Development Level

Tbio 281 | 10,625
Tchem 135 | 1,890
Tclin 43 | 602
Tdark 12 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 18 | 633
preweaning lethality, incomple... 11 | 260
abnormal behavior 8 | 226
decreased lean body mass 8 | 195
decreased rib number 7 | 59
decreased bone mineral content 6 | 157
decreased heart weight 6 | 44
enlarged heart 6 | 111
increased or absent threshold ... 6 | 128
short tibia 6 | 82
abnormal lens morphology 5 | 73
abnormal spleen morphology 5 | 36
decreased body length 5 | 108
decreased grip strength 5 | 123
decreased total body fat amoun... 5 | 186
increased circulating alkaline... 5 | 119
small testis 5 | 37
abnormal embryo size 4 | 112
abnormal heart morphology 4 | 51
abnormal testis morphology 4 | 30
embryonic lethality prior to t... 4 | 187
hyperactivity 4 | 108
impaired glucose tolerance 4 | 52
increased exploration in new e... 4 | 56
abnormal bone structure 3 | 131
abnormal digit morphology 3 | 13
abnormal maxilla morphology 3 | 16
abnormal retina morphology 3 | 100
abnormal seminal vesicle morph... 3 | 47
abnormal tibia morphology 3 | 14
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 77
decreased circulating bilirubi... 3 | 14
decreased spleen weight 3 | 13
increased bone mineral content 3 | 92
increased circulating chloride... 3 | 43
increased fasted circulating g... 3 | 68
increased lean body mass 3 | 107
limb grasping 3 | 35
straub tail 3 | 26
abnormal QRS complex 2 | 25
abnormal cornea morphology 2 | 24
abnormal cranium morphology 2 | 32
abnormal epididymis morphology 2 | 31
abnormal forebrain development 2 | 18
abnormal gait 2 | 51
abnormal head morphology 2 | 10
abnormal heart left ventricle ... 2 | 20
abnormal hindbrain development 2 | 24
abnormal iris morphology 2 | 12
abnormal lung morphology 2 | 15
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal optic disc morphology 2 | 10
abnormal retinal pigmentation 2 | 61
abnormal sleep behavior 2 | 63
abnormal thoracic vertebrae mo... 2 | 16
abnormal tooth morphology 2 | 24
cataract 2 | 26
decreased body weight 2 | 174
decreased circulating alkaline... 2 | 41
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating magnesiu... 2 | 11
decreased circulating triglyce... 2 | 83
decreased fasted circulating g... 2 | 49
decreased hemoglobin content 2 | 53
decreased kidney weight 2 | 7
decreased neutrophil cell numb... 2 | 37
decreased startle reflex 2 | 48
enlarged epididymis 2 | 27
enlarged spleen 2 | 26
hypoactivity 2 | 89
increased circulating HDL chol... 2 | 63
increased circulating alanine ... 2 | 11
increased circulating potassiu... 2 | 31
increased circulating sodium l... 2 | 71
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased total body fat amoun... 2 | 57
irregularly shaped pupil 2 | 7
male infertility 2 | 62
narrow eye opening 2 | 15
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal locomotor activation 1 | 26
abnormal motor capabilities/co... 1 | 4
abnormal startle reflex 1 | 14
corneal opacity 1 | 25
decreased eosinophil cell numb... 1 | 41
decreased pulmonary respirator... 1 | 4
decreased thoracic vertebrae n... 1 | 7
female infertility 1 | 34
impaired righting response 1 | 19
increased bone mineral density 1 | 52
increased circulating choleste... 1 | 53
increased sacral vertebrae num... 1 | 62
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
small thymus 1 | 11

Disease

Prostatic Neoplasms 471 | 471
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Male tissues 469 | 17,969
Digestive Tract 468 | 18,473
Female tissues 467 | 18,647
Blood and immune system 466 | 17,995
Endocrine System 466 | 18,512
Nervous System 466 | 18,561
Urinary Tract 466 | 18,444
Liver and Pancreas 465 | 18,136
Cardiovascular System 464 | 17,958
Respiratory system 464 | 17,484
Skin and soft tissues 463 | 18,115

Target Family

Non-IDG 237 | 11,971
Enzyme 137 | 4,146
Transcription Factor 38 | 1,400
Kinase 27 | 634
Epigenetic 9 | 242
Transporter 9 | 473
Nuclear Receptor 7 | 48
GPCR 4 | 406
Ion Channel 2 | 341
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Uridine-cytidine kinase 2 UCK2 Tbio Kinase -1.39159 27.7 106
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Zinc-alpha-2-glycoprotein AZGP1 Tbio Non-IDG -2.14317 164.1 198
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Epithelial discoidin domain-containing receptor 1 DDR1 Tchem Kinase -2.21530 0.00000 460
Metallothionein-2 MT2A Tbio Non-IDG -2.42641 259.2 92
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Nucleotide exchange factor SIL1 SIL1 Tbio Non-IDG -2.97229 967.7 187