Development Level

Tbio 1,248 | 10,625
Tdark 379 | 7,003
Tchem 204 | 1,890
Tclin 62 | 602

Collection

Eligible Ion Channel Proteins 18 | 117
Eligible Kinase Proteins 17 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 68 | 633
preweaning lethality, incomple... 46 | 260
abnormal behavior 42 | 226
decreased total body fat amoun... 42 | 186
decreased lean body mass 36 | 195
embryonic lethality prior to t... 30 | 187
decreased body weight 28 | 174
decreased bone mineral content 28 | 157
increased lean body mass 26 | 107
abnormal bone structure 25 | 131
hyperactivity 23 | 108
increased bone mineral content 21 | 92
abnormal retina morphology 20 | 100
decreased body length 20 | 108
decreased bone mineral density 19 | 126
embryonic lethality prior to o... 19 | 148
increased or absent threshold ... 19 | 128
increased circulating alkaline... 18 | 119
decreased grip strength 17 | 123
hypoactivity 17 | 89
decreased circulating glucose ... 16 | 121
increased mean corpuscular hem... 16 | 93
abnormal embryo size 14 | 112
decreased circulating HDL chol... 14 | 77
decreased circulating triglyce... 14 | 83
increased blood urea nitrogen ... 14 | 44
increased mean corpuscular vol... 14 | 91
decreased circulating serum al... 13 | 79
decreased hemoglobin content 13 | 53
decreased prepulse inhibition 13 | 52
increased sacral vertebrae num... 13 | 62
abnormal lens morphology 12 | 73
decreased circulating insulin ... 12 | 75
increased total body fat amoun... 12 | 57
abnormal sleep behavior 11 | 63
decreased leukocyte cell numbe... 11 | 54
decreased lumbar vertebrae num... 11 | 62
increased grip strength 11 | 83
short tibia 11 | 82
decreased circulating choleste... 10 | 85
increased hemoglobin content 10 | 45
tremors 10 | 34
abnormal bone mineralization 9 | 55
abnormal retinal pigmentation 9 | 61
decreased circulating total pr... 9 | 41
decreased startle reflex 9 | 48
enlarged heart 9 | 111
increased fasted circulating g... 9 | 68
increased startle reflex 9 | 38
abnormal gait 8 | 51
decreased circulating alanine ... 8 | 53
decreased erythrocyte cell num... 8 | 43
decreased fasted circulating g... 8 | 49
impaired glucose tolerance 8 | 52
increased circulating HDL chol... 8 | 63
increased circulating calcium ... 8 | 32
abnormal coat/hair pigmentatio... 7 | 54
abnormal locomotor activation 7 | 26
decreased caudal vertebrae num... 7 | 49
decreased circulating alkaline... 7 | 41
decreased circulating fructosa... 7 | 31
decreased eosinophil cell numb... 7 | 41
increased body weight 7 | 42
increased circulating triglyce... 7 | 24
limb grasping 7 | 35
abnormal cranium morphology 6 | 32
abnormal testis morphology 6 | 30
corneal opacity 6 | 25
decreased circulating LDL chol... 6 | 37
decreased hematocrit 6 | 25
decreased mean corpuscular hem... 6 | 34
decreased mean corpuscular vol... 6 | 50
increased circulating chloride... 6 | 43
increased circulating choleste... 6 | 53
prenatal lethality prior to he... 6 | 64
thrombocytopenia 6 | 46
abnormal QRS complex 5 | 25
abnormal cornea morphology 5 | 24
abnormal femur morphology 5 | 14
abnormal iris morphology 5 | 12
abnormal neural tube closure 5 | 37
abnormal retinal blood vessel ... 5 | 18
abnormal rib morphology 5 | 28
abnormal tooth morphology 5 | 24
absent startle reflex 5 | 15
cataract 5 | 26
decreased circulating calcium ... 5 | 33
decreased circulating free fat... 5 | 39
decreased neutrophil cell numb... 5 | 37
decreased rib number 5 | 59
improved glucose tolerance 5 | 56
increased circulating glycerol... 5 | 11
increased circulating iron lev... 5 | 25
increased heart weight 5 | 37
increased hematocrit 5 | 36
increased mean corpuscular hem... 5 | 25
increased rib number 5 | 41
persistence of hyaloid vascula... 5 | 22
small testis 5 | 37
vertebral fusion 5 | 23

Disease

Pick disease 1,893 | 1,893
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Digestive Tract 1,885 | 18,473
Nervous System 1,884 | 18,561
Female tissues 1,883 | 18,647
Liver and Pancreas 1,883 | 18,136
Urinary Tract 1,881 | 18,444
Endocrine System 1,880 | 18,512
Cardiovascular System 1,879 | 17,958
Male tissues 1,879 | 17,969
Blood and immune system 1,876 | 17,995
Respiratory system 1,870 | 17,484
Skin and soft tissues 1,869 | 18,115

Target Family

Non-IDG 1,090 | 11,971
Enzyme 440 | 4,146
Transcription Factor 112 | 1,400
Kinase 91 | 634
Transporter 58 | 473
Ion Channel 47 | 341
Epigenetic 25 | 242
GPCR 19 | 406
Nuclear Receptor 6 | 48
TF/Epigenetic 5 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
VPS10 domain-containing receptor SorCS3 SORCS3 Tbio Non-IDG -0.54622 5.51 46
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Microtubule-associated protein RP/EB family member 3 MAPRE3 Tbio Non-IDG -2.14681 132.5 161
Transmembrane gamma-carboxyglutamic acid protein 3 PRRG3 Tdark Non-IDG -0.21639 1.71 76