Targets

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Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Dual specificity protein phosphatase 1	DUSP1	Tchem	Enzyme	-2.88260	810.9	388
ATP-binding cassette sub-family A member 1	ABCA1	Tclin	Transporter	-3.15111	1451.8	388
Integrin alpha-2	ITGA2	Tbio	Non-IDG	-2.58423	335.9	895
Thrombospondin-1	THBS1	Tbio	Non-IDG	-3.06622	1281.6	504
Inactive caspase-12	CASP12	Tbio	Enzyme	-2.64252	415.1	429
TSC22 domain family protein 1	TSC22D1	Tbio	Transcription Factor	-1.54599	46.0	300
Estrogen receptor	ESR1	Tclin	Nuclear Receptor	-4.00480	8421.6	2610

	Tbio	185 \| 11,651
	Tchem	92 \| 1,388
	Tclin	33 \| 612
	Tdark	9 \| 6,593

	preweaning lethality, complete...	21 \| 979
	preweaning lethality, incomple...	11 \| 499
	decreased total body fat amoun...	8 \| 207
	embryonic lethality prior to t...	8 \| 278
	increased circulating HDL chol...	7 \| 80
	increased circulating alkaline...	7 \| 122
	increased total body fat amoun...	7 \| 134
	decreased fasted circulating g...	5 \| 65
	decreased lean body mass	5 \| 135
	enlarged heart	5 \| 210
	increased circulating choleste...	5 \| 66
	abnormal behavior	4 \| 298
	abnormal bone structure	4 \| 187
	abnormal embryo size	4 \| 220
	decreased mean corpuscular vol...	4 \| 79
	embryonic lethality prior to o...	4 \| 239
	impaired glucose tolerance	4 \| 75
	increased lean body mass	4 \| 172
	increased mean corpuscular vol...	4 \| 92
	tremors	4 \| 39
	abnormal coat- hair morphology	3 \| 19
	abnormal gait	3 \| 69
	abnormal heart morphology	3 \| 162
	abnormal retina morphology	3 \| 71
	cataract	3 \| 92
	decreased body length	3 \| 101
	decreased circulating HDL chol...	3 \| 68
	decreased circulating choleste...	3 \| 93
	decreased circulating insulin ...	3 \| 76
	decreased grip strength	3 \| 116
	decreased startle reflex	3 \| 75
	decreased vertical activity	3 \| 208
	hypoactivity	3 \| 132
	increased circulating chloride...	3 \| 41
	increased circulating total pr...	3 \| 28
	increased fasted circulating g...	3 \| 76
	increased red blood cell distr...	3 \| 34
	increased startle reflex	3 \| 112
	short tibia	3 \| 97
	abnormal bone mineralization	2 \| 38
	abnormal femur morphology	2 \| 14
	abnormal forebrain development	2 \| 20
	abnormal hindbrain development	2 \| 16
	abnormal lens morphology	2 \| 81
	abnormal locomotor behavior	2 \| 24
	abnormal neural tube closure	2 \| 46
	abnormal retinal blood vessel ...	2 \| 26
	abnormal sleep behavior	2 \| 70
	abnormal snout morphology	2 \| 23
	decreased body weight	2 \| 161
	decreased bone mineral content	2 \| 151
	decreased circulating alanine ...	2 \| 47
	decreased circulating alkaline...	2 \| 46
	decreased circulating free fat...	2 \| 31
	decreased circulating triglyce...	2 \| 79
	decreased erythrocyte cell num...	2 \| 62
	decreased heart left ventricle...	2 \| 28
	decreased lymphocyte cell numb...	2 \| 83
	decreased mean corpuscular hem...	2 \| 31
	decreased neutrophil cell numb...	2 \| 42
	decreased pulmonary respirator...	2 \| 5
	decreased red blood cell distr...	2 \| 41
	enlarged stomach	2 \| 2
	improved glucose tolerance	2 \| 79
	increased body length	2 \| 32
	increased circulating amylase ...	2 \| 25
	increased circulating calcium ...	2 \| 34
	increased circulating iron lev...	2 \| 30
	increased circulating phosphat...	2 \| 26
	increased circulating triglyce...	2 \| 42
	increased grip strength	2 \| 41
	increased lymphocyte cell numb...	2 \| 32
	increased mean corpuscular hem...	2 \| 96
	increased monocyte cell number	2 \| 63
	male infertility	2 \| 123
	prenatal lethality prior to he...	2 \| 87
	small thymus	2 \| 16
	thin ventricular wall	2 \| 24
	thrombocytopenia	2 \| 56
	abnormal epididymis morphology	1 \| 42
	abnormal head morphology	1 \| 10
	abnormal heart left ventricle ...	1 \| 16
	abnormal liver morphology	1 \| 17
	abnormal lung morphology	1 \| 26
	abnormal retinal vasculature m...	1 \| 27
	convulsive seizures	1 \| 13
	decreased IgG1 level	1 \| 8
	decreased T cell number	1 \| 15
	decreased circulating amylase ...	1 \| 28
	decreased circulating calcium ...	1 \| 36
	decreased circulating iron lev...	1 \| 32
	decreased hematocrit	1 \| 46
	increased bone mineral density	1 \| 72
	increased circulating bilirubi...	1 \| 16
	increased circulating serum al...	1 \| 22
	increased eosinophil cell numb...	1 \| 11
	increased heart weight	1 \| 62
	increased hemoglobin content	1 \| 45
	persistence of hyaloid vascula...	1 \| 33
	vertebral fusion	1 \| 23

	Vascular disease	319 \| 319
	Carcinoma	11,493 \| 11,493
	ovarian cancer	8,520 \| 8,520
	osteosarcoma	7,950 \| 7,950
	psoriasis	6,694 \| 6,694
	medulloblastoma, large-cell	6,241 \| 6,241
	glioblastoma	5,792 \| 5,792
	atypical teratoid / rhabdoid tumor	5,112 \| 5,112
	lung cancer	4,740 \| 4,740
	ependymoma	4,679 \| 4,679
	group 3 medulloblastoma	4,104 \| 4,104
	adult high grade glioma	3,801 \| 3,801
	Breast cancer	3,578 \| 3,578
	intraductal papillary-mucinous neoplasm (IPMN)	3,291 \| 3,291
	malignant mesothelioma	3,232 \| 3,232
	Astrocytoma, Pilocytic	3,081 \| 3,081
	primitive neuroectodermal tumor	3,035 \| 3,035
	intraductal papillary-mucinous carcinoma (IPMC)	2,989 \| 2,989
	intraductal papillary-mucinous adenoma (IPMA)	2,955 \| 2,955
	invasive ductal carcinoma	2,951 \| 2,951
	non-small cell lung cancer	2,890 \| 2,890
	oligodendroglioma	2,850 \| 2,850
	lung carcinoma	2,843 \| 2,843
	lung adenocarcinoma	2,716 \| 2,716
	Kidney cancer	2,613 \| 2,613
	astrocytic glioma	2,597 \| 2,597
	Cancer	2,499 \| 2,499
	pancreatic cancer	2,398 \| 2,398
	interstitial cystitis	2,312 \| 2,312
	subependymal giant cell astrocytoma	2,287 \| 2,287
	tuberculosis	2,010 \| 2,010
	pituitary cancer	1,972 \| 1,972
	pancreatic ductal adenocarcinoma liver metastasis	1,962 \| 1,962
	Pick disease	1,894 \| 1,894
	group 4 medulloblastoma	1,855 \| 1,855
	ulcerative colitis	1,819 \| 1,819
	ductal carcinoma in situ	1,745 \| 1,745
	diabetes mellitus	1,728 \| 1,728
	cystic fibrosis	1,696 \| 1,696
	breast carcinoma	1,638 \| 1,638
	colon cancer	1,478 \| 1,478
	Autosomal recessive predisposition	1,442 \| 1,442
	adrenocortical carcinoma	1,428 \| 1,428
	Multiple myeloma	1,332 \| 1,332
	Rheumatoid arthritis	1,191 \| 1,191
	juvenile dermatomyositis	1,187 \| 1,187
	Schizophrenia	1,160 \| 1,160
	acute quadriplegic myopathy	1,158 \| 1,158
	astrocytoma	1,146 \| 1,146
	primary pancreatic ductal adenocarcinoma	1,109 \| 1,109
	spina bifida	1,074 \| 1,074
	pediatric high grade glioma	1,064 \| 1,064
	nasopharyngeal carcinoma	1,058 \| 1,058
	cutaneous lupus erythematosus	1,057 \| 1,057
	Intellectual disability	1,016 \| 1,016
	dermatomyositis	966 \| 966
	Atopic dermatitis	952 \| 952
	active Crohn's disease	922 \| 922
	non primary Sjogren syndrome sicca	891 \| 891
	gastric carcinoma	807 \| 807
	Epilepsy	792 \| 792
	acute myeloid leukemia	783 \| 783
	Liver Cirrhosis, Experimental	769 \| 769
	Waldenstrons macroglobulinemia	765 \| 765
	active ulcerative colitis	764 \| 764
	esophageal adenocarcinoma	737 \| 737
	primary Sjogren syndrome	735 \| 735
	medulloblastoma	720 \| 720
	Melanoma	711 \| 711
	Obesity	678 \| 678
	progressive supranuclear palsy	676 \| 676
	Bipolar Disorder	666 \| 666
	aldosterone-producing adenoma	665 \| 665
	Alzheimer's disease	658 \| 658
	Dull intelligence	645 \| 645
	Low intelligence	645 \| 645
	Mental Retardation	645 \| 645
	Mental deficiency	645 \| 645
	Poor school performance	645 \| 645
	Cognitive delay	608 \| 608
	Global developmental delay	608 \| 608
	Mental and motor retardation	608 \| 608
	Liver cancer	604 \| 604
	Duchenne muscular dystrophy	601 \| 601
	Seizures	596 \| 596
	Muscle hypotonia	571 \| 571
	pancreatic carcinoma	562 \| 562
	fibroadenoma	559 \| 559
	hepatocellular carcinoma	547 \| 547
	Endometriosis	540 \| 540
	Multiple Sclerosis	540 \| 540
	Short stature	531 \| 531
	chronic rhinosinusitis	512 \| 512
	autosomal dominant Emery-Dreifuss muscular dystrophy	510 \| 510
	Down syndrome	499 \| 499
	Prostatic Neoplasms	495 \| 495
	mucosa-associated lymphoid tissue lymphoma	484 \| 484
	Skin cancer	469 \| 469
	posterior fossa group A ependymoma	468 \| 468
	sonic hedgehog group medulloblastoma	467 \| 467
	gastric cancer	459 \| 459

	Digestive Tract	309 \| 17,369
	Endocrine System	307 \| 18,159
	Female tissues	307 \| 17,400
	Skin and soft tissues	306 \| 17,230
	Liver and Pancreas	303 \| 16,750
	Urinary Tract	302 \| 16,678
	Male tissues	300 \| 17,142
	Blood and immune system	299 \| 16,909
	Respiratory system	296 \| 16,393
	Nervous System	293 \| 16,725
	Cardiovascular System	279 \| 15,192

	Non-IDG	155 \| 12,091
	Enzyme	77 \| 4,145
	Transcription Factor	25 \| 1,400
	Kinase	23 \| 634
	GPCR	14 \| 408
	Ion Channel	12 \| 344
	Transporter	7 \| 473
	Epigenetic	3 \| 242
	Nuclear Receptor	3 \| 48

Development Level

IMPC Phenotype

Disease

Tissue

Target Family

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Data Source