Development Level

Tbio 76 | 11,651
Tchem 34 | 1,388
Tclin 18 | 612
Tdark 1 | 6,593

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal lens morphology 3 | 81
embryonic lethality prior to o... 3 | 239
prenatal lethality prior to he... 3 | 87
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased circulating insulin ... 2 | 76
decreased vertical activity 2 | 208
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased circulating HDL chol... 2 | 80
increased mean corpuscular vol... 2 | 92
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
cardiovascular system phenotyp... 1 | 36
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating fructosa... 1 | 30
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased aggression 1 | 4
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased body weight 1 | 25
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased grip strength 1 | 41
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
male infertility 1 | 123
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
shortened RR interval 1 | 17
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Squamous cell carcinoma 129 | 129
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 125 | 17,369
Skin and soft tissues 125 | 17,230
Urinary Tract 125 | 16,678
Endocrine System 124 | 18,159
Female tissues 124 | 17,400
Blood and immune system 121 | 16,909
Male tissues 121 | 17,142
Respiratory system 118 | 16,393
Nervous System 117 | 16,725
Liver and Pancreas 116 | 16,750
Cardiovascular System 110 | 15,192

Target Family

Non-IDG 61 | 12,091
Enzyme 28 | 4,145
Kinase 16 | 634
Transcription Factor 9 | 1,400
Epigenetic 7 | 242
GPCR 5 | 408
Transporter 2 | 473
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
Nuclear receptor coactivator 3 NCOA3 Tbio Epigenetic -2.64583 480.2 417
Telomerase Cajal body protein 1 WRAP53 Tbio Enzyme -1.50893 31.5 58
14-3-3 protein sigma SFN Tbio Non-IDG -2.56638 391.2 550
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Apoptosis-associated speck-like protein containing a CARD PYCARD Tbio Non-IDG -1.86744 55.9 477
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
WW domain-containing oxidoreductase WWOX Tbio Enzyme -3.61683 3311.4 251