Development Level

Tbio 124 | 11,651
Tchem 25 | 1,388
Tclin 13 | 612
Tdark 13 | 6,593

Collection

Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 10 | 979
preweaning lethality, incomple... 6 | 499
abnormal bone structure 5 | 187
decreased lean body mass 4 | 135
decreased vertical activity 4 | 208
abnormal embryo size 3 | 220
enlarged heart 3 | 210
increased circulating choleste... 3 | 66
increased total body fat amoun... 3 | 134
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
abnormal cornea morphology 2 | 31
abnormal heart morphology 2 | 162
abnormal spleen morphology 2 | 55
corneal opacity 2 | 32
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased body weight 2 | 25
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased fasted circulating g... 2 | 76
abnormal eye morphology 1 | 68
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lymph node morphology 1 | 3
abnormal male genitalia morpho... 1 | 3
abnormal maxilla morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
anophthalmia 1 | 33
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating phosphat... 1 | 27
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased mature B cell number 1 | 7
decreased respiratory quotient 1 | 16
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged spleen 1 | 41
female infertility 1 | 60
fused cornea and lens 1 | 5
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased B cell number 1 | 9
increased T cell number 1 | 6
increased anxiety-related resp... 1 | 2
increased blood urea nitrogen ... 1 | 48
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased caudal vertebrae num... 1 | 7
increased circulating creatini... 1 | 38
increased circulating glycerol... 1 | 9
increased circulating serum al... 1 | 22
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
iris synechia 1 | 3
male infertility 1 | 123
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
premature death 1 | 5
prenatal lethality prior to he... 1 | 87
scaly skin 1 | 4
small adrenal glands 1 | 16
small kidney 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
small thymus 1 | 16

Disease

Prostate cancer 175 | 175
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 172 | 18,159
Digestive Tract 168 | 17,369
Male tissues 168 | 17,142
Female tissues 167 | 17,400
Urinary Tract 165 | 16,678
Skin and soft tissues 164 | 17,230
Blood and immune system 160 | 16,909
Liver and Pancreas 160 | 16,750
Respiratory system 157 | 16,393
Nervous System 156 | 16,725
Cardiovascular System 143 | 15,192

Target Family

Non-IDG 89 | 12,091
Enzyme 39 | 4,145
Transcription Factor 23 | 1,400
Kinase 9 | 634
Transporter 5 | 473
Epigenetic 4 | 242
Ion Channel 2 | 344
Nuclear Receptor 2 | 48
GPCR 1 | 408
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Annexin A13 ANXA13 Tbio Non-IDG -1.19458 15.6 162
Cysteine-rich secretory protein 3 CRISP3 Tbio Non-IDG -1.58618 43.2 129
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610
Nuclear receptor coactivator 4 NCOA4 Tbio Non-IDG -2.20245 136.0 283
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
Melanophilin MLPH Tbio Non-IDG -1.57425 39.8 142
Zinc transporter ZIP1 SLC39A1 Tbio Transporter -1.89903 75.9 61
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.52487 33.2 60