1. Home
  2. Targets
Target Filters...

Development Level

Tbio 87 | 11,445
Tdark 14 | 6,588
Tchem 11 | 1,598
Tclin 4 | 613

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal behavior 5 | 298
decreased fasted circulating g... 3 | 65
decreased vertical activity 3 | 208
hypoactivity 3 | 132
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
decreased erythrocyte cell num... 2 | 62
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
impaired righting response 2 | 26
increased bone mineral content 2 | 108
increased circulating creatini... 2 | 38
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal placement of pupils 1 | 6
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal scapula morphology 1 | 3
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
embryonic lethality prior to o... 1 | 239
female infertility 1 | 60
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased basophil cell number 1 | 7
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased eosinophil cell numb... 1 | 11
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
syndactyly 1 | 23

Disease

X-linked cerebral adrenoleukodystrophy 116 | 116
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Blood and immune system 116 | 16,909
Digestive Tract 116 | 17,369
Endocrine System 116 | 18,159
Female tissues 116 | 17,400
Respiratory system 116 | 16,393
Skin and soft tissues 116 | 17,230
Liver and Pancreas 115 | 16,750
Male tissues 115 | 17,142
Urinary Tract 115 | 16,678
Nervous System 114 | 16,725
Cardiovascular System 112 | 15,192

Target Family

Non-IDG 62 | 12,091
Enzyme 28 | 4,145
Transcription Factor 10 | 1,400
Kinase 5 | 634
Transporter 5 | 473
GPCR 4 | 408
Epigenetic 1 | 242
Ion Channel 1 | 344

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NEDD4-binding protein 2 N4BP2 Tbio Non-IDG -0.54327 3.39 19
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
von Willebrand factor A domain-containing protein 8 VWA8 Tbio Non-IDG -0.36798 2.42 8
Disintegrin and metalloproteinase domain-containing protein 12 ADAM12 Tchem Enzyme -2.28901 214.1 347
Collagen alpha-2(V) chain COL5A2 Tbio Non-IDG -1.69982 44.6 96
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A Tclin Enzyme -1.27429 21.3 169
Potassium voltage-gated channel subfamily G member 1 KCNG1 Tclin Ion Channel -1.83662 59.3 87
Secreted and transmembrane protein 1 SECTM1 Tbio Non-IDG -0.82741 7.99 65
Collagen alpha-1(XII) chain COL12A1 Tbio Non-IDG -1.36571 21.4 38
Monocarboxylate transporter 1 SLC16A1 Tchem Transporter -2.46059 294.2 236