Development Level

Tbio 240 | 11,651
Tclin 64 | 612
Tchem 62 | 1,388
Tdark 26 | 6,593

Collection

RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Complete... 1 | 25
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 28 | 979
preweaning lethality, incomple... 21 | 499
abnormal behavior 13 | 298
embryonic lethality prior to t... 10 | 278
decreased bone mineral content 9 | 151
hyperactivity 9 | 148
abnormal bone structure 8 | 187
decreased lean body mass 8 | 135
decreased total body fat amoun... 8 | 207
increased total body fat amoun... 8 | 134
hypoactivity 7 | 132
increased circulating alkaline... 7 | 122
decreased body weight 6 | 161
embryonic lethality prior to o... 6 | 239
decreased blood urea nitrogen ... 5 | 51
decreased vertical activity 5 | 208
improved glucose tolerance 5 | 79
increased circulating choleste... 5 | 66
increased lean body mass 5 | 172
male infertility 5 | 123
short tibia 5 | 97
abnormal behavioral response t... 4 | 66
abnormal retina morphology 4 | 71
cardiovascular system phenotyp... 4 | 36
decreased circulating alkaline... 4 | 46
decreased circulating calcium ... 4 | 36
decreased circulating serum al... 4 | 82
decreased circulating triglyce... 4 | 79
decreased erythrocyte cell num... 4 | 62
decreased heart weight 4 | 27
decreased prepulse inhibition 4 | 82
edema 4 | 59
increased blood urea nitrogen ... 4 | 48
increased bone mineral density 4 | 72
increased circulating HDL chol... 4 | 80
increased circulating sodium l... 4 | 71
increased fasted circulating g... 4 | 76
increased startle reflex 4 | 112
abnormal lens morphology 3 | 81
abnormal locomotor behavior 3 | 24
abnormal skin morphology 3 | 50
abnormal tooth morphology 3 | 24
cataract 3 | 92
decreased basophil cell number 3 | 16
decreased caudal vertebrae num... 3 | 53
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased grip strength 3 | 116
decreased hemoglobin content 3 | 68
decreased neutrophil cell numb... 3 | 42
decreased startle reflex 3 | 75
embryonic growth retardation 3 | 106
increased bone mineral content 3 | 108
increased circulating chloride... 3 | 41
increased circulating triglyce... 3 | 42
increased erythrocyte cell num... 3 | 39
increased mean corpuscular hem... 3 | 96
increased mean platelet volume 3 | 45
increased or absent threshold ... 3 | 101
increased red blood cell distr... 3 | 34
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal embryo size 2 | 220
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal optic disc morphology 2 | 10
abnormal pericardium morpholog... 2 | 26
abnormal rib morphology 2 | 10
abnormal seminal vesicle morph... 2 | 114
abnormal sleep behavior 2 | 70
abnormal vertebrae morphology 2 | 18
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating bilirubi... 2 | 19
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased circulating sodium l... 2 | 22
decreased circulating total pr... 2 | 49
decreased eosinophil cell numb... 2 | 24
decreased exploration in new e... 2 | 11
decreased lymphocyte cell numb... 2 | 83
decreased mean platelet volume 2 | 25
increased circulating aspartat... 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating creatini... 2 | 38
increased circulating iron lev... 2 | 30
increased heart rate 2 | 23
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 36
increased spleen weight 2 | 10
increased vertical activity 2 | 24
limb grasping 2 | 41
persistence of hyaloid vascula... 2 | 33
polycystic kidney 2 | 15
small testis 2 | 58
thrombocytopenia 2 | 56
thrombocytosis 2 | 27

Disease

Parkinson's disease 392 | 392
Carcinoma 11,493 | 11,493
ovarian cancer 8,520 | 8,520
osteosarcoma 7,950 | 7,950
psoriasis 6,694 | 6,694
medulloblastoma, large-cell 6,241 | 6,241
glioblastoma 5,792 | 5,792
atypical teratoid / rhabdoid tumor 5,112 | 5,112
lung cancer 4,740 | 4,740
ependymoma 4,679 | 4,679
group 3 medulloblastoma 4,104 | 4,104
adult high grade glioma 3,801 | 3,801
Breast cancer 3,578 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,291 | 3,291
malignant mesothelioma 3,232 | 3,232
Astrocytoma, Pilocytic 3,081 | 3,081
primitive neuroectodermal tumor 3,035 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,989 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,955 | 2,955
invasive ductal carcinoma 2,951 | 2,951
non-small cell lung cancer 2,890 | 2,890
oligodendroglioma 2,850 | 2,850
lung carcinoma 2,843 | 2,843
lung adenocarcinoma 2,716 | 2,716
Kidney cancer 2,613 | 2,613
astrocytic glioma 2,597 | 2,597
Cancer 2,499 | 2,499
pancreatic cancer 2,398 | 2,398
interstitial cystitis 2,312 | 2,312
subependymal giant cell astrocytoma 2,287 | 2,287
tuberculosis 2,010 | 2,010
pituitary cancer 1,972 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,962 | 1,962
Pick disease 1,894 | 1,894
group 4 medulloblastoma 1,855 | 1,855
ulcerative colitis 1,819 | 1,819
ductal carcinoma in situ 1,745 | 1,745
diabetes mellitus 1,728 | 1,728
cystic fibrosis 1,696 | 1,696
breast carcinoma 1,638 | 1,638
colon cancer 1,478 | 1,478
Autosomal recessive predisposition 1,442 | 1,442
adrenocortical carcinoma 1,428 | 1,428
Multiple myeloma 1,332 | 1,332
Rheumatoid arthritis 1,191 | 1,191
juvenile dermatomyositis 1,187 | 1,187
Schizophrenia 1,160 | 1,160
acute quadriplegic myopathy 1,158 | 1,158
astrocytoma 1,146 | 1,146
primary pancreatic ductal adenocarcinoma 1,109 | 1,109
spina bifida 1,074 | 1,074
pediatric high grade glioma 1,064 | 1,064
nasopharyngeal carcinoma 1,058 | 1,058
cutaneous lupus erythematosus 1,057 | 1,057
Intellectual disability 1,016 | 1,016
dermatomyositis 966 | 966
Atopic dermatitis 952 | 952
active Crohn's disease 922 | 922
non primary Sjogren syndrome sicca 891 | 891
gastric carcinoma 807 | 807
Epilepsy 792 | 792
acute myeloid leukemia 783 | 783
Liver Cirrhosis, Experimental 769 | 769
Waldenstrons macroglobulinemia 765 | 765
active ulcerative colitis 764 | 764
esophageal adenocarcinoma 737 | 737
primary Sjogren syndrome 735 | 735
medulloblastoma 720 | 720
Melanoma 711 | 711
Obesity 678 | 678
progressive supranuclear palsy 676 | 676
Bipolar Disorder 666 | 666
aldosterone-producing adenoma 665 | 665
Alzheimer's disease 658 | 658
Dull intelligence 645 | 645
Low intelligence 645 | 645
Mental Retardation 645 | 645
Mental deficiency 645 | 645
Poor school performance 645 | 645
Cognitive delay 608 | 608
Global developmental delay 608 | 608
Mental and motor retardation 608 | 608
Liver cancer 604 | 604
Duchenne muscular dystrophy 601 | 601
Seizures 596 | 596
Muscle hypotonia 571 | 571
pancreatic carcinoma 562 | 562
fibroadenoma 559 | 559
hepatocellular carcinoma 547 | 547
Endometriosis 540 | 540
Multiple Sclerosis 540 | 540
Short stature 531 | 531
chronic rhinosinusitis 512 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 510 | 510
Down syndrome 499 | 499
Prostatic Neoplasms 495 | 495
mucosa-associated lymphoid tissue lymphoma 484 | 484
Skin cancer 469 | 469
posterior fossa group A ependymoma 468 | 468
sonic hedgehog group medulloblastoma 467 | 467
gastric cancer 459 | 459

Tissue

Endocrine System 385 | 18,159
Female tissues 373 | 17,400
Nervous System 372 | 16,725
Digestive Tract 370 | 17,369
Skin and soft tissues 368 | 17,230
Male tissues 365 | 17,142
Liver and Pancreas 362 | 16,750
Blood and immune system 360 | 16,909
Urinary Tract 357 | 16,678
Respiratory system 353 | 16,393
Cardiovascular System 327 | 15,192

Target Family

Non-IDG 165 | 12,091
Enzyme 98 | 4,145
Kinase 29 | 634
GPCR 28 | 408
Transcription Factor 28 | 1,400
Ion Channel 19 | 344
Transporter 19 | 473
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Oxidation resistance protein 1 OXR1 Tbio Non-IDG -1.67505 49.4 144
A disintegrin and metalloproteinase with thrombospondin motifs 2 ADAMTS2 Tbio Enzyme -2.51717 1472.5 133
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
STE20/SPS1-related proline-alanine-rich protein kinase STK39 Tbio Kinase -2.11714 148.9 575
Disks large homolog 2 DLG2 Tbio Non-IDG -1.75838 53.6 227
Sodium channel protein type 2 subunit alpha SCN2A Tclin Ion Channel -3.11580 1268.8 107
Metabotropic glutamate receptor 2 GRM2 Tchem GPCR -2.77035 612.3 315
Enoyl-CoA delta isomerase 1, mitochondrial ECI1 Tbio Enzyme -2.67168 459.1 229
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075