Development Level

Tbio 189 | 11,651
Tchem 65 | 1,388
Tclin 36 | 612
Tdark 10 | 6,593

Collection

Ion Channel: IDG Consortium (T... 1 | 99
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 28 | 979
abnormal behavior 8 | 298
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 6 | 278
enlarged heart 6 | 210
abnormal seminal vesicle morph... 5 | 114
increased circulating alkaline... 5 | 122
abnormal heart morphology 4 | 162
abnormal lens morphology 4 | 81
abnormal spleen morphology 4 | 55
embryonic lethality prior to o... 4 | 239
abnormal embryo size 3 | 220
abnormal epididymis morphology 3 | 42
abnormal kidney morphology 3 | 65
abnormal testis morphology 3 | 43
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased vertical activity 3 | 208
enlarged spleen 3 | 41
hypoactivity 3 | 132
increased bone mineral content 3 | 108
increased bone mineral density 3 | 72
increased circulating sodium l... 3 | 71
increased mean corpuscular vol... 3 | 92
increased or absent threshold ... 3 | 101
male infertility 3 | 123
prolonged QT interval 3 | 38
small superior vagus ganglion 3 | 74
small testis 3 | 58
abnormal QT variability 2 | 10
abnormal behavioral response t... 2 | 66
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal facial morphology 2 | 17
abnormal gait 2 | 69
abnormal lung morphology 2 | 26
abnormal retinal blood vessel ... 2 | 26
abnormal thymus morphology 2 | 7
abnormal urinary bladder morph... 2 | 11
anophthalmia 2 | 33
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased circulating alanine ... 2 | 47
decreased circulating bilirubi... 2 | 19
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased prepulse inhibition 2 | 82
female infertility 2 | 60
hydrometra 2 | 53
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased circulating glucose ... 2 | 24
increased circulating triglyce... 2 | 42
increased heart rate 2 | 23
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
microphthalmia 2 | 26
prolonged ST segment 2 | 36
short tibia 2 | 97
small seminal vesicle 2 | 10
abnormal body wall morphology 1 | 9
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased hematocrit 1 | 46
decreased mean corpuscular hem... 1 | 31
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 38
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
long tibia 1 | 25
prenatal lethality 1 | 28
small kidney 1 | 16
small thymus 1 | 16
trunk curl 1 | 16

Disease

Stomach Neoplasms 300 | 300
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 295 | 18,159
Female tissues 294 | 17,400
Blood and immune system 291 | 16,909
Digestive Tract 291 | 17,369
Male tissues 291 | 17,142
Skin and soft tissues 290 | 17,230
Urinary Tract 290 | 16,678
Liver and Pancreas 289 | 16,750
Nervous System 289 | 16,725
Respiratory system 289 | 16,393
Cardiovascular System 272 | 15,192

Target Family

Non-IDG 147 | 12,091
Enzyme 83 | 4,145
Transcription Factor 26 | 1,400
Kinase 24 | 634
GPCR 7 | 408
Epigenetic 6 | 242
Nuclear Receptor 4 | 48
Ion Channel 2 | 344
Transporter 1 | 473

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275