Development Level

Tbio 69 | 11,651
Tchem 13 | 1,388
Tclin 8 | 612

Collection

Ion Channel: IDG Consortium (T... 2 | 99
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased body weight 3 | 161
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
enlarged uterus 3 | 11
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
preweaning lethality, incomple... 3 | 499
small superior vagus ganglion 3 | 74
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
abnormal lung morphology 2 | 26
abnormal seminal vesicle morph... 2 | 114
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased heart weight 2 | 27
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
enlarged kidney 2 | 14
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
hypoactivity 2 | 132
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased neutrophil cell numb... 2 | 46
small kidney 2 | 16
thrombocytopenia 2 | 56
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal pelvic girdle bone mo... 1 | 12
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
cataract 1 | 92
cystolithiasis 1 | 3
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased vertical activity 1 | 208
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
hyperactivity 1 | 148
impaired righting response 1 | 26
increased bone mineral density 1 | 72
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
long tibia 1 | 25
male infertility 1 | 123
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
prolonged ST segment 1 | 36
short tibia 1 | 97
small testis 1 | 58
stereotypic behavior 1 | 3
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

Renal Insufficiency 90 | 90
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 87 | 17,369
Female tissues 87 | 17,400
Urinary Tract 87 | 16,678
Endocrine System 86 | 18,159
Skin and soft tissues 86 | 17,230
Liver and Pancreas 85 | 16,750
Male tissues 84 | 17,142
Nervous System 84 | 16,725
Blood and immune system 82 | 16,909
Respiratory system 81 | 16,393
Cardiovascular System 74 | 15,192

Target Family

Non-IDG 43 | 12,091
Enzyme 20 | 4,145
Transcription Factor 9 | 1,400
Ion Channel 6 | 344
Transporter 5 | 473
Kinase 4 | 634
Epigenetic 1 | 242
GPCR 1 | 408
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
AMME syndrome candidate gene 1 protein AMMECR1 Tbio Non-IDG -0.63077 4.76 84
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.55553 37.1 191
Intraflagellar transport protein 27 homolog IFT27 Tbio Enzyme -1.24496 16.5 91
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.20394 172.2 226
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.58058 376.0 164
Amiloride-sensitive sodium channel subunit gamma SCNN1G Tclin Ion Channel -2.10269 131.1 212
H(+)/Cl(-) exchange transporter 5 CLCN5 Tbio Ion Channel -2.32606 225.3 156
Erythropoietin EPO Tbio Non-IDG -3.92285 8985.5 837