1. Home
  2. Targets
Target Filters...

Development Level

Tbio 104 | 11,445
Tchem 22 | 1,598
Tclin 16 | 613

Collection

Ion Channel: IDG Consortium (T... 1 | 99
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 17 | 979
decreased body weight 6 | 161
embryonic lethality prior to o... 5 | 239
abnormal behavior 4 | 298
decreased bone mineral content 4 | 151
embryonic lethality prior to t... 4 | 278
increased blood urea nitrogen ... 4 | 48
increased heart weight 4 | 62
abnormal bone structure 3 | 187
abnormal gait 3 | 69
abnormal lens morphology 3 | 81
decreased erythrocyte cell num... 3 | 62
decreased hemoglobin content 3 | 68
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
increased circulating alkaline... 3 | 122
increased circulating calcium ... 3 | 34
increased circulating sodium l... 3 | 71
increased lean body mass 3 | 172
increased startle reflex 3 | 112
abnormal embryo size 2 | 220
abnormal spine curvature 2 | 9
cataract 2 | 92
decreased body length 2 | 101
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating choleste... 2 | 93
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
improved glucose tolerance 2 | 79
increased circulating phosphat... 2 | 26
increased circulating triglyce... 2 | 42
increased neutrophil cell numb... 2 | 46
male infertility 2 | 123
persistence of hyaloid vascula... 2 | 33
preweaning lethality, incomple... 2 | 499
abnormal forelimb morphology 1 | 2
abnormal hair growth 1 | 10
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal locomotor activation 1 | 16
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
cyanosis 1 | 7
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating bilirubi... 1 | 19
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased hematocrit 1 | 46
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
impaired pupillary reflex 1 | 26
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87
small testis 1 | 58
tremors 1 | 39

Disease

Progressive disorder 142 | 142
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 142 | 18,159
Digestive Tract 141 | 17,369
Female tissues 141 | 17,400
Male tissues 141 | 17,142
Skin and soft tissues 141 | 17,230
Liver and Pancreas 140 | 16,750
Nervous System 140 | 16,725
Blood and immune system 138 | 16,909
Respiratory system 138 | 16,393
Urinary Tract 138 | 16,678
Cardiovascular System 135 | 15,192

Target Family

Non-IDG 63 | 12,091
Enzyme 51 | 4,145
Kinase 8 | 634
Transporter 8 | 473
Ion Channel 6 | 344
Transcription Factor 5 | 1,400
Nuclear Receptor 1 | 48

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Desmin DES Tbio Non-IDG -1.56068 36.6 991
Four and a half LIM domains protein 1 FHL1 Tbio Non-IDG -2.46134 291.4 312
Cytochrome c oxidase assembly protein COX15 homolog COX15 Tbio Enzyme -1.37513 23.0 104
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164
Delta-1-pyrroline-5-carboxylate synthase ALDH18A1 Tbio Enzyme -2.34260 216.5 146
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 Tclin Enzyme -2.97252 871.7 197
AFG3-like protein 2 AFG3L2 Tbio Enzyme -1.58716 39.9 164
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
Vacuolar protein sorting-associated protein 13A VPS13A Tbio Non-IDG -2.19966 172.3 22
Polyadenylate-binding protein 2 PABPN1 Tbio Non-IDG -2.48757 316.4 120