Development Level

Tbio 84 | 11,445
Tdark 12 | 6,588
Tchem 10 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 16 | 979
decreased body weight 4 | 161
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 4 | 499
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
increased circulating alkaline... 3 | 122
increased total body fat amoun... 3 | 134
abnormal craniofacial morpholo... 2 | 33
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal neural tube closure 2 | 46
decreased circulating glucose ... 2 | 126
decreased grip strength 2 | 116
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased respiratory quotient 2 | 16
embryonic growth retardation 2 | 106
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased body weight 2 | 25
increased fasted circulating g... 2 | 76
long tibia 2 | 25
male infertility 2 | 123
small superior vagus ganglion 2 | 74
abnormal QT variability 1 | 10
abnormal behavioral response t... 1 | 66
abnormal embryo turning 1 | 31
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal forebrain morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain development 1 | 16
abnormal hindbrain morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal midbrain morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 12
abnormal placenta size 1 | 20
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal retinal vasculature m... 1 | 27
abnormal startle reflex 1 | 15
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
cleft palate 1 | 8
cyanosis 1 | 7
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac stroke volum... 1 | 6
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating free fat... 1 | 31
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged urinary bladder 1 | 8
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
limb grasping 1 | 41
microphthalmia 1 | 26
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
prolonged PR interval 1 | 15
prolonged QRS complex duration 1 | 8
prolonged QT interval 1 | 38
short tibia 1 | 97
shortened QT interval 1 | 4
small testis 1 | 58

Disease

Polydactyly 107 | 107
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Digestive Tract 106 | 17,369
Female tissues 106 | 17,400
Endocrine System 105 | 18,159
Male tissues 105 | 17,142
Skin and soft tissues 105 | 17,230
Urinary Tract 104 | 16,678
Liver and Pancreas 101 | 16,750
Nervous System 100 | 16,725
Respiratory system 98 | 16,393
Blood and immune system 96 | 16,909
Cardiovascular System 96 | 15,192

Target Family

Non-IDG 75 | 12,091
Transcription Factor 17 | 1,400
Enzyme 8 | 4,145
Epigenetic 3 | 242
Kinase 3 | 634
Ion Channel 1 | 344

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
B9 domain-containing protein 1 B9D1 Tdark Non-IDG -0.61316 3.72 43
Bardet-Biedl syndrome 2 protein BBS2 Tbio Non-IDG -2.84516 693.9 69
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Protein C8orf37 C8orf37 Tbio Non-IDG -2.10097 123.4 32
Sodium channel and clathrin linker 1 SCLT1 Tdark Non-IDG -0.50820 2.61 97
Intraflagellar transport protein 52 homolog IFT52 Tbio Non-IDG -1.09507 12.7 13
Limb region 1 protein homolog LMBR1 Tbio Non-IDG -2.39449 251.0 126
Zinc finger SWIM domain-containing protein 6 ZSWIM6 Tbio Non-IDG -1.22042 16.2 67
WD repeat-containing protein 60 WDR60 Tbio Non-IDG -0.64761 3.98 23
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200