Development Level

Tbio 496 | 10,625
Tdark 154 | 7,003
Tchem 104 | 1,890
Tclin 26 | 602

Collection

Eligible Ion Channel Proteins 2 | 117
Eligible Kinase Proteins 2 | 134
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 48 | 633
preweaning lethality, incomple... 19 | 260
embryonic lethality prior to t... 17 | 187
embryonic lethality prior to o... 14 | 148
decreased bone mineral density 13 | 126
decreased lean body mass 13 | 195
increased circulating alkaline... 12 | 119
abnormal behavior 11 | 226
abnormal embryo size 10 | 112
decreased bone mineral content 10 | 157
decreased body length 9 | 108
abnormal retina morphology 8 | 100
decreased body weight 8 | 174
decreased lumbar vertebrae num... 8 | 62
abnormal retinal pigmentation 7 | 61
decreased total body fat amoun... 7 | 186
hyperactivity 7 | 108
abnormal bone structure 6 | 131
impaired glucose tolerance 6 | 52
increased grip strength 6 | 83
increased mean corpuscular vol... 6 | 91
increased sacral vertebrae num... 6 | 62
decreased circulating HDL chol... 5 | 77
increased mean corpuscular hem... 5 | 93
increased startle reflex 5 | 38
prenatal lethality prior to he... 5 | 64
short tibia 5 | 82
abnormal heart morphology 4 | 51
abnormal lens morphology 4 | 73
abnormal neural tube closure 4 | 37
abnormal sleep behavior 4 | 63
decreased circulating LDL chol... 4 | 37
decreased circulating choleste... 4 | 85
decreased circulating serum al... 4 | 79
decreased effector memory CD8-... 4 | 24
decreased erythrocyte cell num... 4 | 43
decreased leukocyte cell numbe... 4 | 54
embryonic growth retardation 4 | 28
enlarged heart 4 | 111
hypoactivity 4 | 89
increased bone mineral content 4 | 92
increased circulating choleste... 4 | 53
increased lean body mass 4 | 107
increased or absent threshold ... 4 | 128
microphthalmia 4 | 15
vertebral transformation 4 | 12
abnormal bone mineralization 3 | 55
abnormal coat appearance 3 | 25
abnormal coat/hair pigmentatio... 3 | 54
abnormal craniofacial morpholo... 3 | 12
abnormal eye morphology 3 | 38
abnormal rib morphology 3 | 28
abnormal vocalization 3 | 21
decreased circulating calcium ... 3 | 33
decreased circulating creatini... 3 | 31
decreased circulating glucose ... 3 | 121
decreased circulating total pr... 3 | 41
decreased grip strength 3 | 123
decreased hemoglobin content 3 | 53
decreased monocyte cell number 3 | 28
decreased neutrophil cell numb... 3 | 37
decreased prepulse inhibition 3 | 52
decreased spleen weight 3 | 13
decreased startle reflex 3 | 48
improved glucose tolerance 3 | 56
increased circulating HDL chol... 3 | 63
increased circulating calcium ... 3 | 32
increased circulating chloride... 3 | 43
increased erythrocyte cell num... 3 | 26
increased exploration in new e... 3 | 56
increased fasted circulating g... 3 | 68
increased hematocrit 3 | 36
increased hemoglobin content 3 | 45
increased total body fat amoun... 3 | 57
male infertility 3 | 62
polydactyly 3 | 22
thrombocytopenia 3 | 46
tremors 3 | 34
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal neural tube morpholog... 2 | 8
abnormal spleen morphology 2 | 36
anophthalmia 2 | 20
decreased Ly6C high monocyte n... 2 | 18
decreased caudal vertebrae num... 2 | 49
decreased circulating iron lev... 2 | 25
decreased fasted circulating g... 2 | 49
decreased heart weight 2 | 44
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
female infertility 2 | 34
increased circulating fructosa... 2 | 11
increased circulating iron lev... 2 | 25
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 20
increased heart weight 2 | 37
vertebral fusion 2 | 23

Disease

acute myeloid leukemia 780 | 780
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Blood and immune system 776 | 17,995
Digestive Tract 776 | 18,473
Male tissues 776 | 17,969
Urinary Tract 776 | 18,444
Endocrine System 775 | 18,512
Female tissues 775 | 18,647
Nervous System 775 | 18,561
Liver and Pancreas 774 | 18,136
Cardiovascular System 771 | 17,958
Respiratory system 769 | 17,484
Skin and soft tissues 769 | 18,115

Target Family

Non-IDG 430 | 11,971
Enzyme 196 | 4,146
Transcription Factor 69 | 1,400
Kinase 29 | 634
Transporter 17 | 473
Epigenetic 13 | 242
GPCR 12 | 406
TF/Epigenetic 8 | 38
Ion Channel 5 | 341
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Monocarboxylate transporter 14 SLC16A14 Tdark Transporter -0.69265 4.88 34
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Natural killer cell receptor 2B4 CD244 Tbio Non-IDG -2.27438 190.1 418
Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 Tchem Enzyme -2.37851 255.2 269
mRNA decay activator protein ZFP36 ZFP36 Tbio Non-IDG -2.38153 220.3 0
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Interleukin enhancer-binding factor 2 ILF2 Tbio Non-IDG -1.51960 36.4 249