Development Level

Tbio 748 | 10,625
Tchem 204 | 1,890
Tdark 147 | 7,003
Tclin 61 | 602

Collection

Eligible Kinase Proteins 7 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 42 | 633
preweaning lethality, incomple... 27 | 260
decreased total body fat amoun... 18 | 186
decreased bone mineral content 17 | 157
decreased body weight 16 | 174
decreased lean body mass 16 | 195
abnormal behavior 14 | 226
decreased body length 12 | 108
decreased circulating glucose ... 12 | 121
enlarged heart 11 | 111
short tibia 11 | 82
abnormal bone structure 10 | 131
decreased bone mineral density 10 | 126
decreased circulating triglyce... 10 | 83
decreased grip strength 10 | 123
embryonic lethality prior to o... 10 | 148
embryonic lethality prior to t... 10 | 187
increased lean body mass 10 | 107
abnormal embryo size 9 | 112
abnormal retina morphology 9 | 100
abnormal seminal vesicle morph... 8 | 47
decreased fasted circulating g... 8 | 49
hypoactivity 8 | 89
increased or absent threshold ... 8 | 128
decreased circulating HDL chol... 7 | 77
decreased circulating serum al... 7 | 79
decreased lumbar vertebrae num... 7 | 62
increased bone mineral content 7 | 92
increased bone mineral density 7 | 52
increased circulating alkaline... 7 | 119
increased grip strength 7 | 83
increased sacral vertebrae num... 7 | 62
abnormal heart morphology 6 | 51
abnormal lens morphology 6 | 73
decreased caudal vertebrae num... 6 | 49
decreased circulating choleste... 6 | 85
decreased circulating insulin ... 6 | 75
hyperactivity 6 | 108
increased blood urea nitrogen ... 6 | 44
increased circulating HDL chol... 6 | 63
increased leukocyte cell numbe... 6 | 37
increased mean corpuscular hem... 6 | 93
increased mean corpuscular vol... 6 | 91
thrombocytopenia 6 | 46
abnormal retinal pigmentation 5 | 61
decreased leukocyte cell numbe... 5 | 54
increased circulating choleste... 5 | 53
male infertility 5 | 62
prenatal lethality prior to he... 5 | 64
tremors 5 | 34
abnormal bone mineralization 4 | 55
abnormal testis morphology 4 | 30
decreased T cell number 4 | 31
decreased circulating alanine ... 4 | 53
decreased circulating alkaline... 4 | 41
decreased circulating fructosa... 4 | 31
decreased circulating iron lev... 4 | 25
decreased erythrocyte cell num... 4 | 43
decreased mature B cell number 4 | 25
decreased mean corpuscular hem... 4 | 34
decreased monocyte cell number 4 | 28
decreased rib number 4 | 59
decreased startle reflex 4 | 48
enlarged epididymis 4 | 27
enlarged spleen 4 | 26
female infertility 4 | 34
increased circulating triglyce... 4 | 24
increased hemoglobin content 4 | 45
increased neutrophil cell numb... 4 | 15
increased total body fat amoun... 4 | 57
small testis 4 | 37
vertebral transformation 4 | 12
abnormal coat/hair pigmentatio... 3 | 54
abnormal coping response 3 | 12
abnormal epididymis morphology 3 | 31
abnormal eye morphology 3 | 38
abnormal locomotor activation 3 | 26
abnormal lung morphology 3 | 15
abnormal neural tube closure 3 | 37
abnormal sleep behavior 3 | 63
abnormal spleen morphology 3 | 36
decreased CD4-positive, CD25-p... 3 | 24
decreased NK T cell number 3 | 28
decreased blood urea nitrogen ... 3 | 31
decreased circulating calcium ... 3 | 33
decreased circulating total pr... 3 | 41
decreased hematocrit 3 | 25
decreased hemoglobin content 3 | 53
decreased mean corpuscular vol... 3 | 50
decreased neutrophil cell numb... 3 | 37
decreased threshold for audito... 3 | 32
impaired righting response 3 | 19
improved glucose tolerance 3 | 56
increased body length 3 | 20
increased body weight 3 | 42
increased circulating sodium l... 3 | 71
increased rib number 3 | 41
limb grasping 3 | 35
small superior vagus ganglion 3 | 20
vertebral fusion 3 | 23

Disease

Rheumatoid Arthritis 1,160 | 1,160
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 1,118 | 18,647
Digestive Tract 1,117 | 18,473
Blood and immune system 1,116 | 17,995
Urinary Tract 1,116 | 18,444
Endocrine System 1,114 | 18,512
Nervous System 1,112 | 18,561
Liver and Pancreas 1,111 | 18,136
Male tissues 1,110 | 17,969
Cardiovascular System 1,103 | 17,958
Respiratory system 1,098 | 17,484
Skin and soft tissues 1,097 | 18,115

Target Family

Non-IDG 661 | 11,971
Enzyme 230 | 4,146
Transcription Factor 99 | 1,400
Kinase 57 | 634
Transporter 38 | 473
Epigenetic 29 | 242
GPCR 18 | 406
Ion Channel 10 | 341
TF/Epigenetic 10 | 38
Nuclear Receptor 4 | 48
oGPCR 4 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Interleukin-1 receptor-associated kinase 1 IRAK1 Tchem Kinase -2.51851 320.4 729
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Natural killer cell receptor 2B4 CD244 Tbio Non-IDG -2.27438 190.1 418
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567