Targets

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Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Myeloid differentiation primary response protein MyD88	MYD88	Tbio	Non-IDG	-3.22244	1606.1	561
Bifunctional purine biosynthesis protein PURH	ATIC	Tchem	Non-IDG	-2.90129	787.3	198
Mitogen-activated protein kinase kinase kinase 5	MAP3K5	Tchem	Kinase	-2.61089	467.7	1104
Aldose reductase	AKR1B1	Tclin	Enzyme	-3.25679	1851.0	302
Metalloproteinase inhibitor 4	TIMP4	Tbio	Enzyme	-1.99351	100.3	348
Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	Tchem	Enzyme	-3.66772	4499.1	1649
Angiopoietin-1 receptor	TEK	Tclin	Kinase	-2.97787	855.6	877
C-X-C chemokine receptor type 2	CXCR2	Tchem	GPCR	-2.84060	671.4	536
Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	Tclin	Kinase	-3.04744	808.6	1868
Caspase-8	CASP8	Tchem	Enzyme	-3.51864	2954.7	930

	Tbio	129 \| 10,625
	Tchem	109 \| 1,890
	Tclin	31 \| 602
	Tdark	12 \| 7,003

	preweaning lethality, complete...	9 \| 633
	decreased fasted circulating g...	6 \| 49
	embryonic lethality prior to t...	6 \| 187
	decreased bone mineral content	5 \| 157
	decreased lean body mass	5 \| 195
	decreased total body fat amoun...	5 \| 186
	impaired glucose tolerance	5 \| 52
	increased circulating alkaline...	5 \| 119
	preweaning lethality, incomple...	5 \| 260
	abnormal bone structure	4 \| 131
	decreased body length	4 \| 108
	decreased circulating insulin ...	4 \| 75
	decreased mean corpuscular vol...	4 \| 50
	increased circulating HDL chol...	4 \| 63
	increased lean body mass	4 \| 107
	increased mean corpuscular vol...	4 \| 91
	short tibia	4 \| 82
	abnormal embryo size	3 \| 112
	abnormal retina morphology	3 \| 100
	abnormal retinal pigmentation	3 \| 61
	abnormal snout morphology	3 \| 18
	decreased bone mineral density	3 \| 126
	decreased circulating HDL chol...	3 \| 77
	decreased circulating choleste...	3 \| 85
	decreased grip strength	3 \| 123
	decreased startle reflex	3 \| 48
	enlarged heart	3 \| 111
	increased fasted circulating g...	3 \| 68
	increased grip strength	3 \| 83
	increased or absent threshold ...	3 \| 128
	increased total body fat amoun...	3 \| 57
	straub tail	3 \| 26
	tremors	3 \| 34
	abnormal behavior	2 \| 226
	abnormal bone mineralization	2 \| 55
	abnormal coat/ hair morphology	2 \| 18
	abnormal femur morphology	2 \| 14
	abnormal forebrain development	2 \| 18
	abnormal gait	2 \| 51
	abnormal heart left ventricle ...	2 \| 20
	abnormal hindbrain development	2 \| 24
	abnormal lens morphology	2 \| 73
	abnormal locomotor activation	2 \| 26
	abnormal lung morphology	2 \| 15
	abnormal neural tube closure	2 \| 37
	abnormal sleep behavior	2 \| 63
	cataract	2 \| 26
	decreased CD8-positive, alpha-...	2 \| 26
	decreased T cell number	2 \| 31
	decreased body weight	2 \| 174
	decreased circulating alanine ...	2 \| 53
	decreased circulating alkaline...	2 \| 41
	decreased circulating glucose ...	2 \| 121
	decreased circulating glycerol...	2 \| 19
	decreased mean corpuscular hem...	2 \| 34
	decreased pulmonary respirator...	2 \| 4
	embryonic lethality prior to o...	2 \| 148
	enlarged stomach	2 \| 2
	hypoactivity	2 \| 89
	improved glucose tolerance	2 \| 56
	increased body length	2 \| 20
	increased bone mineral density	2 \| 52
	increased circulating calcium ...	2 \| 32
	increased circulating choleste...	2 \| 53
	increased circulating sodium l...	2 \| 71
	increased circulating total pr...	2 \| 20
	increased mean corpuscular hem...	2 \| 93
	increased vertical activity	2 \| 18
	lethargy	2 \| 5
	male infertility	2 \| 62
	persistence of hyaloid vascula...	2 \| 22
	prenatal lethality prior to he...	2 \| 64
	small thymus	2 \| 11
	thrombocytopenia	2 \| 46
	abnormal behavioral response t...	1 \| 52
	abnormal coping response	1 \| 12
	abnormal cranium morphology	1 \| 32
	abnormal heart morphology	1 \| 51
	abnormal startle reflex	1 \| 14
	abnormal testis morphology	1 \| 30
	abnormal tooth morphology	1 \| 24
	convulsive seizures	1 \| 11
	decreased IgG1 level	1 \| 4
	decreased alpha-beta T cell nu...	1 \| 12
	decreased blood urea nitrogen ...	1 \| 31
	decreased caudal vertebrae num...	1 \| 49
	decreased cervical vertebrae n...	1 \| 12
	decreased circulating creatini...	1 \| 31
	decreased circulating potassiu...	1 \| 17
	decreased circulating triglyce...	1 \| 83
	decreased hematocrit	1 \| 25
	decreased hemoglobin content	1 \| 53
	female infertility	1 \| 34
	increased blood urea nitrogen ...	1 \| 44
	increased circulating creatini...	1 \| 29
	increased circulating iron lev...	1 \| 25
	increased sacral vertebrae num...	1 \| 62
	limb grasping	1 \| 35
	premature death	1 \| 5
	vertebral fusion	1 \| 23

	Vascular disease	281 \| 281
	ovarian cancer	8,492 \| 8,492
	osteosarcoma	7,933 \| 7,933
	psoriasis	6,685 \| 6,685
	medulloblastoma, large-cell	6,234 \| 6,234
	glioblastoma	5,572 \| 5,572
	lung cancer	4,473 \| 4,473
	atypical teratoid / rhabdoid tumor	4,369 \| 4,369
	intraductal papillary-mucinous neoplasm (IPMN)	3,289 \| 3,289
	malignant mesothelioma	3,163 \| 3,163
	Breast cancer	3,099 \| 3,099
	pilocytic astrocytoma	3,086 \| 3,086
	primitive neuroectodermal tumor	3,031 \| 3,031
	intraductal papillary-mucinous carcinoma (IPMC)	2,988 \| 2,988
	intraductal papillary-mucinous adenoma (IPMA)	2,956 \| 2,956
	invasive ductal carcinoma	2,950 \| 2,950
	oligodendroglioma	2,849 \| 2,849
	lung carcinoma	2,844 \| 2,844
	non-small cell lung cancer	2,798 \| 2,798
	lung adenocarcinoma	2,714 \| 2,714
	pediatric high grade glioma	2,712 \| 2,712
	ependymoma	2,514 \| 2,514
	Cancer	2,346 \| 2,346
	pancreatic cancer	2,300 \| 2,300
	interstitial cystitis	2,299 \| 2,299
	subependymal giant cell astrocytoma	2,287 \| 2,287
	group 3 medulloblastoma	2,254 \| 2,254
	astrocytic glioma	2,241 \| 2,241
	adult high grade glioma	2,148 \| 2,148
	Carcinoma	2,147 \| 2,147
	ulcerative colitis	2,087 \| 2,087
	pituitary cancer	1,972 \| 1,972
	Pick disease	1,893 \| 1,893
	group 4 medulloblastoma	1,875 \| 1,875
	pancreatic ductal adenocarcinoma liver metastasis	1,795 \| 1,795
	ductal carcinoma in situ	1,745 \| 1,745
	cystic fibrosis	1,670 \| 1,670
	diabetes mellitus	1,663 \| 1,663
	breast carcinoma	1,614 \| 1,614
	tuberculosis	1,563 \| 1,563
	posterior fossa group B ependymoma	1,530 \| 1,530
	medulloblastoma	1,524 \| 1,524
	posterior fossa group A ependymoma	1,511 \| 1,511
	astrocytoma	1,493 \| 1,493
	sonic hedgehog group medulloblastoma	1,482 \| 1,482
	colon cancer	1,475 \| 1,475
	adrenocortical carcinoma	1,427 \| 1,427
	Multiple myeloma	1,328 \| 1,328
	primary pancreatic ductal adenocarcinoma	1,271 \| 1,271
	juvenile dermatomyositis	1,189 \| 1,189
	Rheumatoid Arthritis	1,171 \| 1,171
	acute quadriplegic myopathy	1,157 \| 1,157
	atypical teratoid/rhabdoid tumor	1,095 \| 1,095
	spina bifida	1,064 \| 1,064
	cutaneous lupus erythematosus	1,056 \| 1,056
	nasopharyngeal carcinoma	1,056 \| 1,056
	dermatomyositis	967 \| 967
	Atopic dermatitis	944 \| 944
	active Crohn's disease	918 \| 918
	non primary Sjogren syndrome sicca	840 \| 840
	gastric carcinoma	832 \| 832
	primary Sjogren syndrome	789 \| 789
	acute myeloid leukemia	785 \| 785
	Waldenstrons macroglobulinemia	765 \| 765
	esophageal adenocarcinoma	737 \| 737
	tuberculosis and treatment for 6 months	686 \| 686
	progressive supranuclear palsy	674 \| 674
	aldosterone-producing adenoma	664 \| 664
	Alzheimer's disease	644 \| 644
	Obesity	616 \| 616
	Duchenne muscular dystrophy	602 \| 602
	Intellectual disability	573 \| 573
	pancreatic carcinoma	567 \| 567
	fibroadenoma	557 \| 557
	hepatocellular carcinoma	550 \| 550
	Down syndrome	548 \| 548
	Endometriosis	535 \| 535
	chronic rhinosinusitis	512 \| 512
	Schizophrenia	503 \| 503
	autosomal dominant Emery-Dreifuss muscular dystrophy	499 \| 499
	Multiple Sclerosis	498 \| 498
	mucosa-associated lymphoid tissue lymphoma	480 \| 480
	active ulcerative colitis	477 \| 477
	Prostatic Neoplasms	471 \| 471
	IGA Glomerulonephritis	454 \| 454
	gastric cancer	436 \| 436
	Amyotrophic Lateral Sclerosis	432 \| 432
	non-small cell lung carcinoma	413 \| 413
	Mammary Neoplasms	410 \| 410
	inflammatory breast cancer	404 \| 404
	Kidney disease	397 \| 397
	Neurodegenerative disease	383 \| 383
	sarcoidosis	368 \| 368
	Parkinson's disease	364 \| 364
	Asthma	349 \| 349
	glioblastoma multiforme	347 \| 347
	Epilepsy	346 \| 346
	Polycystic Ovary Syndrome	335 \| 335
	nephrosclerosis	329 \| 329
	tuberculosis and treatment for 3 months	327 \| 327
	Autistic Disorder	320 \| 320

	Digestive Tract	274 \| 18,473
	Nervous System	274 \| 18,561
	Female tissues	273 \| 18,647
	Endocrine System	272 \| 18,512
	Liver and Pancreas	272 \| 18,136
	Male tissues	272 \| 17,969
	Urinary Tract	272 \| 18,444
	Blood and immune system	271 \| 17,995
	Cardiovascular System	270 \| 17,958
	Skin and soft tissues	270 \| 18,115
	Respiratory system	268 \| 17,484

	Non-IDG	132 \| 11,969
	Enzyme	68 \| 4,146
	Kinase	22 \| 634
	Transcription Factor	21 \| 1,400
	GPCR	14 \| 408
	Ion Channel	11 \| 341
	Transporter	7 \| 473
	Epigenetic	3 \| 242
	Nuclear Receptor	3 \| 48

Development Level

Collection

IMPC Term

Disease

Tissue

Target Family

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Grant Funding IC

Grant Activity

Data Source