Development Level

Tbio 72 | 11,651
Tclin 28 | 612
Tchem 13 | 1,388

IMPC Phenotype

preweaning lethality, complete... 14 | 979
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
increased mean corpuscular hem... 4 | 96
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
decreased bone mineral content 3 | 151
abnormal eye morphology 2 | 68
abnormal iris morphology 2 | 13
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
decreased body weight 2 | 161
decreased circulating calcium ... 2 | 36
decreased circulating glucose ... 2 | 126
decreased circulating iron lev... 2 | 32
decreased fasted circulating g... 2 | 65
decreased hematocrit 2 | 46
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
hyperactivity 2 | 148
hypoactivity 2 | 132
increased bone mineral density 2 | 72
increased lymphocyte cell numb... 2 | 32
male infertility 2 | 123
pallor 2 | 34
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal placenta size 1 | 20
abnormal placenta vasculature 1 | 2
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal spine curvature 1 | 9
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
anophthalmia 1 | 33
cataract 1 | 92
cyanosis 1 | 7
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
pale yolk sac 1 | 25
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged RR interval 1 | 8
respiratory system phenotype 1 | 2
small kidney 1 | 16
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Tremor 113 | 113
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 111 | 18,159
Female tissues 108 | 17,400
Digestive Tract 107 | 17,369
Nervous System 107 | 16,725
Male tissues 105 | 17,142
Skin and soft tissues 105 | 17,230
Liver and Pancreas 103 | 16,750
Urinary Tract 102 | 16,678
Blood and immune system 101 | 16,909
Respiratory system 99 | 16,393
Cardiovascular System 89 | 15,192

Target Family

Non-IDG 46 | 12,091
Enzyme 30 | 4,145
Ion Channel 13 | 344
GPCR 7 | 408
Transcription Factor 5 | 1,400
Transporter 5 | 473
Kinase 4 | 634
Nuclear Receptor 2 | 48
Epigenetic 1 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Transmembrane protein 70, mitochondrial TMEM70 Tbio Non-IDG -1.36229 24.6 93
Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S Tclin Ion Channel -2.21321 163.9 114
Acid ceramidase ASAH1 Tchem Enzyme -2.94716 848.0 203
D(2) dopamine receptor DRD2 Tclin GPCR -3.28700 1882.2 264
Transthyretin TTR Tclin Non-IDG -3.79596 6198.3 750
H(+)/Cl(-) exchange transporter 7 CLCN7 Tbio Ion Channel -1.96458 100.7 151
Platelet-derived growth factor subunit B PDGFB Tchem Non-IDG -3.27151 1795.5 434
Zinc transporter ZIP4 SLC39A4 Tbio Transporter -2.05142 112.2 124
Cullin-4B CUL4B Tbio Non-IDG -1.68710 54.9 251