Development Level

Tbio 259 | 11,651
Tchem 46 | 1,388
Tdark 29 | 6,593
Tclin 26 | 612

Collection

RFA-RM-18-021 3 | 328
Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 27 | 979
preweaning lethality, incomple... 12 | 499
abnormal behavior 7 | 298
decreased body weight 7 | 161
decreased vertical activity 7 | 208
increased circulating HDL chol... 7 | 80
increased heart weight 7 | 62
abnormal bone structure 6 | 187
decreased total body fat amoun... 6 | 207
embryonic lethality prior to t... 6 | 278
increased bone mineral content 6 | 108
increased circulating choleste... 6 | 66
increased lean body mass 6 | 172
increased startle reflex 6 | 112
decreased circulating LDL chol... 5 | 38
embryonic lethality prior to o... 5 | 239
enlarged heart 5 | 210
improved glucose tolerance 5 | 79
abnormal retina morphology 4 | 71
decreased bone mineral content 4 | 151
decreased circulating triglyce... 4 | 79
decreased lactate dehydrogenas... 4 | 16
hypoactivity 4 | 132
increased bone mineral density 4 | 72
increased circulating alkaline... 4 | 122
increased total body fat amoun... 4 | 134
short tibia 4 | 97
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
abnormal lens morphology 3 | 81
abnormal lung morphology 3 | 26
cataract 3 | 92
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating alanine ... 3 | 47
decreased circulating aspartat... 3 | 34
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased lean body mass 3 | 135
hyperactivity 3 | 148
increased circulating creatini... 3 | 38
increased hematocrit 3 | 46
abnormal brain morphology 2 | 13
abnormal glucose homeostasis 2 | 4
abnormal male genitalia morpho... 2 | 3
decreased IgG1 level 2 | 8
decreased blood urea nitrogen ... 2 | 51
decreased circulating alkaline... 2 | 46
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased circulating phosphat... 2 | 27
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
increased blood urea nitrogen ... 2 | 48
increased circulating chloride... 2 | 41
increased circulating free fat... 2 | 20
increased circulating serum al... 2 | 22
increased circulating sodium l... 2 | 71
increased fasted circulating g... 2 | 76
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased red blood cell distr... 2 | 34
male infertility 2 | 123
small testis 2 | 58
thrombocytopenia 2 | 56
thrombocytosis 2 | 27
vertebral transformation 2 | 12
abnormal behavioral response t... 1 | 66
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal liver morphology 1 | 17
abnormal neural tube morpholog... 1 | 12
abnormal vocalization 1 | 21
decreased IgE level 1 | 6
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased grip strength 1 | 116
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating bilirubi... 1 | 16
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
small thymus 1 | 16
tremors 1 | 39
urinary bladder obstruction 1 | 4

Disease

Polycystic ovary syndrome 360 | 360
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 352 | 18,159
Female tissues 347 | 17,400
Skin and soft tissues 347 | 17,230
Digestive Tract 345 | 17,369
Blood and immune system 339 | 16,909
Nervous System 339 | 16,725
Liver and Pancreas 337 | 16,750
Male tissues 336 | 17,142
Respiratory system 333 | 16,393
Urinary Tract 333 | 16,678
Cardiovascular System 314 | 15,192

Target Family

Non-IDG 208 | 12,091
Enzyme 80 | 4,145
Transcription Factor 32 | 1,400
Kinase 18 | 634
GPCR 7 | 408
Transporter 6 | 473
Nuclear Receptor 4 | 48
Ion Channel 3 | 344
Epigenetic 2 | 242

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Uncharacterized protein ZSWIM9 ZSWIM9 Tdark Non-IDG 0.00000 12
GDH/6PGL endoplasmic bifunctional protein H6PD Tbio Non-IDG -2.24806 169.7 207
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Nicotinamide phosphoribosyltransferase NAMPT Tchem Enzyme -2.94790 1054.3 667
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Angiopoietin-like protein 8 ANGPTL8 Tbio Non-IDG -2.07410 141.2 93
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Enoyl-CoA delta isomerase 1, mitochondrial ECI1 Tbio Enzyme -2.67168 459.1 229
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075