Development Level

Tbio 129 | 10,625
Tchem 109 | 1,890
Tclin 31 | 602
Tdark 12 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 1 | 145

IMPC Term

preweaning lethality, complete... 9 | 633
decreased fasted circulating g... 6 | 49
embryonic lethality prior to t... 6 | 187
decreased bone mineral content 5 | 157
decreased lean body mass 5 | 195
decreased total body fat amoun... 5 | 186
impaired glucose tolerance 5 | 52
increased circulating alkaline... 5 | 119
preweaning lethality, incomple... 5 | 260
abnormal bone structure 4 | 131
decreased body length 4 | 108
decreased circulating insulin ... 4 | 75
decreased mean corpuscular vol... 4 | 50
increased circulating HDL chol... 4 | 63
increased lean body mass 4 | 107
increased mean corpuscular vol... 4 | 91
short tibia 4 | 82
abnormal embryo size 3 | 112
abnormal retina morphology 3 | 100
abnormal retinal pigmentation 3 | 61
abnormal snout morphology 3 | 18
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating choleste... 3 | 85
decreased grip strength 3 | 123
decreased startle reflex 3 | 48
enlarged heart 3 | 111
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
increased or absent threshold ... 3 | 128
increased total body fat amoun... 3 | 57
straub tail 3 | 26
tremors 3 | 34
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
abnormal coat/ hair morphology 2 | 18
abnormal femur morphology 2 | 14
abnormal forebrain development 2 | 18
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal hindbrain development 2 | 24
abnormal lens morphology 2 | 73
abnormal locomotor activation 2 | 26
abnormal lung morphology 2 | 15
abnormal neural tube closure 2 | 37
abnormal sleep behavior 2 | 63
cataract 2 | 26
decreased CD8-positive, alpha-... 2 | 26
decreased T cell number 2 | 31
decreased body weight 2 | 174
decreased circulating alanine ... 2 | 53
decreased circulating alkaline... 2 | 41
decreased circulating glucose ... 2 | 121
decreased circulating glycerol... 2 | 19
decreased mean corpuscular hem... 2 | 34
decreased pulmonary respirator... 2 | 4
embryonic lethality prior to o... 2 | 148
enlarged stomach 2 | 2
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased body length 2 | 20
increased bone mineral density 2 | 52
increased circulating calcium ... 2 | 32
increased circulating choleste... 2 | 53
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 20
increased mean corpuscular hem... 2 | 93
increased vertical activity 2 | 18
lethargy 2 | 5
male infertility 2 | 62
persistence of hyaloid vascula... 2 | 22
prenatal lethality prior to he... 2 | 64
small thymus 2 | 11
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal heart morphology 1 | 51
abnormal startle reflex 1 | 14
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
convulsive seizures 1 | 11
decreased IgG1 level 1 | 4
decreased alpha-beta T cell nu... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating creatini... 1 | 31
decreased circulating potassiu... 1 | 17
decreased circulating triglyce... 1 | 83
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
female infertility 1 | 34
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29
increased circulating iron lev... 1 | 25
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
premature death 1 | 5
vertebral fusion 1 | 23

Disease

Vascular disease 281 | 281
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 274 | 18,473
Nervous System 274 | 18,561
Female tissues 273 | 18,647
Endocrine System 272 | 18,512
Liver and Pancreas 272 | 18,136
Male tissues 272 | 17,969
Urinary Tract 272 | 18,444
Blood and immune system 271 | 17,995
Cardiovascular System 270 | 17,958
Skin and soft tissues 270 | 18,115
Respiratory system 268 | 17,484

Target Family

Non-IDG 132 | 11,969
Enzyme 68 | 4,146
Kinase 22 | 634
Transcription Factor 21 | 1,400
GPCR 14 | 408
Ion Channel 11 | 341
Transporter 7 | 473
Epigenetic 3 | 242
Nuclear Receptor 3 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.22244 1606.1 561
Bifunctional purine biosynthesis protein PURH ATIC Tchem Non-IDG -2.90129 787.3 198
Mitogen-activated protein kinase kinase kinase 5 MAP3K5 Tchem Kinase -2.61089 467.7 1104
Aldose reductase AKR1B1 Tclin Enzyme -3.25679 1851.0 302
Metalloproteinase inhibitor 4 TIMP4 Tbio Enzyme -1.99351 100.3 348
Glyceraldehyde-3-phosphate dehydrogenase GAPDH Tchem Enzyme -3.66772 4499.1 1649
Angiopoietin-1 receptor TEK Tclin Kinase -2.97787 855.6 877
C-X-C chemokine receptor type 2 CXCR2 Tchem GPCR -2.84060 671.4 536
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.04744 808.6 1868
Caspase-8 CASP8 Tchem Enzyme -3.51864 2954.7 930