non-IDG -2.72312 503.8 154
KAT8 regulatory NSL complex subunit 2 KANSL2 Tbio Non-IDG -0.72700 5.47 32
Diamine acetyltransferase 1 SAT1 Tbio Enzyme -2.60045 409.5 159