Development Level

Tbio 117 | 10,625
Tchem 33 | 1,890
Tclin 11 | 602
Tdark 11 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 8 | 633
abnormal bone structure 3 | 131
decreased lean body mass 3 | 195
increased circulating HDL chol... 3 | 63
increased exploration in new e... 3 | 56
abnormal QRS complex 2 | 25
abnormal bone mineralization 2 | 55
abnormal cornea morphology 2 | 24
abnormal embryo size 2 | 112
corneal opacity 2 | 25
decreased body weight 2 | 174
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
improved glucose tolerance 2 | 56
increased body weight 2 | 42
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
increased fasted circulating g... 2 | 68
increased total body fat amoun... 2 | 57
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal coping response 1 | 12
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal lymph node morphology 1 | 3
abnormal maxilla morphology 1 | 16
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal skin appearance 1 | 8
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
anophthalmia 1 | 20
decreased CD4-positive, alpha ... 1 | 19
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased basophil cell number 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased circulating HDL chol... 1 | 77
decreased circulating chloride... 1 | 32
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating glycerol... 1 | 19
decreased circulating phosphat... 1 | 15
decreased circulating potassiu... 1 | 17
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased erythrocyte cell num... 1 | 43
decreased hematocrit 1 | 25
decreased kidney weight 1 | 7
decreased mature B cell number 1 | 25
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased thermal nociceptive ... 1 | 4
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
eye hemorrhage 1 | 1
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
impaired pupillary reflex 1 | 14
increased B cell number 1 | 23
increased T cell number 1 | 15
increased anxiety-related resp... 1 | 1
increased basophil cell number 1 | 2
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating glycerol... 1 | 11
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
increased respiratory quotient 1 | 12
increased sacral vertebrae num... 1 | 62
microphthalmia 1 | 15
narrow eye opening 1 | 15
oligodactyly 1 | 14
small adrenal glands 1 | 15
small kidney 1 | 10
small testis 1 | 37
small thymus 1 | 11
thick ventricular wall 1 | 7

Disease

Prostate cancer 172 | 172
ovarian cancer 8,492 | 8,492
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,473 | 4,473
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,163 | 3,163
Breast cancer 3,099 | 3,099
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,714 | 2,714
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,670 | 1,670
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,563 | 1,563
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,328 | 1,328
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,171 | 1,171
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
dermatomyositis 967 | 967
Atopic dermatitis 944 | 944
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 785 | 785
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
hepatocellular carcinoma 550 | 550
Down syndrome 548 | 548
Endometriosis 535 | 535
chronic rhinosinusitis 512 | 512
Schizophrenia 503 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
gastric cancer 436 | 436
Amyotrophic Lateral Sclerosis 432 | 432
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 397 | 397
Neurodegenerative disease 383 | 383
sarcoidosis 368 | 368
Parkinson's disease 364 | 364
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 335 | 335
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Male tissues 169 | 17,969
Liver and Pancreas 168 | 18,136
Digestive Tract 167 | 18,473
Nervous System 167 | 18,561
Endocrine System 166 | 18,512
Female tissues 166 | 18,647
Urinary Tract 165 | 18,444
Cardiovascular System 164 | 17,958
Skin and soft tissues 164 | 18,115
Blood and immune system 163 | 17,995
Respiratory system 162 | 17,484

Target Family

Non-IDG 85 | 11,969
Enzyme 39 | 4,146
Transcription Factor 23 | 1,400
Kinase 9 | 634
Transporter 5 | 473
Epigenetic 4 | 242
Ion Channel 3 | 341
Nuclear Receptor 2 | 48
GPCR 1 | 408
oGPCR 1 | 421

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.10264 130.3 456
Acyl-coenzyme A oxidase-like protein ACOXL Tdark Enzyme -0.20444 1.52 22
Ankyrin-2 ANK2 Tbio Non-IDG -2.04838 107.1 205
Alpha-methylacyl-CoA racemase AMACR Tbio Enzyme -2.45535 296.1 443
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 BAIAP2L1 Tbio Non-IDG -1.08192 13.9 107
Krueppel-like factor 6 KLF6 Tbio Transcription Factor -2.33566 239.4 148
Glutamate-rich protein 4 ERICH4 Tdark Non-IDG 0.00000 4
UV excision repair protein RAD23 homolog B RAD23B Tbio Non-IDG -1.98667 88.6 284
Glycine N-methyltransferase GNMT Tbio Enzyme -1.54344 41.0 182
Metalloreductase STEAP1 STEAP1 Tbio Enzyme -1.63486 43.9 294