Development Level

Tbio 603 | 10,625
Tdark 154 | 7,003
Tchem 136 | 1,890
Tclin 25 | 602

Collection

Ion Channel: IDG Consortium (Targets) 7 | 102
GPCR: IDG Consortium (Complete/Control) 2 | 26
GPCR: IDG Consortium (Targets) 2 | 127
Kinase: IDG Consortium (Complete/Control) 1 | 37
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 22 | 633
decreased lean body mass 14 | 195
preweaning lethality, incomple... 13 | 260
decreased bone mineral content 10 | 157
decreased total body fat amoun... 10 | 186
increased circulating alkaline... 9 | 119
increased or absent threshold ... 9 | 128
decreased body weight 8 | 174
decreased circulating glucose ... 8 | 121
increased grip strength 8 | 83
increased total body fat amoun... 8 | 57
abnormal behavior 7 | 226
decreased circulating insulin ... 7 | 75
abnormal lens morphology 6 | 73
decreased body length 6 | 108
decreased bone mineral density 6 | 126
thrombocytopenia 6 | 46
decreased mean corpuscular hem... 5 | 34
decreased mean corpuscular vol... 5 | 50
enlarged heart 5 | 111
increased exploration in new e... 5 | 56
increased lean body mass 5 | 107
short tibia 5 | 82
abnormal bone structure 4 | 131
decreased Ly6C low monocyte nu... 4 | 23
decreased circulating HDL chol... 4 | 77
decreased circulating alkaline... 4 | 41
decreased erythrocyte cell num... 4 | 43
decreased grip strength 4 | 123
decreased monocyte cell number 4 | 28
decreased rib number 4 | 59
improved glucose tolerance 4 | 56
increased blood urea nitrogen ... 4 | 44
increased bone mineral content 4 | 92
increased circulating HDL chol... 4 | 63
increased circulating choleste... 4 | 53
increased circulating phosphat... 4 | 24
prenatal lethality prior to he... 4 | 64
abnormal coping response 3 | 12
abnormal femur morphology 3 | 14
abnormal heart morphology 3 | 51
abnormal retina morphology 3 | 100
abnormal testis morphology 3 | 30
cataract 3 | 26
decreased KLRG1-positive NK ce... 3 | 9
decreased NK cell number 3 | 16
decreased caudal vertebrae num... 3 | 49
decreased circulating serum al... 3 | 79
decreased startle reflex 3 | 48
female infertility 3 | 34
hyperactivity 3 | 108
impaired glucose tolerance 3 | 52
increased B cell number 3 | 23
increased Ly6C high monocyte n... 3 | 12
increased T cell number 3 | 15
increased body weight 3 | 42
increased bone mineral density 3 | 52
increased circulating sodium l... 3 | 71
increased circulating triglyce... 3 | 24
increased fasted circulating g... 3 | 68
increased neutrophil cell numb... 3 | 15
increased rib number 3 | 41
male infertility 3 | 62
small superior vagus ganglion 3 | 20
small testis 3 | 37
tremors 3 | 34
abnormal cranium morphology 2 | 32
abnormal embryo size 2 | 112
abnormal epididymis morphology 2 | 31
abnormal heart left ventricle ... 2 | 20
abnormal lung morphology 2 | 15
abnormal retinal pigmentation 2 | 61
abnormal sleep behavior 2 | 63
abnormal spleen morphology 2 | 36
abnormal startle reflex 2 | 14
decreased T cell number 2 | 31
decreased blood urea nitrogen ... 2 | 31
decreased circulating chloride... 2 | 32
decreased circulating triglyce... 2 | 83
decreased effector memory CD8-... 2 | 24
decreased fasted circulating g... 2 | 49
decreased gamma-delta T cell n... 2 | 18
decreased heart weight 2 | 44
decreased hemoglobin content 2 | 53
decreased lumbar vertebrae num... 2 | 62
embryonic lethality prior to t... 2 | 187
increased NK T cell number 2 | 11
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating creatini... 2 | 29
increased circulating magnesiu... 2 | 10
increased eosinophil cell numb... 2 | 9
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 91
increased prepulse inhibition 2 | 21
increased sacral vertebrae num... 2 | 62
limb grasping 2 | 35
long tibia 2 | 13
prenatal lethality 2 | 16

Disease

active Crohn's disease 918 | 918
ovarian cancer 8,491 | 8,491
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,098 | 3,098
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,170 | 1,170
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 966 | 966
Atopic dermatitis 944 | 944
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 788 | 788
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 764 | 764
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 334 | 334
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 910 | 18,472
Liver and Pancreas 908 | 18,135
Urinary Tract 907 | 18,443
Endocrine System 906 | 18,511
Female tissues 906 | 18,646
Nervous System 906 | 18,560
Blood and immune system 905 | 17,994
Male tissues 903 | 17,968
Cardiovascular System 899 | 17,957
Respiratory system 897 | 17,483
Skin and soft tissues 896 | 18,114

Target Family

Non-IDG 502 | 11,969
Enzyme 253 | 4,146
Transporter 54 | 473
Transcription Factor 46 | 1,400
Kinase 22 | 634
Ion Channel 20 | 341
GPCR 12 | 408
Epigenetic 6 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.69372 46.6 95
Sorting nexin-32 SNX32 Tdark Non-IDG 0.60 0.07 75
Thyrotropin-releasing hormone-degrading ectoenzyme TRHDE Tdark Enzyme -1.61185 36.9 43
Interferon-induced transmembrane protein 3 IFITM3 Tbio Non-IDG -1.87958 126.0 172
Interferon-induced transmembrane protein 2 IFITM2 Tbio Non-IDG -2.21851 158.1 111
Chitobiosyldiphosphodolichol beta-mannosyltransferase ALG1 Tbio Enzyme -1.71423 54.0 77
SEC14 domain and spectrin repeat-containing protein 1 SESTD1 Tbio Non-IDG -0.65079 5.02 55
Alternative prion protein PRNP Tbio Non-IDG -3.44085 5471.9 0
Serine protease hepsin HPN Tchem Enzyme -2.46640 312.3 106
Guanylate-binding protein 4 GBP4 Tbio Non-IDG -1.67376 45.5 102