Development Level

Tbio 499 | 10,625
Tdark 154 | 7,003
Tchem 106 | 1,890
Tclin 26 | 602

Collection

Eligible Ion Channel Proteins 2 | 117
Eligible Kinase Proteins 2 | 134
Eligible non-olfactory GPCR Proteins 2 | 145

IMPC Term

preweaning lethality, complete... 48 | 633
preweaning lethality, incomple... 19 | 260
embryonic lethality prior to t... 17 | 187
decreased bone mineral density 14 | 126
embryonic lethality prior to o... 14 | 148
decreased lean body mass 13 | 195
increased circulating alkaline... 12 | 119
abnormal behavior 11 | 226
abnormal embryo size 10 | 112
decreased bone mineral content 10 | 157
decreased body length 9 | 108
abnormal retina morphology 8 | 100
decreased body weight 8 | 174
decreased lumbar vertebrae num... 8 | 62
decreased total body fat amoun... 8 | 186
abnormal retinal pigmentation 7 | 61
hyperactivity 7 | 108
abnormal bone structure 6 | 131
impaired glucose tolerance 6 | 52
increased grip strength 6 | 83
increased mean corpuscular vol... 6 | 91
increased sacral vertebrae num... 6 | 62
decreased circulating HDL chol... 5 | 77
increased lean body mass 5 | 107
increased mean corpuscular hem... 5 | 93
increased startle reflex 5 | 38
prenatal lethality prior to he... 5 | 64
short tibia 5 | 82
abnormal heart morphology 4 | 51
abnormal lens morphology 4 | 73
abnormal neural tube closure 4 | 37
abnormal sleep behavior 4 | 63
decreased circulating LDL chol... 4 | 37
decreased circulating choleste... 4 | 85
decreased circulating serum al... 4 | 79
decreased effector memory CD8-... 4 | 24
decreased erythrocyte cell num... 4 | 43
decreased leukocyte cell numbe... 4 | 54
embryonic growth retardation 4 | 28
enlarged heart 4 | 111
hypoactivity 4 | 89
increased bone mineral content 4 | 92
increased circulating choleste... 4 | 53
increased or absent threshold ... 4 | 128
microphthalmia 4 | 15
vertebral transformation 4 | 12
abnormal bone mineralization 3 | 55
abnormal coat appearance 3 | 25
abnormal coat/hair pigmentatio... 3 | 54
abnormal craniofacial morpholo... 3 | 12
abnormal eye morphology 3 | 38
abnormal rib morphology 3 | 28
abnormal vocalization 3 | 21
decreased circulating calcium ... 3 | 33
decreased circulating creatini... 3 | 31
decreased circulating glucose ... 3 | 121
decreased circulating total pr... 3 | 41
decreased grip strength 3 | 123
decreased hemoglobin content 3 | 53
decreased monocyte cell number 3 | 28
decreased neutrophil cell numb... 3 | 37
decreased prepulse inhibition 3 | 52
decreased spleen weight 3 | 13
decreased startle reflex 3 | 48
improved glucose tolerance 3 | 56
increased circulating HDL chol... 3 | 63
increased circulating calcium ... 3 | 32
increased circulating chloride... 3 | 43
increased erythrocyte cell num... 3 | 26
increased exploration in new e... 3 | 56
increased fasted circulating g... 3 | 68
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
increased total body fat amoun... 3 | 57
male infertility 3 | 62
polydactyly 3 | 22
thrombocytopenia 3 | 46
tremors 3 | 34
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal neural tube morpholog... 2 | 8
abnormal spleen morphology 2 | 36
anophthalmia 2 | 20
decreased Ly6C high monocyte n... 2 | 18
decreased caudal vertebrae num... 2 | 49
decreased circulating iron lev... 2 | 25
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
female infertility 2 | 34
increased circulating fructosa... 2 | 11
increased circulating iron lev... 2 | 25
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 20
increased heart weight 2 | 37
vertebral fusion 2 | 23

Disease

acute myeloid leukemia 785 | 785
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 781 | 17,995
Digestive Tract 781 | 18,473
Male tissues 781 | 17,969
Urinary Tract 781 | 18,444
Endocrine System 780 | 18,512
Female tissues 780 | 18,647
Nervous System 780 | 18,561
Liver and Pancreas 779 | 18,136
Cardiovascular System 776 | 17,958
Respiratory system 774 | 17,484
Skin and soft tissues 774 | 18,115

Target Family

Non-IDG 430 | 11,969
Enzyme 196 | 4,146
Transcription Factor 73 | 1,400
Kinase 29 | 634
Transporter 17 | 473
Epigenetic 14 | 242
GPCR 12 | 408
TF/Epigenetic 8 | 38
Ion Channel 5 | 341
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bromodomain adjacent to zinc finger domain protein 2A BAZ2A Tchem TF/Epigenetic -2.05410 110.9 33
Ubiquinol-cytochrome-c reductase complex assembly factor 2 UQCC2 Tbio Enzyme -1.50813 29.9 15
Protein C-ets-2 ETS2 Tbio Transcription Factor -2.39443 244.9 192
Programmed cell death protein 2-like PDCD2L Tbio Non-IDG -0.34430 2.55 117
Unconventional myosin-Va MYO5A Tbio Non-IDG -1.72093 48.8 66
DnaJ homolog subfamily C member 17 DNAJC17 Tdark Non-IDG -0.04079 1.12 105
HBS1-like protein HBS1L Tbio Non-IDG -2.52098 316.2 144
Proteasomal ATPase-associated factor 1 PAAF1 Tbio Enzyme -1.63557 41.8 63
Short-chain dehydrogenase/reductase family 42E member 1 SDR42E1 Tdark Enzyme 0.00000 11
Zinc finger protein 711 ZNF711 Tdark Transcription Factor -0.77910 5.17 33