Development Level

Tbio 563 | 10,625
Tchem 124 | 1,890
Tdark 47 | 7,003
Tclin 31 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 48 | 633
embryonic lethality prior to o... 12 | 148
embryonic lethality prior to t... 12 | 187
decreased body weight 10 | 174
preweaning lethality, incomple... 9 | 260
abnormal behavior 8 | 226
decreased total body fat amoun... 8 | 186
hypoactivity 6 | 89
abnormal embryo size 5 | 112
decreased leukocyte cell numbe... 5 | 54
increased mean corpuscular hem... 5 | 93
abnormal bone structure 4 | 131
abnormal lens morphology 4 | 73
abnormal retina morphology 4 | 100
decreased CD4-positive, CD25-p... 4 | 24
decreased circulating alanine ... 4 | 53
decreased circulating serum al... 4 | 79
decreased effector memory CD8-... 4 | 24
decreased lean body mass 4 | 195
hyperactivity 4 | 108
increased body weight 4 | 42
increased grip strength 4 | 83
increased hemoglobin content 4 | 45
increased mean corpuscular hem... 4 | 25
abnormal coat/hair pigmentatio... 3 | 54
decreased bone mineral content 3 | 157
decreased circulating calcium ... 3 | 33
decreased circulating magnesiu... 3 | 11
decreased erythrocyte cell num... 3 | 43
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 19
decreased mean corpuscular vol... 3 | 50
decreased neutrophil cell numb... 3 | 37
decreased total retina thickne... 3 | 20
increased circulating HDL chol... 3 | 63
increased circulating alkaline... 3 | 119
increased circulating sodium l... 3 | 71
increased exploration in new e... 3 | 56
increased heart weight 3 | 37
increased lean body mass 3 | 107
increased prepulse inhibition 3 | 21
thrombocytopenia 3 | 46
abnormal cranium morphology 2 | 32
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal maxilla morphology 2 | 16
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal sleep behavior 2 | 63
abnormal testis morphology 2 | 30
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating iron lev... 2 | 25
decreased circulating potassiu... 2 | 17
decreased circulating sodium l... 2 | 18
decreased grip strength 2 | 123
decreased mean corpuscular hem... 2 | 34
decreased mean platelet volume 2 | 12
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased startle reflex 2 | 48
decreased threshold for audito... 2 | 32
enlarged lymph nodes 2 | 27
immune system phenotype 2 | 17
increased CD4-positive, alpha ... 2 | 15
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating amylase ... 2 | 13
increased circulating choleste... 2 | 53
increased circulating glucose ... 2 | 16
increased fasted circulating g... 2 | 68
increased mean corpuscular vol... 2 | 91
increased neutrophil cell numb... 2 | 15
increased or absent threshold ... 2 | 128
increased rib number 2 | 41
increased sacral vertebrae num... 2 | 62
prenatal lethality prior to he... 2 | 64
shortened RR interval 2 | 19
shortened ST segment 2 | 9
small adrenal glands 2 | 15
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal motor capabilities/co... 1 | 4
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased circulating chloride... 1 | 32
decreased circulating triglyce... 1 | 83
decreased heart weight 1 | 44
increased NK cell number 1 | 19
increased body length 1 | 20

Disease

Waldenstrons macroglobulinemia 765 | 765
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Liver and Pancreas 765 | 18,136
Blood and immune system 764 | 17,995
Digestive Tract 764 | 18,473
Endocrine System 764 | 18,512
Female tissues 764 | 18,647
Male tissues 764 | 17,969
Nervous System 764 | 18,561
Urinary Tract 764 | 18,444
Cardiovascular System 763 | 17,958
Respiratory system 763 | 17,484
Skin and soft tissues 757 | 18,115

Target Family

Non-IDG 449 | 11,971
Enzyme 211 | 4,146
Transcription Factor 34 | 1,400
Kinase 32 | 634
Epigenetic 15 | 242
Transporter 12 | 473
GPCR 7 | 406
Ion Channel 2 | 341
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.61325 409.6 244
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
Interleukin enhancer-binding factor 2 ILF2 Tbio Non-IDG -1.51960 36.4 249
Interleukin enhancer-binding factor 3 ILF3 Tbio Non-IDG -2.09543 135.8 239