Development Level

Tbio 114 | 11,445
Tchem 49 | 1,598
Tclin 27 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 8 | 499
abnormal behavior 7 | 298
abnormal embryo size 6 | 220
embryonic lethality prior to o... 5 | 239
increased leukocyte cell numbe... 5 | 47
embryonic lethality prior to t... 4 | 278
hypoactivity 4 | 132
decreased body weight 3 | 161
decreased circulating serum al... 3 | 82
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
enlarged lymph nodes 3 | 37
hydrometra 3 | 53
increased blood urea nitrogen ... 3 | 48
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased lean body mass 3 | 172
increased startle reflex 3 | 112
short tibia 3 | 97
abnormal forebrain development 2 | 20
abnormal hindbrain development 2 | 16
abnormal midbrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal vertebrae morphology 2 | 18
decreased T cell number 2 | 15
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 28
decreased circulating sodium l... 2 | 22
decreased erythrocyte cell num... 2 | 62
decreased grip strength 2 | 116
decreased heart weight 2 | 27
hyperactivity 2 | 148
increased circulating free fat... 2 | 20
increased circulating potassiu... 2 | 29
increased lymphocyte cell numb... 2 | 32
increased mean platelet volume 2 | 45
increased total body fat amoun... 2 | 134
persistence of hyaloid vascula... 2 | 33
small superior vagus ganglion 2 | 74
thrombocytosis 2 | 27
abnormal colon morphology 1 | 3
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
cataract 1 | 92
cyanosis 1 | 7
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
edema 1 | 59
enlarged uterus 1 | 11
hemorrhage 1 | 23
impaired righting response 1 | 26
increased anti-nuclear antigen... 1 | 19
increased body temperature 1 | 9
increased body weight 1 | 25
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
limb grasping 1 | 41
microphthalmia 1 | 26
polycystic kidney 1 | 15
premature death 1 | 5
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
stereotypic behavior 1 | 3
thin ventricular wall 1 | 24
trunk curl 1 | 16

Disease

Splenomegaly 190 | 190
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Blood and immune system 188 | 16,909
Endocrine System 188 | 18,159
Liver and Pancreas 188 | 16,750
Digestive Tract 187 | 17,369
Male tissues 187 | 17,142
Skin and soft tissues 187 | 17,230
Female tissues 186 | 17,400
Urinary Tract 186 | 16,678
Respiratory system 182 | 16,393
Nervous System 176 | 16,725
Cardiovascular System 175 | 15,192

Target Family

Non-IDG 82 | 12,091
Enzyme 61 | 4,145
Kinase 18 | 634
Transporter 11 | 473
Transcription Factor 8 | 1,400
Ion Channel 4 | 344
Epigenetic 3 | 242
GPCR 2 | 408
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
Sorting nexin-10 SNX10 Tbio Non-IDG -1.13183 16.8 72
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
ATP-binding cassette sub-family D member 3 ABCD3 Tbio Transporter -1.82051 64.2 166
Claudin-1 CLDN1 Tbio Non-IDG -2.07626 126.7 593
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Doublecortin domain-containing protein 2 DCDC2 Tbio Non-IDG -1.71331 52.4 209
Erythrocyte band 7 integral membrane protein STOM Tbio Non-IDG -2.27504 176.9 163
Lysosomal-trafficking regulator LYST Tbio Non-IDG -1.96473 92.5 15
Coagulation factor V F5 Tbio Non-IDG -2.73955 525.3 198