Development Level

Tbio 106 | 10,625
Tdark 41 | 7,003
Tchem 28 | 1,890
Tclin 17 | 602

Collection

Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 11 | 633
preweaning lethality, incomple... 7 | 260
abnormal retina morphology 4 | 100
decreased circulating fructosa... 4 | 31
decreased total body fat amoun... 4 | 186
abnormal retinal pigmentation 3 | 61
decreased body weight 3 | 174
decreased fasted circulating g... 3 | 49
decreased lean body mass 3 | 195
increased bone mineral content 3 | 92
increased circulating aspartat... 3 | 17
increased lean body mass 3 | 107
abnormal behavior 2 | 226
abnormal lens morphology 2 | 73
abnormal seminal vesicle morph... 2 | 47
abnormal testis morphology 2 | 30
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating aspartat... 2 | 27
decreased circulating glucose ... 2 | 121
decreased grip strength 2 | 123
decreased startle reflex 2 | 48
hyperactivity 2 | 108
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased circulating alkaline... 2 | 119
increased leukocyte cell numbe... 2 | 37
increased red blood cell distr... 2 | 21
increased startle reflex 2 | 38
prenatal lethality prior to he... 2 | 64
small testis 2 | 37
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal heart left ventricle ... 1 | 20
abnormal heart morphology 1 | 51
abnormal lung morphology 1 | 15
abnormal lymph node morphology 1 | 3
abnormal retinal vasculature m... 1 | 15
abnormal startle reflex 1 | 14
abnormal vertebrae morphology 1 | 14
cardiovascular system phenotyp... 1 | 35
convulsive seizures 1 | 11
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating iron lev... 1 | 25
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased eosinophil cell numb... 1 | 41
decreased gamma-delta T cell n... 1 | 18
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
hypoactivity 1 | 89
increased B cell number 1 | 23
increased CD4-positive NK T ce... 1 | 3
increased CD4-positive, CD25-p... 1 | 18
increased Ly6C high monocyte n... 1 | 12
increased NK T cell number 1 | 11
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased caudal vertebrae num... 1 | 8
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20
increased erythrocyte cell num... 1 | 26
increased gamma-delta T cell n... 1 | 16
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased memory-marker CD4-po... 1 | 3
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
straub tail 1 | 26
thrombocytosis 1 | 23

Disease

Type 2 diabetes mellitus 192 | 192
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Cardiovascular System 189 | 17,958
Liver and Pancreas 189 | 18,136
Digestive Tract 188 | 18,473
Female tissues 188 | 18,647
Male tissues 188 | 17,969
Nervous System 188 | 18,561
Endocrine System 187 | 18,512
Urinary Tract 187 | 18,444
Skin and soft tissues 186 | 18,115
Blood and immune system 184 | 17,995
Respiratory system 180 | 17,484

Target Family

Non-IDG 96 | 11,969
Enzyme 43 | 4,146
Transcription Factor 18 | 1,400
Ion Channel 9 | 341
Transporter 8 | 473
GPCR 7 | 408
Kinase 6 | 634
Nuclear Receptor 3 | 48
Epigenetic 2 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Solute carrier organic anion transporter family member 3A1 SLCO3A1 Tbio Transporter -1.38328 23.0 28
La-related protein 6 LARP6 Tbio Non-IDG -1.40785 25.6 72
Zinc finger protein ZFPM2 ZFPM2 Tbio Transcription Factor -1.75745 57.5 78
Tomoregulin-2 TMEFF2 Tbio Non-IDG -1.85867 81.2 150
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 ARAP1 Tbio Non-IDG -0.97819 13.6 86
Calpain-10 CAPN10 Tbio Non-IDG -2.26869 193.5 79
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform PPP2R2C Tbio Enzyme -1.11980 11.3 62
AMP deaminase 3 AMPD3 Tchem Enzyme -1.84398 66.0 113
Zinc finger and BTB domain-containing protein 20 ZBTB20 Tbio Transcription Factor -2.09716 123.5 71
Potassium channel subfamily U member 1 KCNU1 Tbio Ion Channel -1.59652 36.7 57