Development Level

Tbio 177 | 10,625
Tchem 82 | 1,890
Tclin 26 | 602
Tdark 18 | 7,003

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

abnormal behavior 10 | 226
preweaning lethality, incomple... 8 | 260
preweaning lethality, complete... 6 | 633
increased circulating alkaline... 5 | 119
increased circulating potassiu... 5 | 31
abnormal gait 4 | 51
abnormal retina morphology 4 | 100
decreased body weight 4 | 174
decreased grip strength 4 | 123
embryonic lethality prior to t... 4 | 187
enlarged heart 4 | 111
hyperactivity 4 | 108
abnormal epididymis morphology 3 | 31
abnormal lens morphology 3 | 73
abnormal retinal pigmentation 3 | 61
decreased bone mineral content 3 | 157
decreased bone mineral density 3 | 126
decreased circulating alanine ... 3 | 53
decreased heart weight 3 | 44
hypoactivity 3 | 89
increased circulating alanine ... 3 | 11
increased circulating aspartat... 3 | 17
increased circulating choleste... 3 | 53
increased mean corpuscular hem... 3 | 93
abnormal embryo size 2 | 112
abnormal heart morphology 2 | 51
cataract 2 | 26
decreased circulating chloride... 2 | 32
decreased mean corpuscular hem... 2 | 34
decreased spleen weight 2 | 13
enlarged epididymis 2 | 27
increased blood urea nitrogen ... 2 | 44
increased grip strength 2 | 83
increased mean corpuscular vol... 2 | 91
long tibia 2 | 13
prenatal lethality prior to he... 2 | 64
straub tail 2 | 26
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal lung morphology 1 | 15
abnormal retinal inner nuclear... 1 | 5
abnormal skin coloration 1 | 18
abnormal skin morphology 1 | 23
abnormal sleep behavior 1 | 63
abnormal testis morphology 1 | 30
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased NK cell number 1 | 16
decreased body length 1 | 108
decreased cardiac muscle contr... 1 | 5
decreased caudal vertebrae num... 1 | 49
decreased circulating creatini... 1 | 31
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased heart rate 1 | 10
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased monocyte cell number 1 | 28
decreased neutrophil cell numb... 1 | 37
decreased rib number 1 | 59
decreased total retina thickne... 1 | 20
embryonic lethality prior to o... 1 | 148
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
impaired glucose tolerance 1 | 52
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased eosinophil cell numb... 1 | 9
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
lethargy 1 | 5
limb grasping 1 | 35
small adrenal glands 1 | 15
small seminal vesicle 1 | 6
small testis 1 | 37
tremors 1 | 34

Disease

Peripheral Neuropathy 303 | 303
ovarian cancer 8,484 | 8,484
osteosarcoma 7,933 | 7,933
psoriasis 6,685 | 6,685
medulloblastoma, large-cell 6,234 | 6,234
glioblastoma 5,572 | 5,572
lung cancer 4,466 | 4,466
atypical teratoid / rhabdoid tumor 4,369 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,289 | 3,289
malignant mesothelioma 3,162 | 3,162
Breast cancer 3,094 | 3,094
pilocytic astrocytoma 3,086 | 3,086
primitive neuroectodermal tumor 3,031 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,988 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,956 | 2,956
invasive ductal carcinoma 2,950 | 2,950
oligodendroglioma 2,849 | 2,849
lung carcinoma 2,844 | 2,844
non-small cell lung cancer 2,798 | 2,798
lung adenocarcinoma 2,713 | 2,713
pediatric high grade glioma 2,712 | 2,712
ependymoma 2,514 | 2,514
Cancer 2,346 | 2,346
pancreatic cancer 2,300 | 2,300
interstitial cystitis 2,299 | 2,299
subependymal giant cell astrocytoma 2,287 | 2,287
group 3 medulloblastoma 2,254 | 2,254
astrocytic glioma 2,241 | 2,241
adult high grade glioma 2,148 | 2,148
Carcinoma 2,147 | 2,147
ulcerative colitis 2,087 | 2,087
pituitary cancer 1,972 | 1,972
Pick disease 1,893 | 1,893
group 4 medulloblastoma 1,875 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,795 | 1,795
ductal carcinoma in situ 1,745 | 1,745
cystic fibrosis 1,665 | 1,665
diabetes mellitus 1,663 | 1,663
breast carcinoma 1,614 | 1,614
tuberculosis 1,557 | 1,557
posterior fossa group B ependymoma 1,530 | 1,530
medulloblastoma 1,524 | 1,524
posterior fossa group A ependymoma 1,511 | 1,511
astrocytoma 1,493 | 1,493
sonic hedgehog group medulloblastoma 1,482 | 1,482
colon cancer 1,475 | 1,475
adrenocortical carcinoma 1,427 | 1,427
Multiple myeloma 1,327 | 1,327
primary pancreatic ductal adenocarcinoma 1,271 | 1,271
juvenile dermatomyositis 1,189 | 1,189
Rheumatoid Arthritis 1,160 | 1,160
acute quadriplegic myopathy 1,157 | 1,157
atypical teratoid/rhabdoid tumor 1,095 | 1,095
spina bifida 1,064 | 1,064
cutaneous lupus erythematosus 1,056 | 1,056
nasopharyngeal carcinoma 1,056 | 1,056
Atopic dermatitis 944 | 944
dermatomyositis 933 | 933
active Crohn's disease 918 | 918
non primary Sjogren syndrome sicca 840 | 840
gastric carcinoma 832 | 832
primary Sjogren syndrome 789 | 789
acute myeloid leukemia 780 | 780
Waldenstrons macroglobulinemia 765 | 765
esophageal adenocarcinoma 737 | 737
tuberculosis and treatment for 6 months 686 | 686
progressive supranuclear palsy 674 | 674
aldosterone-producing adenoma 664 | 664
Alzheimer's disease 644 | 644
Obesity 616 | 616
Duchenne muscular dystrophy 602 | 602
Intellectual disability 573 | 573
pancreatic carcinoma 567 | 567
fibroadenoma 557 | 557
Down syndrome 548 | 548
Endometriosis 535 | 535
hepatocellular carcinoma 532 | 532
chronic rhinosinusitis 512 | 512
Schizophrenia 501 | 501
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 499
Multiple Sclerosis 498 | 498
mucosa-associated lymphoid tissue lymphoma 480 | 480
active ulcerative colitis 477 | 477
Prostatic Neoplasms 471 | 471
IGA Glomerulonephritis 454 | 454
Amyotrophic Lateral Sclerosis 431 | 431
gastric cancer 430 | 430
non-small cell lung carcinoma 413 | 413
Mammary Neoplasms 410 | 410
inflammatory breast cancer 404 | 404
Kidney disease 396 | 396
Neurodegenerative disease 383 | 383
Parkinson's disease 364 | 364
sarcoidosis 358 | 358
Asthma 349 | 349
glioblastoma multiforme 347 | 347
Epilepsy 346 | 346
Polycystic Ovary Syndrome 332 | 332
nephrosclerosis 329 | 329
tuberculosis and treatment for 3 months 327 | 327
Autistic Disorder 320 | 320

Tissue

Female tissues 299 | 18,647
Endocrine System 295 | 18,512
Digestive Tract 294 | 18,473
Nervous System 294 | 18,561
Male tissues 293 | 17,969
Blood and immune system 291 | 17,995
Liver and Pancreas 291 | 18,136
Skin and soft tissues 289 | 18,115
Urinary Tract 288 | 18,444
Cardiovascular System 285 | 17,958
Respiratory system 284 | 17,484

Target Family

Non-IDG 158 | 11,971
Enzyme 76 | 4,146
Kinase 25 | 634
Transcription Factor 17 | 1,400
Transporter 16 | 473
Epigenetic 3 | 242
Nuclear Receptor 3 | 48
GPCR 2 | 406
Ion Channel 2 | 341
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Tyrosine-protein phosphatase non-receptor type 13 PTPN13 Tchem Enzyme -2.20613 177.9 120
Neurofilament heavy polypeptide NEFH Tbio Non-IDG -2.73883 563.3 681
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Ileal sodium/bile acid cotransporter SLC10A2 Tchem Transporter -2.60727 417.5 121
Lymphotoxin-alpha LTA Tbio Non-IDG -2.84770 612.8 461
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Dual specificity protein phosphatase 23 DUSP23 Tbio Enzyme -0.95604 11.5 79
Mitochondrial brown fat uncoupling protein 1 UCP1 Tbio Non-IDG -3.04555 1148.0 252
Prostaglandin G/H synthase 1 PTGS1 Tclin Enzyme -3.20847 1594.9 391